Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways

Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a ce...
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Autor*in:	Diana Teixeira [verfasserIn] Cláudia Marques Diogo Pestana Ana Faria Sónia Norberto Conceição Calhau Rosário Monteiro

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	Enthalten in: Environmental toxicology - New York, NY : Wiley, 1999, 31(2016), 11, Seite 1496
Übergeordnetes Werk:	volume:31 ; year:2016 ; number:11 ; pages:1496

Links:	Volltext Link aufrufen

DOI / URN:	10.1002/tox.22154

Katalog-ID:	OLC198555366X

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allfieldsGer	10.1002/tox.22154 doi PQ20161201 (DE-627)OLC198555366X (DE-599)GBVOLC198555366X (PRQ)p1464-83e9892c76ca11ccc401ad3bbdc62740a4b6c46c1fd4f85fdedbb350dc5491453 (KEY)0154138220160000031001101496effectsofxenoestrogensinhumanm1andm2macrophagemigr DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Diana Teixeira verfasserin aut Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a central role. This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. Some of the effects described above were shown to be mediated by either ER[alpha] or ER[beta] and were simultaneous to modulation of NF-[kappa]B, AP1, JNK, or ERK signaling pathways. We provide new evidence of the effect of XE on macrophage behavior and their mechanisms with relevance to the understanding of the action of environmental chemicals on the immune system and inflammation-associated diseases. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1496-1509, 2016. Cláudia Marques oth Diogo Pestana oth Ana Faria oth Sónia Norberto oth Conceição Calhau oth Rosário Monteiro oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 31(2016), 11, Seite 1496 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:31 year:2016 number:11 pages:1496 http://dx.doi.org/10.1002/tox.22154 Volltext http://search.proquest.com/docview/1829749493 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 31 2016 11 1496
allfieldsSound	10.1002/tox.22154 doi PQ20161201 (DE-627)OLC198555366X (DE-599)GBVOLC198555366X (PRQ)p1464-83e9892c76ca11ccc401ad3bbdc62740a4b6c46c1fd4f85fdedbb350dc5491453 (KEY)0154138220160000031001101496effectsofxenoestrogensinhumanm1andm2macrophagemigr DE-627 ger DE-627 rakwb eng 690 ZDB 43.00 bkl Diana Teixeira verfasserin aut Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a central role. This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. Some of the effects described above were shown to be mediated by either ER[alpha] or ER[beta] and were simultaneous to modulation of NF-[kappa]B, AP1, JNK, or ERK signaling pathways. We provide new evidence of the effect of XE on macrophage behavior and their mechanisms with relevance to the understanding of the action of environmental chemicals on the immune system and inflammation-associated diseases. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1496-1509, 2016. Cláudia Marques oth Diogo Pestana oth Ana Faria oth Sónia Norberto oth Conceição Calhau oth Rosário Monteiro oth Enthalten in Environmental toxicology New York, NY : Wiley, 1999 31(2016), 11, Seite 1496 (DE-627)254912214 (DE-600)1463449-1 (DE-576)079598412 1520-4081 nnns volume:31 year:2016 number:11 pages:1496 http://dx.doi.org/10.1002/tox.22154 Volltext http://search.proquest.com/docview/1829749493 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4219 43.00 AVZ AR 31 2016 11 1496
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source	Enthalten in Environmental toxicology 31(2016), 11, Seite 1496 volume:31 year:2016 number:11 pages:1496
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This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. 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author	Diana Teixeira
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title	Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways
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title_full	Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways
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title_sort	effects of xenoestrogens in human m1 and m2 macrophage migration, cytokine release, and estrogen-related signaling pathways
title_auth	Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways
abstract	Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a central role. This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. Some of the effects described above were shown to be mediated by either ER[alpha] or ER[beta] and were simultaneous to modulation of NF-[kappa]B, AP1, JNK, or ERK signaling pathways. We provide new evidence of the effect of XE on macrophage behavior and their mechanisms with relevance to the understanding of the action of environmental chemicals on the immune system and inflammation-associated diseases. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1496-1509, 2016.
abstractGer	Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a central role. This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. Some of the effects described above were shown to be mediated by either ER[alpha] or ER[beta] and were simultaneous to modulation of NF-[kappa]B, AP1, JNK, or ERK signaling pathways. We provide new evidence of the effect of XE on macrophage behavior and their mechanisms with relevance to the understanding of the action of environmental chemicals on the immune system and inflammation-associated diseases. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1496-1509, 2016.
abstract_unstemmed	Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially involved mechanism and where macrophages play a central role. This study was carried out to evaluate if xenoestrogen (XE) treatment of classically (M1) or alternatively (M2) activated macrophages could affect their behavior. For this purpose, human peripheral blood monocyte-derived macrophages either unstimulated or activated with lipopolysaccharide (100 ng/mL, M1) or with interleukin (IL) 4 (15 ng/mL, M2) were treated with 17[beta]-estradiol (E2), BPA, DEHP and DBP alone or in combination with selective ER[alpha] or ER[beta] antagonists. Migratory capability, cytokine release, and estrogen-associated signaling pathways were evaluated to assess macrophage function. All tested XEs had a tendency to stimulate M2 migration, an effect that followed the same direction than E2. Moreover, all XEs significantly induced IL10 in M1 and decreased IL6 and globally decreased IL10, IL6, TNF[alpha], and IL1[beta] release by M2 macrophages. However, DEHP and DBP significantly increased IL1[beta] release in M1 and M2 macrophages, respectively. Some of the effects described above were shown to be mediated by either ER[alpha] or ER[beta] and were simultaneous to modulation of NF-[kappa]B, AP1, JNK, or ERK signaling pathways. We provide new evidence of the effect of XE on macrophage behavior and their mechanisms with relevance to the understanding of the action of environmental chemicals on the immune system and inflammation-associated diseases. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1496-1509, 2016.
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title_short	Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways
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