Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system
Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and inv...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pinto‐Teixeira, Filipe [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Rechteinformationen: |
Nutzungsrecht: © 2016 Federation of European Biochemical Societies © 2016 Federation of European Biochemical Societies. |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: FEBS letters - Amsterdam [u.a.] : Elsevier, 1968, 590(2016), 15, Seite 2435-2453 |
|---|---|
| Übergeordnetes Werk: |
volume:590 ; year:2016 ; number:15 ; pages:2435-2453 |
| Links: |
|---|
| DOI / URN: |
10.1002/1873-3468.12298 |
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OLC1981715266 |
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| 520 | |a Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information. | ||
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10.1002/1873-3468.12298 doi PQ20161012 (DE-627)OLC1981715266 (DE-599)GBVOLC1981715266 (PRQ)p1188-bea3b6a79b07b15e8abd1fa98d46376b2b8cf04dd6bc20d246cac01f06b57b80 (KEY)0045922420160000590001502435programmedcelldeathactsatdifferentstagesofdrosophi DE-627 ger DE-627 rakwb eng 570 530 610 DE-600 Pinto‐Teixeira, Filipe verfasserin aut Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information. Nutzungsrecht: © 2016 Federation of European Biochemical Societies © 2016 Federation of European Biochemical Societies. neurodevelopment Drosophila apoptosis Konstantinides, Nikolaos oth Desplan, Claude oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 590(2016), 15, Seite 2435-2453 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:590 year:2016 number:15 pages:2435-2453 http://dx.doi.org/10.1002/1873-3468.12298 Volltext http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12298/abstract http://www.ncbi.nlm.nih.gov/pubmed/27404003 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 590 2016 15 2435-2453 |
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programmed cell death acts at different stages of drosophila neurodevelopment to shape the central nervous system |
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Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system |
| abstract |
Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information. |
| abstractGer |
Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information. |
| abstract_unstemmed |
Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death ( PCD ). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information. |
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GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 |
| container_issue |
15 |
| title_short |
Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system |
| url |
http://dx.doi.org/10.1002/1873-3468.12298 http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12298/abstract http://www.ncbi.nlm.nih.gov/pubmed/27404003 |
| remote_bool |
false |
| author2 |
Konstantinides, Nikolaos Desplan, Claude |
| author2Str |
Konstantinides, Nikolaos Desplan, Claude |
| ppnlink |
129522023 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth |
| doi_str |
10.1002/1873-3468.12298 |
| up_date |
2024-07-03T14:25:16.149Z |
| _version_ |
1803568248155799552 |
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7.40166 |