On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that c...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Andrea Adamo [verfasserIn] Rachel L Beingessner Mohsen Behnam Jie Chen Timothy F Jamison Klavs F Jensen Jean-Christophe M Monbaliu Allan S Myerson Eve M Revalor David R Snead Torsten Stelzer Nopphon Weeranoppanant Shin Yee Wong Ping Zhang

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Rechteinformationen:	Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science.

Schlagwörter:	Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 352(2016), 6281, Seite 61-67
Übergeordnetes Werk:	volume:352 ; year:2016 ; number:6281 ; pages:61-67

Links:	Volltext Link aufrufen Link aufrufen

DOI / URN:	10.1126/science.aaf1337

Katalog-ID:	OLC1975102010

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spelling	10.1126/science.aaf1337 doi PQ20160610 (DE-627)OLC1975102010 (DE-599)GBVOLC1975102010 (PRQ)c1440-730de568209890786d8c3bbe5a4fcb059a7857bb8b6ddcabf52681aa4c9f911c0 (KEY)0063888920160000352628100061ondemandcontinuousflowproductionofpharmaceuticalsi DE-627 ger DE-627 rakwb eng 500 DNB LING fid Andrea Adamo verfasserin aut On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis Rachel L Beingessner oth Mohsen Behnam oth Jie Chen oth Timothy F Jamison oth Klavs F Jensen oth Jean-Christophe M Monbaliu oth Allan S Myerson oth Eve M Revalor oth David R Snead oth Torsten Stelzer oth Nopphon Weeranoppanant oth Shin Yee Wong oth Ping Zhang oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6281, Seite 61-67 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6281 pages:61-67 http://dx.doi.org/10.1126/science.aaf1337 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27034366 http://search.proquest.com/docview/1778096101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6281 61-67
allfields_unstemmed	10.1126/science.aaf1337 doi PQ20160610 (DE-627)OLC1975102010 (DE-599)GBVOLC1975102010 (PRQ)c1440-730de568209890786d8c3bbe5a4fcb059a7857bb8b6ddcabf52681aa4c9f911c0 (KEY)0063888920160000352628100061ondemandcontinuousflowproductionofpharmaceuticalsi DE-627 ger DE-627 rakwb eng 500 DNB LING fid Andrea Adamo verfasserin aut On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis Rachel L Beingessner oth Mohsen Behnam oth Jie Chen oth Timothy F Jamison oth Klavs F Jensen oth Jean-Christophe M Monbaliu oth Allan S Myerson oth Eve M Revalor oth David R Snead oth Torsten Stelzer oth Nopphon Weeranoppanant oth Shin Yee Wong oth Ping Zhang oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6281, Seite 61-67 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6281 pages:61-67 http://dx.doi.org/10.1126/science.aaf1337 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27034366 http://search.proquest.com/docview/1778096101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6281 61-67
allfieldsGer	10.1126/science.aaf1337 doi PQ20160610 (DE-627)OLC1975102010 (DE-599)GBVOLC1975102010 (PRQ)c1440-730de568209890786d8c3bbe5a4fcb059a7857bb8b6ddcabf52681aa4c9f911c0 (KEY)0063888920160000352628100061ondemandcontinuousflowproductionofpharmaceuticalsi DE-627 ger DE-627 rakwb eng 500 DNB LING fid Andrea Adamo verfasserin aut On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis Rachel L Beingessner oth Mohsen Behnam oth Jie Chen oth Timothy F Jamison oth Klavs F Jensen oth Jean-Christophe M Monbaliu oth Allan S Myerson oth Eve M Revalor oth David R Snead oth Torsten Stelzer oth Nopphon Weeranoppanant oth Shin Yee Wong oth Ping Zhang oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6281, Seite 61-67 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6281 pages:61-67 http://dx.doi.org/10.1126/science.aaf1337 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27034366 http://search.proquest.com/docview/1778096101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6281 61-67
allfieldsSound	10.1126/science.aaf1337 doi PQ20160610 (DE-627)OLC1975102010 (DE-599)GBVOLC1975102010 (PRQ)c1440-730de568209890786d8c3bbe5a4fcb059a7857bb8b6ddcabf52681aa4c9f911c0 (KEY)0063888920160000352628100061ondemandcontinuousflowproductionofpharmaceuticalsi DE-627 ger DE-627 rakwb eng 500 DNB LING fid Andrea Adamo verfasserin aut On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis Rachel L Beingessner oth Mohsen Behnam oth Jie Chen oth Timothy F Jamison oth Klavs F Jensen oth Jean-Christophe M Monbaliu oth Allan S Myerson oth Eve M Revalor oth David R Snead oth Torsten Stelzer oth Nopphon Weeranoppanant oth Shin Yee Wong oth Ping Zhang oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6281, Seite 61-67 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6281 pages:61-67 http://dx.doi.org/10.1126/science.aaf1337 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27034366 http://search.proquest.com/docview/1778096101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6281 61-67
language	English
source	Enthalten in Science 352(2016), 6281, Seite 61-67 volume:352 year:2016 number:6281 pages:61-67
sourceStr	Enthalten in Science 352(2016), 6281, Seite 61-67 volume:352 year:2016 number:6281 pages:61-67
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis
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container_title	Science
authorswithroles_txt_mv	Andrea Adamo @@aut@@ Rachel L Beingessner @@oth@@ Mohsen Behnam @@oth@@ Jie Chen @@oth@@ Timothy F Jamison @@oth@@ Klavs F Jensen @@oth@@ Jean-Christophe M Monbaliu @@oth@@ Allan S Myerson @@oth@@ Eve M Revalor @@oth@@ David R Snead @@oth@@ Torsten Stelzer @@oth@@ Nopphon Weeranoppanant @@oth@@ Shin Yee Wong @@oth@@ Ping Zhang @@oth@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1975102010
language_de	englisch
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author	Andrea Adamo
spellingShingle	Andrea Adamo ddc 500 fid LING misc Pharmaceuticals misc Pharmacology misc Pharmaceutical industry misc Pharmaceutical Preparations - standards misc Diphenhydramine - chemical synthesis misc Diazepam - standards misc Pharmaceutical Preparations - chemical synthesis misc Diphenhydramine - standards misc Lidocaine - standards misc Chemistry, Pharmaceutical - methods misc Diazepam - chemical synthesis misc Lidocaine - chemical synthesis On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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topic_title	500 DNB LING fid On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system Pharmaceuticals Pharmacology Pharmaceutical industry Pharmaceutical Preparations - standards Diphenhydramine - chemical synthesis Diazepam - standards Pharmaceutical Preparations - chemical synthesis Diphenhydramine - standards Lidocaine - standards Chemistry, Pharmaceutical - methods Diazepam - chemical synthesis Lidocaine - chemical synthesis
topic	ddc 500 fid LING misc Pharmaceuticals misc Pharmacology misc Pharmaceutical industry misc Pharmaceutical Preparations - standards misc Diphenhydramine - chemical synthesis misc Diazepam - standards misc Pharmaceutical Preparations - chemical synthesis misc Diphenhydramine - standards misc Lidocaine - standards misc Chemistry, Pharmaceutical - methods misc Diazepam - chemical synthesis misc Lidocaine - chemical synthesis
topic_unstemmed	ddc 500 fid LING misc Pharmaceuticals misc Pharmacology misc Pharmaceutical industry misc Pharmaceutical Preparations - standards misc Diphenhydramine - chemical synthesis misc Diazepam - standards misc Pharmaceutical Preparations - chemical synthesis misc Diphenhydramine - standards misc Lidocaine - standards misc Chemistry, Pharmaceutical - methods misc Diazepam - chemical synthesis misc Lidocaine - chemical synthesis
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title	On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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title_full	On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
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title_sort	on-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
title_auth	On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
abstract	Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
abstractGer	Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
abstract_unstemmed	Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
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title_short	On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
url	http://dx.doi.org/10.1126/science.aaf1337 http://www.ncbi.nlm.nih.gov/pubmed/27034366 http://search.proquest.com/docview/1778096101
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up_date	2024-07-04T05:46:58.492Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1975102010</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230714191403.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160609s2016 xx \|\|\|\|\| 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1126/science.aaf1337</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160610</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1975102010</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1975102010</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1440-730de568209890786d8c3bbe5a4fcb059a7857bb8b6ddcabf52681aa4c9f911c0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0063888920160000352628100061ondemandcontinuousflowproductionofpharmaceuticalsi</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">500</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">LING</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Andrea Adamo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo et al. now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution. Science, this issue p. 61; see also p. 44 Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. 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