Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chun-Kan Chen [verfasserIn] Mario Blanco Constanza Jackson Erik Aznauryan Noah Ollikainen Christine Surka Amy Chow Andrea Cerase Patrick McDonel Mitchell Guttman

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 354(2016), 6311, Seite 468-472
Übergeordnetes Werk:	volume:354 ; year:2016 ; number:6311 ; pages:468-472

Links:	Volltext Link aufrufen

DOI / URN:	10.1126/science.aae0047

Katalog-ID:	OLC1984807196

Internformat


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520			\|a Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription.
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allfields	10.1126/science.aae0047 doi PQ20161201 (DE-627)OLC1984807196 (DE-599)GBVOLC1984807196 (PRQ)c1215-9cb4cba0481e293c4757c0a750a18e29c9c50bb1f436a3e3b226df24371c80a10 (KEY)0063888920160000354631100468xistrecruitsthexchromosometothenuclearlaminatoenab DE-627 ger DE-627 rakwb eng 500 DNB LING fid Chun-Kan Chen verfasserin aut Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription. Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes Mario Blanco oth Constanza Jackson oth Erik Aznauryan oth Noah Ollikainen oth Christine Surka oth Amy Chow oth Andrea Cerase oth Patrick McDonel oth Mitchell Guttman oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 354(2016), 6311, Seite 468-472 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:354 year:2016 number:6311 pages:468-472 http://dx.doi.org/10.1126/science.aae0047 Volltext http://search.proquest.com/docview/1833165925 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 354 2016 6311 468-472
spelling	10.1126/science.aae0047 doi PQ20161201 (DE-627)OLC1984807196 (DE-599)GBVOLC1984807196 (PRQ)c1215-9cb4cba0481e293c4757c0a750a18e29c9c50bb1f436a3e3b226df24371c80a10 (KEY)0063888920160000354631100468xistrecruitsthexchromosometothenuclearlaminatoenab DE-627 ger DE-627 rakwb eng 500 DNB LING fid Chun-Kan Chen verfasserin aut Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription. Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes Mario Blanco oth Constanza Jackson oth Erik Aznauryan oth Noah Ollikainen oth Christine Surka oth Amy Chow oth Andrea Cerase oth Patrick McDonel oth Mitchell Guttman oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 354(2016), 6311, Seite 468-472 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:354 year:2016 number:6311 pages:468-472 http://dx.doi.org/10.1126/science.aae0047 Volltext http://search.proquest.com/docview/1833165925 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 354 2016 6311 468-472
allfields_unstemmed	10.1126/science.aae0047 doi PQ20161201 (DE-627)OLC1984807196 (DE-599)GBVOLC1984807196 (PRQ)c1215-9cb4cba0481e293c4757c0a750a18e29c9c50bb1f436a3e3b226df24371c80a10 (KEY)0063888920160000354631100468xistrecruitsthexchromosometothenuclearlaminatoenab DE-627 ger DE-627 rakwb eng 500 DNB LING fid Chun-Kan Chen verfasserin aut Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription. Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes Mario Blanco oth Constanza Jackson oth Erik Aznauryan oth Noah Ollikainen oth Christine Surka oth Amy Chow oth Andrea Cerase oth Patrick McDonel oth Mitchell Guttman oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 354(2016), 6311, Seite 468-472 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:354 year:2016 number:6311 pages:468-472 http://dx.doi.org/10.1126/science.aae0047 Volltext http://search.proquest.com/docview/1833165925 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 354 2016 6311 468-472
allfieldsGer	10.1126/science.aae0047 doi PQ20161201 (DE-627)OLC1984807196 (DE-599)GBVOLC1984807196 (PRQ)c1215-9cb4cba0481e293c4757c0a750a18e29c9c50bb1f436a3e3b226df24371c80a10 (KEY)0063888920160000354631100468xistrecruitsthexchromosometothenuclearlaminatoenab DE-627 ger DE-627 rakwb eng 500 DNB LING fid Chun-Kan Chen verfasserin aut Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription. Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes Mario Blanco oth Constanza Jackson oth Erik Aznauryan oth Noah Ollikainen oth Christine Surka oth Amy Chow oth Andrea Cerase oth Patrick McDonel oth Mitchell Guttman oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 354(2016), 6311, Seite 468-472 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:354 year:2016 number:6311 pages:468-472 http://dx.doi.org/10.1126/science.aae0047 Volltext http://search.proquest.com/docview/1833165925 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 354 2016 6311 468-472
allfieldsSound	10.1126/science.aae0047 doi PQ20161201 (DE-627)OLC1984807196 (DE-599)GBVOLC1984807196 (PRQ)c1215-9cb4cba0481e293c4757c0a750a18e29c9c50bb1f436a3e3b226df24371c80a10 (KEY)0063888920160000354631100468xistrecruitsthexchromosometothenuclearlaminatoenab DE-627 ger DE-627 rakwb eng 500 DNB LING fid Chun-Kan Chen verfasserin aut Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription. Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes Mario Blanco oth Constanza Jackson oth Erik Aznauryan oth Noah Ollikainen oth Christine Surka oth Amy Chow oth Andrea Cerase oth Patrick McDonel oth Mitchell Guttman oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 354(2016), 6311, Seite 468-472 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:354 year:2016 number:6311 pages:468-472 http://dx.doi.org/10.1126/science.aae0047 Volltext http://search.proquest.com/docview/1833165925 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 354 2016 6311 468-472
language	English
source	Enthalten in Science 354(2016), 6311, Seite 468-472 volume:354 year:2016 number:6311 pages:468-472
sourceStr	Enthalten in Science 354(2016), 6311, Seite 468-472 volume:354 year:2016 number:6311 pages:468-472
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Chun-Kan Chen @@aut@@ Mario Blanco @@oth@@ Constanza Jackson @@oth@@ Erik Aznauryan @@oth@@ Noah Ollikainen @@oth@@ Christine Surka @@oth@@ Amy Chow @@oth@@ Andrea Cerase @@oth@@ Patrick McDonel @@oth@@ Mitchell Guttman @@oth@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1984807196
language_de	englisch
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author	Chun-Kan Chen
spellingShingle	Chun-Kan Chen ddc 500 fid LING misc Gene expression misc Cellular biology misc Ribonucleic acid--RNA misc Chromosomes Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
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topic_title	500 DNB LING fid Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing Gene expression Cellular biology Ribonucleic acid--RNA Chromosomes
topic	ddc 500 fid LING misc Gene expression misc Cellular biology misc Ribonucleic acid--RNA misc Chromosomes
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title	Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
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title_full	Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
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title_sort	xist recruits the x chromosome to the nuclear lamina to enable chromosome-wide silencing
title_auth	Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
abstract	Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription.
abstractGer	Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription.
abstract_unstemmed	Female mammals have two X chromosomes. One must be silenced to "balance" gene dosage with male XY cells. The Xist long noncoding RNA coats the inactive X chromosome in female mammalian cells. Chen et al. show that the Xist RNA helps recruit the X chromosome to the internal rim of the cell nucleus, a region where gene expression is silenced. Xist is recruited to the domain through an interaction with the Lamin B receptor. This recruitment allows the Xist RNA to spread across the future inactive X chromosome, shutting down gene expression. Science, this issue p. 468 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription.
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container_issue	6311
title_short	Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
url	http://dx.doi.org/10.1126/science.aae0047 http://search.proquest.com/docview/1833165925
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author2	Mario Blanco Constanza Jackson Erik Aznauryan Noah Ollikainen Christine Surka Amy Chow Andrea Cerase Patrick McDonel Mitchell Guttman
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score	7.399646

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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

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