A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography

Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close character...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ingle, Umesh M [verfasserIn] Lali, Arvind M

Format:	Artikel
Sprache:	Englisch

Erschienen:	2017

Rechteinformationen:	Nutzungsrecht: © The Author(s) 2016

Systematik:	VA 1500

Übergeordnetes Werk:	Enthalten in: Adsorption science & technology - London : SAGE Publications Ltd., 1984, 35(2017), 1-2, Seite 102-119
Übergeordnetes Werk:	volume:35 ; year:2017 ; number:1-2 ; pages:102-119

Links:	Volltext Link aufrufen

DOI / URN:	10.1177/0263617416670662

Katalog-ID:	OLC1992890978

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520			\|a Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities.
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allfields	10.1177/0263617416670662 doi PQ20170721 (DE-627)OLC1992890978 (DE-599)GBVOLC1992890978 (PRQ)c1397-b1d588379b58b9b1de527552342f8bce349be4fc7863bae280a174a0c5250b270 (KEY)0120987620170000035000100102rapidpreparativemethodforthepurificationofvitamine DE-627 ger DE-627 rakwb eng 530 660 DE-600 VA 1500 AVZ rvk 33.68 bkl 35.18 bkl 58.13 bkl Ingle, Umesh M verfasserin aut A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities. Nutzungsrecht: © The Author(s) 2016 Lali, Arvind M oth Enthalten in Adsorption science & technology London : SAGE Publications Ltd., 1984 35(2017), 1-2, Seite 102-119 (DE-627)129151424 (DE-600)48745-4 (DE-576)025150405 0263-6174 nnns volume:35 year:2017 number:1-2 pages:102-119 http://dx.doi.org/10.1177/0263617416670662 Volltext http://journals.sagepub.com/doi/full/10.1177/0263617416670662 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2010 VA 1500 33.68 AVZ 35.18 AVZ 58.13 AVZ AR 35 2017 1-2 102-119
spelling	10.1177/0263617416670662 doi PQ20170721 (DE-627)OLC1992890978 (DE-599)GBVOLC1992890978 (PRQ)c1397-b1d588379b58b9b1de527552342f8bce349be4fc7863bae280a174a0c5250b270 (KEY)0120987620170000035000100102rapidpreparativemethodforthepurificationofvitamine DE-627 ger DE-627 rakwb eng 530 660 DE-600 VA 1500 AVZ rvk 33.68 bkl 35.18 bkl 58.13 bkl Ingle, Umesh M verfasserin aut A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities. Nutzungsrecht: © The Author(s) 2016 Lali, Arvind M oth Enthalten in Adsorption science & technology London : SAGE Publications Ltd., 1984 35(2017), 1-2, Seite 102-119 (DE-627)129151424 (DE-600)48745-4 (DE-576)025150405 0263-6174 nnns volume:35 year:2017 number:1-2 pages:102-119 http://dx.doi.org/10.1177/0263617416670662 Volltext http://journals.sagepub.com/doi/full/10.1177/0263617416670662 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2010 VA 1500 33.68 AVZ 35.18 AVZ 58.13 AVZ AR 35 2017 1-2 102-119
allfields_unstemmed	10.1177/0263617416670662 doi PQ20170721 (DE-627)OLC1992890978 (DE-599)GBVOLC1992890978 (PRQ)c1397-b1d588379b58b9b1de527552342f8bce349be4fc7863bae280a174a0c5250b270 (KEY)0120987620170000035000100102rapidpreparativemethodforthepurificationofvitamine DE-627 ger DE-627 rakwb eng 530 660 DE-600 VA 1500 AVZ rvk 33.68 bkl 35.18 bkl 58.13 bkl Ingle, Umesh M verfasserin aut A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities. Nutzungsrecht: © The Author(s) 2016 Lali, Arvind M oth Enthalten in Adsorption science & technology London : SAGE Publications Ltd., 1984 35(2017), 1-2, Seite 102-119 (DE-627)129151424 (DE-600)48745-4 (DE-576)025150405 0263-6174 nnns volume:35 year:2017 number:1-2 pages:102-119 http://dx.doi.org/10.1177/0263617416670662 Volltext http://journals.sagepub.com/doi/full/10.1177/0263617416670662 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_2010 VA 1500 33.68 AVZ 35.18 AVZ 58.13 AVZ AR 35 2017 1-2 102-119
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title	A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography
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title_full	A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography
author_sort	Ingle, Umesh M
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title_sort	rapid preparative method for the purification of vitamin e acetate by kinetic reverse phase chromatography
title_auth	A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography
abstract	Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities.
abstractGer	Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities.
abstract_unstemmed	Alpha-tocopherol or vitamin E is an essential food ingredient. Due to high purity requirement in food applications, it is majorly produced in the acetate form through chemical routes. However, the isolation of food grade vitamin E acetate (VEA) is critical due to the co-generation of close characteristic impurities in the production processes. The work undertaken here provides a new kinetic chromatography method for production of food grade VEA. In this work, suitable adsorbent for chromatography separation was selected based on shallow-bed binding–elution characteristics. Loading conditions were identified by frontal adsorption behavior. Kinetic parameters and bed height for the purification was predicted by establishing the relationship between bed height, purity and the relative separation factor (RSF). The RSF of 2.8 and corresponding bed height is predicted from the established relationship for the separation of VEA from impurities. The bed height of 170 cm with isocratic mobile phase of 2% (wt/wt) water in methanol provides 98 wt.% purity of VEA with recovery of 90%. This work has highlighted methodology based on kinetic parameters for the separation of close characteristic impurities from target molecule. This work also provided the application of simple handy tools like RSF and dual wavelength detection for the rapid development of preparative separation process for VEA and other such valuable components from unknown impurities.
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title_short	A rapid preparative method for the purification of vitamin E acetate by kinetic reverse phase chromatography
url	http://dx.doi.org/10.1177/0263617416670662 http://journals.sagepub.com/doi/full/10.1177/0263617416670662
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up_date	2024-07-04T05:53:12.161Z
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