Messenger RNA modifications: Form, distribution, and function

RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ)...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Wendy V Gilbert [verfasserIn] Tristan A Bell Cassandra Schaening

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Rechteinformationen:	Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science

Schlagwörter:	5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 352(2016), 6292, Seite 1408-1412
Übergeordnetes Werk:	volume:352 ; year:2016 ; number:6292 ; pages:1408-1412

Links:	Volltext Link aufrufen Link aufrufen

DOI / URN:	10.1126/science.aad8711

Katalog-ID:	OLC1977627900

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publishDate	2016
allfields	10.1126/science.aad8711 doi PQ20160719 (DE-627)OLC1977627900 (DE-599)GBVOLC1977627900 (PRQ)c2037-78932a25f4ffda273e202e8c1692aea4134d3265269a7c25cbe64af8cb11d86e0 (KEY)0063888920160000352629201408messengerrnamodificationsformdistributionandfuncti DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wendy V Gilbert verfasserin aut Messenger RNA modifications: Form, distribution, and function 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA Tristan A Bell oth Cassandra Schaening oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6292, Seite 1408-1412 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6292 pages:1408-1412 http://dx.doi.org/10.1126/science.aad8711 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6292 1408-1412
spelling	10.1126/science.aad8711 doi PQ20160719 (DE-627)OLC1977627900 (DE-599)GBVOLC1977627900 (PRQ)c2037-78932a25f4ffda273e202e8c1692aea4134d3265269a7c25cbe64af8cb11d86e0 (KEY)0063888920160000352629201408messengerrnamodificationsformdistributionandfuncti DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wendy V Gilbert verfasserin aut Messenger RNA modifications: Form, distribution, and function 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA Tristan A Bell oth Cassandra Schaening oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6292, Seite 1408-1412 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6292 pages:1408-1412 http://dx.doi.org/10.1126/science.aad8711 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6292 1408-1412
allfields_unstemmed	10.1126/science.aad8711 doi PQ20160719 (DE-627)OLC1977627900 (DE-599)GBVOLC1977627900 (PRQ)c2037-78932a25f4ffda273e202e8c1692aea4134d3265269a7c25cbe64af8cb11d86e0 (KEY)0063888920160000352629201408messengerrnamodificationsformdistributionandfuncti DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wendy V Gilbert verfasserin aut Messenger RNA modifications: Form, distribution, and function 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA Tristan A Bell oth Cassandra Schaening oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6292, Seite 1408-1412 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6292 pages:1408-1412 http://dx.doi.org/10.1126/science.aad8711 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6292 1408-1412
allfieldsGer	10.1126/science.aad8711 doi PQ20160719 (DE-627)OLC1977627900 (DE-599)GBVOLC1977627900 (PRQ)c2037-78932a25f4ffda273e202e8c1692aea4134d3265269a7c25cbe64af8cb11d86e0 (KEY)0063888920160000352629201408messengerrnamodificationsformdistributionandfuncti DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wendy V Gilbert verfasserin aut Messenger RNA modifications: Form, distribution, and function 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA Tristan A Bell oth Cassandra Schaening oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6292, Seite 1408-1412 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6292 pages:1408-1412 http://dx.doi.org/10.1126/science.aad8711 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6292 1408-1412
allfieldsSound	10.1126/science.aad8711 doi PQ20160719 (DE-627)OLC1977627900 (DE-599)GBVOLC1977627900 (PRQ)c2037-78932a25f4ffda273e202e8c1692aea4134d3265269a7c25cbe64af8cb11d86e0 (KEY)0063888920160000352629201408messengerrnamodificationsformdistributionandfuncti DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wendy V Gilbert verfasserin aut Messenger RNA modifications: Form, distribution, and function 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. © COPYRIGHT 2016 American Association for the Advancement of Science 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA Tristan A Bell oth Cassandra Schaening oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 352(2016), 6292, Seite 1408-1412 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:352 year:2016 number:6292 pages:1408-1412 http://dx.doi.org/10.1126/science.aad8711 Volltext http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 352 2016 6292 1408-1412
language	English
source	Enthalten in Science 352(2016), 6292, Seite 1408-1412 volume:352 year:2016 number:6292 pages:1408-1412
sourceStr	Enthalten in Science 352(2016), 6292, Seite 1408-1412 volume:352 year:2016 number:6292 pages:1408-1412
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Wendy V Gilbert @@aut@@ Tristan A Bell @@oth@@ Cassandra Schaening @@oth@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1977627900
language_de	englisch
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author	Wendy V Gilbert
spellingShingle	Wendy V Gilbert ddc 500 fid LING misc 5-Methylcytosine - chemistry misc RNA, Messenger - metabolism misc Methyltransferases - metabolism misc Adenosine - analogs & derivatives misc Pseudouridine - chemistry misc Pseudouridine - metabolism misc Adenosine - chemistry misc RNA, Messenger - chemistry misc 5-Methylcytosine - metabolism misc Adenosine - metabolism misc Messenger RNA Messenger RNA modifications: Form, distribution, and function
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topic_title	500 DNB LING fid Messenger RNA modifications: Form, distribution, and function 5-Methylcytosine - chemistry RNA, Messenger - metabolism Methyltransferases - metabolism Adenosine - analogs & derivatives Pseudouridine - chemistry Pseudouridine - metabolism Adenosine - chemistry RNA, Messenger - chemistry 5-Methylcytosine - metabolism Adenosine - metabolism Messenger RNA
topic	ddc 500 fid LING misc 5-Methylcytosine - chemistry misc RNA, Messenger - metabolism misc Methyltransferases - metabolism misc Adenosine - analogs & derivatives misc Pseudouridine - chemistry misc Pseudouridine - metabolism misc Adenosine - chemistry misc RNA, Messenger - chemistry misc 5-Methylcytosine - metabolism misc Adenosine - metabolism misc Messenger RNA
topic_unstemmed	ddc 500 fid LING misc 5-Methylcytosine - chemistry misc RNA, Messenger - metabolism misc Methyltransferases - metabolism misc Adenosine - analogs & derivatives misc Pseudouridine - chemistry misc Pseudouridine - metabolism misc Adenosine - chemistry misc RNA, Messenger - chemistry misc 5-Methylcytosine - metabolism misc Adenosine - metabolism misc Messenger RNA
topic_browse	ddc 500 fid LING misc 5-Methylcytosine - chemistry misc RNA, Messenger - metabolism misc Methyltransferases - metabolism misc Adenosine - analogs & derivatives misc Pseudouridine - chemistry misc Pseudouridine - metabolism misc Adenosine - chemistry misc RNA, Messenger - chemistry misc 5-Methylcytosine - metabolism misc Adenosine - metabolism misc Messenger RNA
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title	Messenger RNA modifications: Form, distribution, and function
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title_full	Messenger RNA modifications: Form, distribution, and function
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title_sort	messenger rna modifications: form, distribution, and function
title_auth	Messenger RNA modifications: Form, distribution, and function
abstract	RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
abstractGer	RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
abstract_unstemmed	RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNAs in translation and splicing. Recent technical advances have revealed widespread and sparse modification of messenger RNAs with N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ). Here we discuss the rapidly evolving understanding of the location, regulation, and function of these dynamic mRNA marks, collectively termed the epitranscriptome. We highlight differences among modifications and between species that could instruct ongoing efforts to understand how specific mRNA target sites are selected and how their modification is regulated. Diverse molecular consequences of individual m6A modifications are beginning to be revealed, but the effects of m5C and Ψ remain largely unknown. Future work linking molecular effects to organismal phenotypes will broaden our understanding of mRNA modifications as cell and developmental regulators.
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container_issue	6292
title_short	Messenger RNA modifications: Form, distribution, and function
url	http://dx.doi.org/10.1126/science.aad8711 http://www.ncbi.nlm.nih.gov/pubmed/27313037 http://search.proquest.com/docview/1799274352
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