Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K
Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol...
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| Autor*in: |
Martínez, Fleming [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Rechteinformationen: |
Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Physics and chemistry of liquids - New York, NY, 1968, 55(2017), 3, Seite 291-303 |
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| Übergeordnetes Werk: |
volume:55 ; year:2017 ; number:3 ; pages:291-303 |
| Links: |
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| DOI / URN: |
10.1080/00319104.2016.1198481 |
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| 520 | |a Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. | ||
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10.1080/00319104.2016.1198481 doi PQ20170721 (DE-627)OLC1994465018 (DE-599)GBVOLC1994465018 (PRQ)c2128-503d3dd6792f4e78c7db860ed3b3e8dae9ddb276e888a7109e75ae026d2d958c0 (KEY)0054193120170000055000300291preferentialsolvationofetoricoxibinsomeaqueousbina DE-627 ger DE-627 rakwb eng 530 540 DNB 33.69 bkl 35.21 bkl Martínez, Fleming verfasserin aut Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 inverse Kirkwood-Buff integrals preferential solvation Etoricoxib binary cosolvent mixtures Jouyban, Abolghasem oth Acree, William E oth Enthalten in Physics and chemistry of liquids New York, NY, 1968 55(2017), 3, Seite 291-303 (DE-627)129083267 (DE-600)3900-7 (DE-576)014416522 0031-9104 nnns volume:55 year:2017 number:3 pages:291-303 http://dx.doi.org/10.1080/00319104.2016.1198481 Volltext http://www.tandfonline.com/doi/abs/10.1080/00319104.2016.1198481 https://search.proquest.com/docview/1859441343 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 33.69 AVZ 35.21 AVZ AR 55 2017 3 291-303 |
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10.1080/00319104.2016.1198481 doi PQ20170721 (DE-627)OLC1994465018 (DE-599)GBVOLC1994465018 (PRQ)c2128-503d3dd6792f4e78c7db860ed3b3e8dae9ddb276e888a7109e75ae026d2d958c0 (KEY)0054193120170000055000300291preferentialsolvationofetoricoxibinsomeaqueousbina DE-627 ger DE-627 rakwb eng 530 540 DNB 33.69 bkl 35.21 bkl Martínez, Fleming verfasserin aut Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 inverse Kirkwood-Buff integrals preferential solvation Etoricoxib binary cosolvent mixtures Jouyban, Abolghasem oth Acree, William E oth Enthalten in Physics and chemistry of liquids New York, NY, 1968 55(2017), 3, Seite 291-303 (DE-627)129083267 (DE-600)3900-7 (DE-576)014416522 0031-9104 nnns volume:55 year:2017 number:3 pages:291-303 http://dx.doi.org/10.1080/00319104.2016.1198481 Volltext http://www.tandfonline.com/doi/abs/10.1080/00319104.2016.1198481 https://search.proquest.com/docview/1859441343 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 33.69 AVZ 35.21 AVZ AR 55 2017 3 291-303 |
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10.1080/00319104.2016.1198481 doi PQ20170721 (DE-627)OLC1994465018 (DE-599)GBVOLC1994465018 (PRQ)c2128-503d3dd6792f4e78c7db860ed3b3e8dae9ddb276e888a7109e75ae026d2d958c0 (KEY)0054193120170000055000300291preferentialsolvationofetoricoxibinsomeaqueousbina DE-627 ger DE-627 rakwb eng 530 540 DNB 33.69 bkl 35.21 bkl Martínez, Fleming verfasserin aut Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 inverse Kirkwood-Buff integrals preferential solvation Etoricoxib binary cosolvent mixtures Jouyban, Abolghasem oth Acree, William E oth Enthalten in Physics and chemistry of liquids New York, NY, 1968 55(2017), 3, Seite 291-303 (DE-627)129083267 (DE-600)3900-7 (DE-576)014416522 0031-9104 nnns volume:55 year:2017 number:3 pages:291-303 http://dx.doi.org/10.1080/00319104.2016.1198481 Volltext http://www.tandfonline.com/doi/abs/10.1080/00319104.2016.1198481 https://search.proquest.com/docview/1859441343 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 33.69 AVZ 35.21 AVZ AR 55 2017 3 291-303 |
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10.1080/00319104.2016.1198481 doi PQ20170721 (DE-627)OLC1994465018 (DE-599)GBVOLC1994465018 (PRQ)c2128-503d3dd6792f4e78c7db860ed3b3e8dae9ddb276e888a7109e75ae026d2d958c0 (KEY)0054193120170000055000300291preferentialsolvationofetoricoxibinsomeaqueousbina DE-627 ger DE-627 rakwb eng 530 540 DNB 33.69 bkl 35.21 bkl Martínez, Fleming verfasserin aut Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 inverse Kirkwood-Buff integrals preferential solvation Etoricoxib binary cosolvent mixtures Jouyban, Abolghasem oth Acree, William E oth Enthalten in Physics and chemistry of liquids New York, NY, 1968 55(2017), 3, Seite 291-303 (DE-627)129083267 (DE-600)3900-7 (DE-576)014416522 0031-9104 nnns volume:55 year:2017 number:3 pages:291-303 http://dx.doi.org/10.1080/00319104.2016.1198481 Volltext http://www.tandfonline.com/doi/abs/10.1080/00319104.2016.1198481 https://search.proquest.com/docview/1859441343 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 33.69 AVZ 35.21 AVZ AR 55 2017 3 291-303 |
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10.1080/00319104.2016.1198481 doi PQ20170721 (DE-627)OLC1994465018 (DE-599)GBVOLC1994465018 (PRQ)c2128-503d3dd6792f4e78c7db860ed3b3e8dae9ddb276e888a7109e75ae026d2d958c0 (KEY)0054193120170000055000300291preferentialsolvationofetoricoxibinsomeaqueousbina DE-627 ger DE-627 rakwb eng 530 540 DNB 33.69 bkl 35.21 bkl Martínez, Fleming verfasserin aut Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. Nutzungsrecht: © 2016 Informa UK Limited, trading as Taylor & Francis Group 2016 inverse Kirkwood-Buff integrals preferential solvation Etoricoxib binary cosolvent mixtures Jouyban, Abolghasem oth Acree, William E oth Enthalten in Physics and chemistry of liquids New York, NY, 1968 55(2017), 3, Seite 291-303 (DE-627)129083267 (DE-600)3900-7 (DE-576)014416522 0031-9104 nnns volume:55 year:2017 number:3 pages:291-303 http://dx.doi.org/10.1080/00319104.2016.1198481 Volltext http://www.tandfonline.com/doi/abs/10.1080/00319104.2016.1198481 https://search.proquest.com/docview/1859441343 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 33.69 AVZ 35.21 AVZ AR 55 2017 3 291-303 |
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preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 k |
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Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K |
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Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. |
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Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. |
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Preferential solvation parameters of etoricoxib in several aqueous cosolvent mixtures were calculated from solubilities and other thermodynamic properties by using the IKBI method. Cosolvents studied were as follows: 1,4-dioxane, N,N-dimethylacetamide, 1,4-butanediol, N,N-dimethylformamide, ethanol and dimethyl sulfoxide. Etoricoxib exhibits solvation effects, being the preferential solvation parameter δx 1,3 , negative in water-rich and cosolvent-rich mixtures but positive in mixtures with similar proportions of both solvents. It is conjecturable that the hydrophobic hydration in water-rich mixtures plays a relevant role in drug solvation. In mixtures of similar solvent proportions where etoricoxib is preferentially solvated by the cosolvents, the drug could be acting as Lewis acid with the more basic cosolvents. Finally, in cosolvent-rich mixtures the preferential solvation by water could be due to the more acidic behaviour of water. Nevertheless, the specific solute-solvent interactions in the different binary systems remain unclear because no relation between preferential solvation magnitude and cosolvent polarities has been observed. |
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Preferential solvation of etoricoxib in some aqueous binary cosolvent mixtures at 298.15 K |
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