FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its cl...
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Autor*in:	Fu, Xiaoyong [verfasserIn] Jeselsohn, Rinath Pereira, Resel Hollingsworth, Emporia F Creighton, Chad J Li, Fugen Shea, Martin Nardone, Agostina De Angelis, Carmine Heiser, Laura M Anur, Pavana Wang, Nicholas Grasso, Catherine S Spellman, Paul T Griffith, Obi L Tsimelzon, Anna Gutierrez, Carolina Huang, Shixia Edwards, Dean P Trivedi, Meghana V Rimawi, Mothaffar F Lopez-Terrada, Dolores Hilsenbeck, Susan G Gray, Joe W Brown, Myles Osborne, C. Kent Schiff, Rachel

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression

Übergeordnetes Werk:	Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 113(2016), 43, Seite E6600-E6609
Übergeordnetes Werk:	volume:113 ; year:2016 ; number:43 ; pages:E6600-E6609

Links:	Volltext Link aufrufen

DOI / URN:	10.1073/pnas.1612835113

Katalog-ID:	OLC1986419118

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520			\|a Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors.
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650		4	\|a Estrogen
650		4	\|a Protein expression
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700	1		\|a Li, Fugen \|4 oth
700	1		\|a Shea, Martin \|4 oth
700	1		\|a Nardone, Agostina \|4 oth
700	1		\|a De Angelis, Carmine \|4 oth
700	1		\|a Heiser, Laura M \|4 oth
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700	1		\|a Edwards, Dean P \|4 oth
700	1		\|a Trivedi, Meghana V \|4 oth
700	1		\|a Rimawi, Mothaffar F \|4 oth
700	1		\|a Lopez-Terrada, Dolores \|4 oth
700	1		\|a Hilsenbeck, Susan G \|4 oth
700	1		\|a Gray, Joe W \|4 oth
700	1		\|a Brown, Myles \|4 oth
700	1		\|a Osborne, C. Kent \|4 oth
700	1		\|a Schiff, Rachel \|4 oth
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allfields	10.1073/pnas.1612835113 doi PQ20161201 (DE-627)OLC1986419118 (DE-599)GBVOLC1986419118 (PRQ)c1280-ddb641258c32a9890a104a13c86616598d01557f5266cfdeb3d8a030083360fe0 (KEY)0583363920160000113004306600foxa1overexpressionmediatesendocrineresistancebyal DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Fu, Xiaoyong verfasserin aut FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors. Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression Jeselsohn, Rinath oth Pereira, Resel oth Hollingsworth, Emporia F oth Creighton, Chad J oth Li, Fugen oth Shea, Martin oth Nardone, Agostina oth De Angelis, Carmine oth Heiser, Laura M oth Anur, Pavana oth Wang, Nicholas oth Grasso, Catherine S oth Spellman, Paul T oth Griffith, Obi L oth Tsimelzon, Anna oth Gutierrez, Carolina oth Huang, Shixia oth Edwards, Dean P oth Trivedi, Meghana V oth Rimawi, Mothaffar F oth Lopez-Terrada, Dolores oth Hilsenbeck, Susan G oth Gray, Joe W oth Brown, Myles oth Osborne, C. Kent oth Schiff, Rachel oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 113(2016), 43, Seite E6600-E6609 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:113 year:2016 number:43 pages:E6600-E6609 http://dx.doi.org/10.1073/pnas.1612835113 Volltext http://search.proquest.com/docview/1835926009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 113 2016 43 E6600-E6609
spelling	10.1073/pnas.1612835113 doi PQ20161201 (DE-627)OLC1986419118 (DE-599)GBVOLC1986419118 (PRQ)c1280-ddb641258c32a9890a104a13c86616598d01557f5266cfdeb3d8a030083360fe0 (KEY)0583363920160000113004306600foxa1overexpressionmediatesendocrineresistancebyal DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Fu, Xiaoyong verfasserin aut FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors. Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression Jeselsohn, Rinath oth Pereira, Resel oth Hollingsworth, Emporia F oth Creighton, Chad J oth Li, Fugen oth Shea, Martin oth Nardone, Agostina oth De Angelis, Carmine oth Heiser, Laura M oth Anur, Pavana oth Wang, Nicholas oth Grasso, Catherine S oth Spellman, Paul T oth Griffith, Obi L oth Tsimelzon, Anna oth Gutierrez, Carolina oth Huang, Shixia oth Edwards, Dean P oth Trivedi, Meghana V oth Rimawi, Mothaffar F oth Lopez-Terrada, Dolores oth Hilsenbeck, Susan G oth Gray, Joe W oth Brown, Myles oth Osborne, C. Kent oth Schiff, Rachel oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 113(2016), 43, Seite E6600-E6609 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:113 year:2016 number:43 pages:E6600-E6609 http://dx.doi.org/10.1073/pnas.1612835113 Volltext http://search.proquest.com/docview/1835926009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 113 2016 43 E6600-E6609
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allfieldsGer	10.1073/pnas.1612835113 doi PQ20161201 (DE-627)OLC1986419118 (DE-599)GBVOLC1986419118 (PRQ)c1280-ddb641258c32a9890a104a13c86616598d01557f5266cfdeb3d8a030083360fe0 (KEY)0583363920160000113004306600foxa1overexpressionmediatesendocrineresistancebyal DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Fu, Xiaoyong verfasserin aut FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors. Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression Jeselsohn, Rinath oth Pereira, Resel oth Hollingsworth, Emporia F oth Creighton, Chad J oth Li, Fugen oth Shea, Martin oth Nardone, Agostina oth De Angelis, Carmine oth Heiser, Laura M oth Anur, Pavana oth Wang, Nicholas oth Grasso, Catherine S oth Spellman, Paul T oth Griffith, Obi L oth Tsimelzon, Anna oth Gutierrez, Carolina oth Huang, Shixia oth Edwards, Dean P oth Trivedi, Meghana V oth Rimawi, Mothaffar F oth Lopez-Terrada, Dolores oth Hilsenbeck, Susan G oth Gray, Joe W oth Brown, Myles oth Osborne, C. Kent oth Schiff, Rachel oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 113(2016), 43, Seite E6600-E6609 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:113 year:2016 number:43 pages:E6600-E6609 http://dx.doi.org/10.1073/pnas.1612835113 Volltext http://search.proquest.com/docview/1835926009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 113 2016 43 E6600-E6609
allfieldsSound	10.1073/pnas.1612835113 doi PQ20161201 (DE-627)OLC1986419118 (DE-599)GBVOLC1986419118 (PRQ)c1280-ddb641258c32a9890a104a13c86616598d01557f5266cfdeb3d8a030083360fe0 (KEY)0583363920160000113004306600foxa1overexpressionmediatesendocrineresistancebyal DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Fu, Xiaoyong verfasserin aut FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors. Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression Jeselsohn, Rinath oth Pereira, Resel oth Hollingsworth, Emporia F oth Creighton, Chad J oth Li, Fugen oth Shea, Martin oth Nardone, Agostina oth De Angelis, Carmine oth Heiser, Laura M oth Anur, Pavana oth Wang, Nicholas oth Grasso, Catherine S oth Spellman, Paul T oth Griffith, Obi L oth Tsimelzon, Anna oth Gutierrez, Carolina oth Huang, Shixia oth Edwards, Dean P oth Trivedi, Meghana V oth Rimawi, Mothaffar F oth Lopez-Terrada, Dolores oth Hilsenbeck, Susan G oth Gray, Joe W oth Brown, Myles oth Osborne, C. Kent oth Schiff, Rachel oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 113(2016), 43, Seite E6600-E6609 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:113 year:2016 number:43 pages:E6600-E6609 http://dx.doi.org/10.1073/pnas.1612835113 Volltext http://search.proquest.com/docview/1835926009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 113 2016 43 E6600-E6609
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source	Enthalten in Proceedings of the National Academy of Sciences of the United States of America 113(2016), 43, Seite E6600-E6609 volume:113 year:2016 number:43 pages:E6600-E6609
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topic_facet	Proteins Breast cancer Cell growth Chromatin Estrogen Protein expression
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authorswithroles_txt_mv	Fu, Xiaoyong @@aut@@ Jeselsohn, Rinath @@oth@@ Pereira, Resel @@oth@@ Hollingsworth, Emporia F @@oth@@ Creighton, Chad J @@oth@@ Li, Fugen @@oth@@ Shea, Martin @@oth@@ Nardone, Agostina @@oth@@ De Angelis, Carmine @@oth@@ Heiser, Laura M @@oth@@ Anur, Pavana @@oth@@ Wang, Nicholas @@oth@@ Grasso, Catherine S @@oth@@ Spellman, Paul T @@oth@@ Griffith, Obi L @@oth@@ Tsimelzon, Anna @@oth@@ Gutierrez, Carolina @@oth@@ Huang, Shixia @@oth@@ Edwards, Dean P @@oth@@ Trivedi, Meghana V @@oth@@ Rimawi, Mothaffar F @@oth@@ Lopez-Terrada, Dolores @@oth@@ Hilsenbeck, Susan G @@oth@@ Gray, Joe W @@oth@@ Brown, Myles @@oth@@ Osborne, C. Kent @@oth@@ Schiff, Rachel @@oth@@
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author	Fu, Xiaoyong
spellingShingle	Fu, Xiaoyong ddc 500 ddc 570 fid LING fid BIODIV misc Proteins misc Breast cancer misc Cell growth misc Chromatin misc Estrogen misc Protein expression FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
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title	FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
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title_full	FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
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title_sort	foxa1 overexpression mediates endocrine resistance by altering the er transcriptome and il-8 expression in er-positive breast cancer
title_auth	FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
abstract	Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors.
abstractGer	Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors.
abstract_unstemmed	Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor α (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer is unknown. Here, we report preclinical evidence for a role of FOXA1 in Endo-R breast cancer as well as evidence for its clinical significance. FOXA1 is gene-amplified and/or overexpressed in Endo-R derivatives of several breast cancer cell line models. Induced FOXA1 triggers oncogenic gene signatures and proteomic profiles highly associated with endocrine resistance. Integrated omics data reveal IL8 as one of the most perturbed genes regulated by FOXA1 and ER transcriptional reprogramming in Endo-R cells. IL-8 knockdown inhibits tamoxifen-resistant cell growth and invasion and partially attenuates the effect of overexpressed FOXA1. Our study highlights a role of FOXA1 via IL-8 signaling as a potential therapeutic target in FOXA1-overexpressing ER-positive tumors.
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title_short	FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer
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up_date	2024-07-04T04:37:38.949Z
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FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

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