Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level...
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Autor*in:	UBAID, MUHAMMAD [verfasserIn] ILYAS, SADAF MIR, SADULLAH KHAN, ABIDA K RASHID, REHANA KHAN, MUHAMMAD Z.U KANWAL, ZAINAB G NAWAZ, AHMAD SHAH, AMNA MURTAZA, GHULAM

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science

Übergeordnetes Werk:	Enthalten in: Anais da Academia Brasileira de Ciências - Rio de Janeiro, 1929, 88(2016), 4, Seite 2303-2317
Übergeordnetes Werk:	volume:88 ; year:2016 ; number:4 ; pages:2303-2317

Links:	Volltext Link aufrufen

DOI / URN:	10.1590/0001-3765201620160162

Katalog-ID:	OLC1990304788

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520			\|a ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.
650		4	\|a Biology (General)
650		4	\|a topical gel
650		4	\|a clotrimazole
650		4	\|a Central composite design
650		4	\|a permeability enhancer
650		4	\|a QH301-705.5
650		4	\|a Science
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700	1		\|a KANWAL, ZAINAB G \|4 oth
700	1		\|a NAWAZ, AHMAD \|4 oth
700	1		\|a SHAH, AMNA \|4 oth
700	1		\|a MURTAZA, GHULAM \|4 oth
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allfields	10.1590/0001-3765201620160162 doi PQ20170501 (DE-627)OLC1990304788 (DE-599)GBVOLC1990304788 (PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3 (KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm DE-627 ger DE-627 rakwb eng 000 DNB 500 AVZ 30.00 bkl UBAID, MUHAMMAD verfasserin aut Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin. Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science ILYAS, SADAF oth MIR, SADULLAH oth KHAN, ABIDA K oth RASHID, REHANA oth KHAN, MUHAMMAD Z.U oth KANWAL, ZAINAB G oth NAWAZ, AHMAD oth SHAH, AMNA oth MURTAZA, GHULAM oth Enthalten in Anais da Academia Brasileira de Ciências Rio de Janeiro, 1929 88(2016), 4, Seite 2303-2317 (DE-627)129938955 (DE-600)391417-3 (DE-576)015500713 0001-3765 nnns volume:88 year:2016 number:4 pages:2303-2317 http://dx.doi.org/10.1590/0001-3765201620160162 Volltext https://doaj.org/article/fbb9927493304462861d9b65003487d4 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-IBA SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_40 GBV_ILN_62 GBV_ILN_156 GBV_ILN_2399 30.00 AVZ AR 88 2016 4 2303-2317
spelling	10.1590/0001-3765201620160162 doi PQ20170501 (DE-627)OLC1990304788 (DE-599)GBVOLC1990304788 (PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3 (KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm DE-627 ger DE-627 rakwb eng 000 DNB 500 AVZ 30.00 bkl UBAID, MUHAMMAD verfasserin aut Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin. Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science ILYAS, SADAF oth MIR, SADULLAH oth KHAN, ABIDA K oth RASHID, REHANA oth KHAN, MUHAMMAD Z.U oth KANWAL, ZAINAB G oth NAWAZ, AHMAD oth SHAH, AMNA oth MURTAZA, GHULAM oth Enthalten in Anais da Academia Brasileira de Ciências Rio de Janeiro, 1929 88(2016), 4, Seite 2303-2317 (DE-627)129938955 (DE-600)391417-3 (DE-576)015500713 0001-3765 nnns volume:88 year:2016 number:4 pages:2303-2317 http://dx.doi.org/10.1590/0001-3765201620160162 Volltext https://doaj.org/article/fbb9927493304462861d9b65003487d4 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-IBA SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_40 GBV_ILN_62 GBV_ILN_156 GBV_ILN_2399 30.00 AVZ AR 88 2016 4 2303-2317
allfields_unstemmed	10.1590/0001-3765201620160162 doi PQ20170501 (DE-627)OLC1990304788 (DE-599)GBVOLC1990304788 (PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3 (KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm DE-627 ger DE-627 rakwb eng 000 DNB 500 AVZ 30.00 bkl UBAID, MUHAMMAD verfasserin aut Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin. Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science ILYAS, SADAF oth MIR, SADULLAH oth KHAN, ABIDA K oth RASHID, REHANA oth KHAN, MUHAMMAD Z.U oth KANWAL, ZAINAB G oth NAWAZ, AHMAD oth SHAH, AMNA oth MURTAZA, GHULAM oth Enthalten in Anais da Academia Brasileira de Ciências Rio de Janeiro, 1929 88(2016), 4, Seite 2303-2317 (DE-627)129938955 (DE-600)391417-3 (DE-576)015500713 0001-3765 nnns volume:88 year:2016 number:4 pages:2303-2317 http://dx.doi.org/10.1590/0001-3765201620160162 Volltext https://doaj.org/article/fbb9927493304462861d9b65003487d4 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-IBA SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_40 GBV_ILN_62 GBV_ILN_156 GBV_ILN_2399 30.00 AVZ AR 88 2016 4 2303-2317
allfieldsGer	10.1590/0001-3765201620160162 doi PQ20170501 (DE-627)OLC1990304788 (DE-599)GBVOLC1990304788 (PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3 (KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm DE-627 ger DE-627 rakwb eng 000 DNB 500 AVZ 30.00 bkl UBAID, MUHAMMAD verfasserin aut Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin. Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science ILYAS, SADAF oth MIR, SADULLAH oth KHAN, ABIDA K oth RASHID, REHANA oth KHAN, MUHAMMAD Z.U oth KANWAL, ZAINAB G oth NAWAZ, AHMAD oth SHAH, AMNA oth MURTAZA, GHULAM oth Enthalten in Anais da Academia Brasileira de Ciências Rio de Janeiro, 1929 88(2016), 4, Seite 2303-2317 (DE-627)129938955 (DE-600)391417-3 (DE-576)015500713 0001-3765 nnns volume:88 year:2016 number:4 pages:2303-2317 http://dx.doi.org/10.1590/0001-3765201620160162 Volltext https://doaj.org/article/fbb9927493304462861d9b65003487d4 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-IBA SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_40 GBV_ILN_62 GBV_ILN_156 GBV_ILN_2399 30.00 AVZ AR 88 2016 4 2303-2317
allfieldsSound	10.1590/0001-3765201620160162 doi PQ20170501 (DE-627)OLC1990304788 (DE-599)GBVOLC1990304788 (PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3 (KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm DE-627 ger DE-627 rakwb eng 000 DNB 500 AVZ 30.00 bkl UBAID, MUHAMMAD verfasserin aut Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin. Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science ILYAS, SADAF oth MIR, SADULLAH oth KHAN, ABIDA K oth RASHID, REHANA oth KHAN, MUHAMMAD Z.U oth KANWAL, ZAINAB G oth NAWAZ, AHMAD oth SHAH, AMNA oth MURTAZA, GHULAM oth Enthalten in Anais da Academia Brasileira de Ciências Rio de Janeiro, 1929 88(2016), 4, Seite 2303-2317 (DE-627)129938955 (DE-600)391417-3 (DE-576)015500713 0001-3765 nnns volume:88 year:2016 number:4 pages:2303-2317 http://dx.doi.org/10.1590/0001-3765201620160162 Volltext https://doaj.org/article/fbb9927493304462861d9b65003487d4 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-IBA SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_40 GBV_ILN_62 GBV_ILN_156 GBV_ILN_2399 30.00 AVZ AR 88 2016 4 2303-2317
language	English
source	Enthalten in Anais da Academia Brasileira de Ciências 88(2016), 4, Seite 2303-2317 volume:88 year:2016 number:4 pages:2303-2317
sourceStr	Enthalten in Anais da Academia Brasileira de Ciências 88(2016), 4, Seite 2303-2317 volume:88 year:2016 number:4 pages:2303-2317
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topic_facet	Biology (General) topical gel clotrimazole Central composite design permeability enhancer QH301-705.5 Science
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Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. 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title	Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
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title_full	Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
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title_sort	formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
title_auth	Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
abstract	ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.
abstractGer	ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.
abstract_unstemmed	ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.
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container_issue	4
title_short	Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
url	http://dx.doi.org/10.1590/0001-3765201620160162 https://doaj.org/article/fbb9927493304462861d9b65003487d4
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author2	ILYAS, SADAF MIR, SADULLAH KHAN, ABIDA K RASHID, REHANA KHAN, MUHAMMAD Z.U KANWAL, ZAINAB G NAWAZ, AHMAD SHAH, AMNA MURTAZA, GHULAM
author2Str	ILYAS, SADAF MIR, SADULLAH KHAN, ABIDA K RASHID, REHANA KHAN, MUHAMMAD Z.U KANWAL, ZAINAB G NAWAZ, AHMAD SHAH, AMNA MURTAZA, GHULAM
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up_date	2024-07-04T00:29:18.639Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1990304788</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230510161704.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">170303s2016 xx \|\|\|\|\| 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1590/0001-3765201620160162</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20170501</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1990304788</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1990304788</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1482-88432f865b6e59c3878f03cf7c769f2aa99e0b3eff9210fcd50f30b49bb729da3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0020595820160000088000402303formulationandinvitroevaluationofcarbopol934basedm</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">000</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">500</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">30.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">UBAID, MUHAMMAD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm2/min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm2/min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm2/min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">topical gel</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">clotrimazole</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Central composite design</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">permeability enhancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Science</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">ILYAS, SADAF</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">MIR, SADULLAH</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">KHAN, ABIDA K</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">RASHID, REHANA</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">KHAN, MUHAMMAD Z.U</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">KANWAL, ZAINAB G</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">NAWAZ, AHMAD</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">SHAH, AMNA</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">MURTAZA, GHULAM</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Anais da Academia Brasileira de Ciências</subfield><subfield code="d">Rio de Janeiro, 1929</subfield><subfield code="g">88(2016), 4, Seite 2303-2317</subfield><subfield code="w">(DE-627)129938955</subfield><subfield code="w">(DE-600)391417-3</subfield><subfield code="w">(DE-576)015500713</subfield><subfield code="x">0001-3765</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:88</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:2303-2317</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1590/0001-3765201620160162</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/article/fbb9927493304462861d9b65003487d4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-IBA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_156</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2399</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">30.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">88</subfield><subfield code="j">2016</subfield><subfield code="e">4</subfield><subfield code="h">2303-2317</subfield></datafield></record></collection>
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Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

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