Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans
BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effect...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kudelska, Monika M [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Rechteinformationen: |
Nutzungsrecht: © 2017 Society of Chemical Industry |
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| Schlagwörter: |
nicotinic acetylcholine receptors |
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| Übergeordnetes Werk: |
Enthalten in: Pest management science - Chichester : Wiley, 2000, 73(2017), 7, Seite 1345-1351 |
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| Übergeordnetes Werk: |
volume:73 ; year:2017 ; number:7 ; pages:1345-1351 |
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| DOI / URN: |
10.1002/ps.4564 |
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| 245 | 1 | 0 | |a Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans |
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| 520 | |a BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry | ||
| 540 | |a Nutzungsrecht: © 2017 Society of Chemical Industry | ||
| 650 | 4 | |a nicotine | |
| 650 | 4 | |a bus‐17 | |
| 650 | 4 | |a thiacloprid | |
| 650 | 4 | |a nicotinic acetylcholine receptors | |
| 650 | 4 | |a toxicity | |
| 650 | 4 | |a Sensitivity | |
| 650 | 4 | |a Agricultural chemicals | |
| 650 | 4 | |a Ecological effects | |
| 650 | 4 | |a Ecosystems | |
| 650 | 4 | |a Worms | |
| 650 | 4 | |a Receptors | |
| 650 | 4 | |a Toxicity | |
| 650 | 4 | |a Biomass | |
| 650 | 4 | |a Cuticle | |
| 650 | 4 | |a Larval development | |
| 650 | 4 | |a Beneficial arthropods | |
| 650 | 4 | |a Insects | |
| 650 | 4 | |a Thiacloprid | |
| 650 | 4 | |a Acetylcholine receptors (nicotinic) | |
| 650 | 4 | |a Assaying | |
| 650 | 4 | |a Permeability | |
| 650 | 4 | |a Insecticides | |
| 650 | 4 | |a Biological effects | |
| 650 | 4 | |a Pollinators | |
| 650 | 4 | |a Exposure | |
| 650 | 4 | |a Pesticides | |
| 650 | 4 | |a Transgenic | |
| 650 | 4 | |a Nematodes | |
| 700 | 1 | |a Holden‐Dye, Lindy |4 oth | |
| 700 | 1 | |a O'Connor, Vincent |4 oth | |
| 700 | 1 | |a Doyle, Declan A |4 oth | |
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10.1002/ps.4564 doi PQ20171228 (DE-627)OLC199411634X (DE-599)GBVOLC199411634X (PRQ)p1584-d5702a32f7f12d48471367f74017bd01ce39777e2a3e618c20d11bc852c4a5893 (KEY)0016093820170000073000701345concentrationdependenteffectsofacuteandchronicneon DE-627 ger DE-627 rakwb eng 570 580 630 640 660 DNB 48.54 bkl Kudelska, Monika M verfasserin aut Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry Nutzungsrecht: © 2017 Society of Chemical Industry nicotine bus‐17 thiacloprid nicotinic acetylcholine receptors toxicity Sensitivity Agricultural chemicals Ecological effects Ecosystems Worms Receptors Toxicity Biomass Cuticle Larval development Beneficial arthropods Insects Thiacloprid Acetylcholine receptors (nicotinic) Assaying Permeability Insecticides Biological effects Pollinators Exposure Pesticides Transgenic Nematodes Holden‐Dye, Lindy oth O'Connor, Vincent oth Doyle, Declan A oth Enthalten in Pest management science Chichester : Wiley, 2000 73(2017), 7, Seite 1345-1351 (DE-627)309622565 (DE-600)2001705-4 (DE-576)084508841 1526-498X nnns volume:73 year:2017 number:7 pages:1345-1351 http://dx.doi.org/10.1002/ps.4564 Volltext http://onlinelibrary.wiley.com/doi/10.1002/ps.4564/abstract https://search.proquest.com/docview/1906838373 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_4219 48.54 AVZ AR 73 2017 7 1345-1351 |
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10.1002/ps.4564 doi PQ20171228 (DE-627)OLC199411634X (DE-599)GBVOLC199411634X (PRQ)p1584-d5702a32f7f12d48471367f74017bd01ce39777e2a3e618c20d11bc852c4a5893 (KEY)0016093820170000073000701345concentrationdependenteffectsofacuteandchronicneon DE-627 ger DE-627 rakwb eng 570 580 630 640 660 DNB 48.54 bkl Kudelska, Monika M verfasserin aut Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry Nutzungsrecht: © 2017 Society of Chemical Industry nicotine bus‐17 thiacloprid nicotinic acetylcholine receptors toxicity Sensitivity Agricultural chemicals Ecological effects Ecosystems Worms Receptors Toxicity Biomass Cuticle Larval development Beneficial arthropods Insects Thiacloprid Acetylcholine receptors (nicotinic) Assaying Permeability Insecticides Biological effects Pollinators Exposure Pesticides Transgenic Nematodes Holden‐Dye, Lindy oth O'Connor, Vincent oth Doyle, Declan A oth Enthalten in Pest management science Chichester : Wiley, 2000 73(2017), 7, Seite 1345-1351 (DE-627)309622565 (DE-600)2001705-4 (DE-576)084508841 1526-498X nnns volume:73 year:2017 number:7 pages:1345-1351 http://dx.doi.org/10.1002/ps.4564 Volltext http://onlinelibrary.wiley.com/doi/10.1002/ps.4564/abstract https://search.proquest.com/docview/1906838373 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_4219 48.54 AVZ AR 73 2017 7 1345-1351 |
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10.1002/ps.4564 doi PQ20171228 (DE-627)OLC199411634X (DE-599)GBVOLC199411634X (PRQ)p1584-d5702a32f7f12d48471367f74017bd01ce39777e2a3e618c20d11bc852c4a5893 (KEY)0016093820170000073000701345concentrationdependenteffectsofacuteandchronicneon DE-627 ger DE-627 rakwb eng 570 580 630 640 660 DNB 48.54 bkl Kudelska, Monika M verfasserin aut Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry Nutzungsrecht: © 2017 Society of Chemical Industry nicotine bus‐17 thiacloprid nicotinic acetylcholine receptors toxicity Sensitivity Agricultural chemicals Ecological effects Ecosystems Worms Receptors Toxicity Biomass Cuticle Larval development Beneficial arthropods Insects Thiacloprid Acetylcholine receptors (nicotinic) Assaying Permeability Insecticides Biological effects Pollinators Exposure Pesticides Transgenic Nematodes Holden‐Dye, Lindy oth O'Connor, Vincent oth Doyle, Declan A oth Enthalten in Pest management science Chichester : Wiley, 2000 73(2017), 7, Seite 1345-1351 (DE-627)309622565 (DE-600)2001705-4 (DE-576)084508841 1526-498X nnns volume:73 year:2017 number:7 pages:1345-1351 http://dx.doi.org/10.1002/ps.4564 Volltext http://onlinelibrary.wiley.com/doi/10.1002/ps.4564/abstract https://search.proquest.com/docview/1906838373 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_4219 48.54 AVZ AR 73 2017 7 1345-1351 |
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10.1002/ps.4564 doi PQ20171228 (DE-627)OLC199411634X (DE-599)GBVOLC199411634X (PRQ)p1584-d5702a32f7f12d48471367f74017bd01ce39777e2a3e618c20d11bc852c4a5893 (KEY)0016093820170000073000701345concentrationdependenteffectsofacuteandchronicneon DE-627 ger DE-627 rakwb eng 570 580 630 640 660 DNB 48.54 bkl Kudelska, Monika M verfasserin aut Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry Nutzungsrecht: © 2017 Society of Chemical Industry nicotine bus‐17 thiacloprid nicotinic acetylcholine receptors toxicity Sensitivity Agricultural chemicals Ecological effects Ecosystems Worms Receptors Toxicity Biomass Cuticle Larval development Beneficial arthropods Insects Thiacloprid Acetylcholine receptors (nicotinic) Assaying Permeability Insecticides Biological effects Pollinators Exposure Pesticides Transgenic Nematodes Holden‐Dye, Lindy oth O'Connor, Vincent oth Doyle, Declan A oth Enthalten in Pest management science Chichester : Wiley, 2000 73(2017), 7, Seite 1345-1351 (DE-627)309622565 (DE-600)2001705-4 (DE-576)084508841 1526-498X nnns volume:73 year:2017 number:7 pages:1345-1351 http://dx.doi.org/10.1002/ps.4564 Volltext http://onlinelibrary.wiley.com/doi/10.1002/ps.4564/abstract https://search.proquest.com/docview/1906838373 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_4219 48.54 AVZ AR 73 2017 7 1345-1351 |
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10.1002/ps.4564 doi PQ20171228 (DE-627)OLC199411634X (DE-599)GBVOLC199411634X (PRQ)p1584-d5702a32f7f12d48471367f74017bd01ce39777e2a3e618c20d11bc852c4a5893 (KEY)0016093820170000073000701345concentrationdependenteffectsofacuteandchronicneon DE-627 ger DE-627 rakwb eng 570 580 630 640 660 DNB 48.54 bkl Kudelska, Monika M verfasserin aut Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry Nutzungsrecht: © 2017 Society of Chemical Industry nicotine bus‐17 thiacloprid nicotinic acetylcholine receptors toxicity Sensitivity Agricultural chemicals Ecological effects Ecosystems Worms Receptors Toxicity Biomass Cuticle Larval development Beneficial arthropods Insects Thiacloprid Acetylcholine receptors (nicotinic) Assaying Permeability Insecticides Biological effects Pollinators Exposure Pesticides Transgenic Nematodes Holden‐Dye, Lindy oth O'Connor, Vincent oth Doyle, Declan A oth Enthalten in Pest management science Chichester : Wiley, 2000 73(2017), 7, Seite 1345-1351 (DE-627)309622565 (DE-600)2001705-4 (DE-576)084508841 1526-498X nnns volume:73 year:2017 number:7 pages:1345-1351 http://dx.doi.org/10.1002/ps.4564 Volltext http://onlinelibrary.wiley.com/doi/10.1002/ps.4564/abstract https://search.proquest.com/docview/1906838373 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_4219 48.54 AVZ AR 73 2017 7 1345-1351 |
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Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. 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concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode caenorhabditis elegans |
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Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans |
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BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry |
| abstractGer |
BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry |
| abstract_unstemmed |
BACKGROUND Neonicotinoid insecticides are under review owing to emerging toxicity to non-target species. Interest has focused on biological pollinators while their effects on other organisms that are key contributors to the ecosystem remain largely unknown. To advance this, we have tested the effects of representatives of three major classes of neonicotinoids, thiacloprid, clothianidin and nitenpyram, on the free-living nematode Caenorhabditis elegans (C. elegans), as a representative of the Nematoda, an ecologically important phylum contributing to biomass. RESULTS Concentrations that are several-fold higher than those with effects against target species had limited impact on locomotor function. However, increased potency was observed in a mutant with a hyperpermeable cuticle, which shows that drug access limits the effects of the neonicotinoids in C. elegans. Thiacloprid was most potent (EC50 714 µm). In addition, it selectively delayed larval development in wild-type worms at 1 mm. CONCLUSION C. elegans is less susceptible to neonicotinoids than target species of pest insect. We discuss an approach in which this defined low sensitivity may be exploited by heterologous expression of insect nicotinic acetylcholine receptors from both pest and beneficial insects in transgenic C. elegans with increased cuticle permeability to provide a whole organism assay for species-dependent neonicotinoid effects. © 2017 Society of Chemical Industry |
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Concentration‐dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans |
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