Drug Release Kinetics and Mechanism from PLGA Formulations
The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations wa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ji, Yuanhui [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Rechteinformationen: |
Nutzungsrecht: © 2016 American Institute of Chemical Engineers |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: AIChE journal - Hoboken, NJ : Wiley-Blackwell, 1955, 62(2016), 11, Seite 4055-4065 |
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| Übergeordnetes Werk: |
volume:62 ; year:2016 ; number:11 ; pages:4055-4065 |
| Links: |
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| DOI / URN: |
10.1002/aic.15282 |
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OLC1986382052 |
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| 520 | |a The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 | ||
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| 650 | 4 | |a amorphous formulations | |
| 650 | 4 | |a indomethacin | |
| 650 | 4 | |a poorly soluble pharmaceutical | |
| 650 | 4 | |a PLGA | |
| 650 | 4 | |a chemical‐potential‐gradient model | |
| 650 | 4 | |a hydrochlorothiazide | |
| 650 | 4 | |a drug release mechanism | |
| 700 | 1 | |a Lesniak, Anna Katharina |4 oth | |
| 700 | 1 | |a Prudic, Anke |4 oth | |
| 700 | 1 | |a Paus, Raphael |4 oth | |
| 700 | 1 | |a Sadowski, Gabriele |4 oth | |
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10.1002/aic.15282 doi PQ20161201 (DE-627)OLC1986382052 (DE-599)GBVOLC1986382052 (PRQ)c2356-e038c3253010cfb956cbab3ed3da0388fc99f65115f9ea0b0969c7d8ab8e770e3 (KEY)0553148920160000062001104055drugreleasekineticsandmechanismfromplgaformulation DE-627 ger DE-627 rakwb eng 660 DE-600 58.00 bkl Ji, Yuanhui verfasserin aut Drug Release Kinetics and Mechanism from PLGA Formulations 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 Nutzungsrecht: © 2016 American Institute of Chemical Engineers PC‐SAFT amorphous formulations indomethacin poorly soluble pharmaceutical PLGA chemical‐potential‐gradient model hydrochlorothiazide drug release mechanism Lesniak, Anna Katharina oth Prudic, Anke oth Paus, Raphael oth Sadowski, Gabriele oth Enthalten in AIChE journal Hoboken, NJ : Wiley-Blackwell, 1955 62(2016), 11, Seite 4055-4065 (DE-627)129590495 (DE-600)240008-X (DE-576)015082997 0001-1541 nnns volume:62 year:2016 number:11 pages:4055-4065 http://dx.doi.org/10.1002/aic.15282 Volltext http://onlinelibrary.wiley.com/doi/10.1002/aic.15282/abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2016 58.00 AVZ AR 62 2016 11 4055-4065 |
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10.1002/aic.15282 doi PQ20161201 (DE-627)OLC1986382052 (DE-599)GBVOLC1986382052 (PRQ)c2356-e038c3253010cfb956cbab3ed3da0388fc99f65115f9ea0b0969c7d8ab8e770e3 (KEY)0553148920160000062001104055drugreleasekineticsandmechanismfromplgaformulation DE-627 ger DE-627 rakwb eng 660 DE-600 58.00 bkl Ji, Yuanhui verfasserin aut Drug Release Kinetics and Mechanism from PLGA Formulations 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 Nutzungsrecht: © 2016 American Institute of Chemical Engineers PC‐SAFT amorphous formulations indomethacin poorly soluble pharmaceutical PLGA chemical‐potential‐gradient model hydrochlorothiazide drug release mechanism Lesniak, Anna Katharina oth Prudic, Anke oth Paus, Raphael oth Sadowski, Gabriele oth Enthalten in AIChE journal Hoboken, NJ : Wiley-Blackwell, 1955 62(2016), 11, Seite 4055-4065 (DE-627)129590495 (DE-600)240008-X (DE-576)015082997 0001-1541 nnns volume:62 year:2016 number:11 pages:4055-4065 http://dx.doi.org/10.1002/aic.15282 Volltext http://onlinelibrary.wiley.com/doi/10.1002/aic.15282/abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2016 58.00 AVZ AR 62 2016 11 4055-4065 |
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10.1002/aic.15282 doi PQ20161201 (DE-627)OLC1986382052 (DE-599)GBVOLC1986382052 (PRQ)c2356-e038c3253010cfb956cbab3ed3da0388fc99f65115f9ea0b0969c7d8ab8e770e3 (KEY)0553148920160000062001104055drugreleasekineticsandmechanismfromplgaformulation DE-627 ger DE-627 rakwb eng 660 DE-600 58.00 bkl Ji, Yuanhui verfasserin aut Drug Release Kinetics and Mechanism from PLGA Formulations 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 Nutzungsrecht: © 2016 American Institute of Chemical Engineers PC‐SAFT amorphous formulations indomethacin poorly soluble pharmaceutical PLGA chemical‐potential‐gradient model hydrochlorothiazide drug release mechanism Lesniak, Anna Katharina oth Prudic, Anke oth Paus, Raphael oth Sadowski, Gabriele oth Enthalten in AIChE journal Hoboken, NJ : Wiley-Blackwell, 1955 62(2016), 11, Seite 4055-4065 (DE-627)129590495 (DE-600)240008-X (DE-576)015082997 0001-1541 nnns volume:62 year:2016 number:11 pages:4055-4065 http://dx.doi.org/10.1002/aic.15282 Volltext http://onlinelibrary.wiley.com/doi/10.1002/aic.15282/abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2016 58.00 AVZ AR 62 2016 11 4055-4065 |
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10.1002/aic.15282 doi PQ20161201 (DE-627)OLC1986382052 (DE-599)GBVOLC1986382052 (PRQ)c2356-e038c3253010cfb956cbab3ed3da0388fc99f65115f9ea0b0969c7d8ab8e770e3 (KEY)0553148920160000062001104055drugreleasekineticsandmechanismfromplgaformulation DE-627 ger DE-627 rakwb eng 660 DE-600 58.00 bkl Ji, Yuanhui verfasserin aut Drug Release Kinetics and Mechanism from PLGA Formulations 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 Nutzungsrecht: © 2016 American Institute of Chemical Engineers PC‐SAFT amorphous formulations indomethacin poorly soluble pharmaceutical PLGA chemical‐potential‐gradient model hydrochlorothiazide drug release mechanism Lesniak, Anna Katharina oth Prudic, Anke oth Paus, Raphael oth Sadowski, Gabriele oth Enthalten in AIChE journal Hoboken, NJ : Wiley-Blackwell, 1955 62(2016), 11, Seite 4055-4065 (DE-627)129590495 (DE-600)240008-X (DE-576)015082997 0001-1541 nnns volume:62 year:2016 number:11 pages:4055-4065 http://dx.doi.org/10.1002/aic.15282 Volltext http://onlinelibrary.wiley.com/doi/10.1002/aic.15282/abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2016 58.00 AVZ AR 62 2016 11 4055-4065 |
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10.1002/aic.15282 doi PQ20161201 (DE-627)OLC1986382052 (DE-599)GBVOLC1986382052 (PRQ)c2356-e038c3253010cfb956cbab3ed3da0388fc99f65115f9ea0b0969c7d8ab8e770e3 (KEY)0553148920160000062001104055drugreleasekineticsandmechanismfromplgaformulation DE-627 ger DE-627 rakwb eng 660 DE-600 58.00 bkl Ji, Yuanhui verfasserin aut Drug Release Kinetics and Mechanism from PLGA Formulations 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 Nutzungsrecht: © 2016 American Institute of Chemical Engineers PC‐SAFT amorphous formulations indomethacin poorly soluble pharmaceutical PLGA chemical‐potential‐gradient model hydrochlorothiazide drug release mechanism Lesniak, Anna Katharina oth Prudic, Anke oth Paus, Raphael oth Sadowski, Gabriele oth Enthalten in AIChE journal Hoboken, NJ : Wiley-Blackwell, 1955 62(2016), 11, Seite 4055-4065 (DE-627)129590495 (DE-600)240008-X (DE-576)015082997 0001-1541 nnns volume:62 year:2016 number:11 pages:4055-4065 http://dx.doi.org/10.1002/aic.15282 Volltext http://onlinelibrary.wiley.com/doi/10.1002/aic.15282/abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2016 58.00 AVZ AR 62 2016 11 4055-4065 |
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Drug Release Kinetics and Mechanism from PLGA Formulations |
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The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 |
| abstractGer |
The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 |
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The release kinetics of indomethacin (IND) and hydrochlorothiazide (HCT) from drug/PLGA formulations with different copolymer composition and molecular weight of PLGA were measured in vitro by using a rotating disk system (USP II). The release mechanism of IND and HCT from their PLGA formulations was analyzed using a chemical‐potential‐gradient model combined with the Perturbed‐Chain Statistical Associating Fluid Theory (PC‐SAFT). Furthermore, the release kinetics of IND and HCT from the PLGA formulations with different copolymer composition and molecular weight of PLGA were correlated and predicted in good accordance with the experimental data. It was found that the chemical‐potential‐gradient model combined with the PC‐SAFT helped to understand the drug release mechanism from the drug/PLGA formulations. It also well correlated and predicted the drug release kinetics as function of copolymer composition and molecular weight of PLGA as well as of drug type. It helps to save time and costs for determination of the long‐term drug release kinetics, especially for sustained drug release as obtained from the drug/PLGA formulations in this work. © 2016 American Institute of Chemical Engineers AIChE J , 62: 4055–4065, 2016 |
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Drug Release Kinetics and Mechanism from PLGA Formulations |
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