Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles

Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leadi...
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Autor*in:	Amadei, Elizabeth A [verfasserIn] Johnson, Zachary V Jun Kwon, Yong Shpiner, Aaron C Saravanan, Varun Mays, Wittney D Ryan, Steven J Walum, Hasse Rainnie, Donald G Young, Larry J Liu, Robert C

Format:	Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal)

Übergeordnetes Werk:	Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 546(2017), 7657, Seite 297
Übergeordnetes Werk:	volume:546 ; year:2017 ; number:7657 ; pages:297

Links:	Volltext Link aufrufen

DOI / URN:	10.1038/nature22381

Katalog-ID:	OLC199462728X

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spelling	10.1038/nature22381 doi PQ20171125 (DE-627)OLC199462728X (DE-599)GBVOLC199462728X (PRQ)g1469-7ef53391ec35c4eb19457b90cb44e22dcd76d01fd009c4fcc2fc8fb8f691428a0 (KEY)0072945020170000546765700297dynamiccorticostriatalactivitybiasessocialbondingi DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Amadei, Elizabeth A verfasserin aut Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour. Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal) Johnson, Zachary V oth Jun Kwon, Yong oth Shpiner, Aaron C oth Saravanan, Varun oth Mays, Wittney D oth Ryan, Steven J oth Walum, Hasse oth Rainnie, Donald G oth Young, Larry J oth Liu, Robert C oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 297 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:297 http://dx.doi.org/10.1038/nature22381 Volltext https://search.proquest.com/docview/1909738622 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 297
allfields_unstemmed	10.1038/nature22381 doi PQ20171125 (DE-627)OLC199462728X (DE-599)GBVOLC199462728X (PRQ)g1469-7ef53391ec35c4eb19457b90cb44e22dcd76d01fd009c4fcc2fc8fb8f691428a0 (KEY)0072945020170000546765700297dynamiccorticostriatalactivitybiasessocialbondingi DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Amadei, Elizabeth A verfasserin aut Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour. Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal) Johnson, Zachary V oth Jun Kwon, Yong oth Shpiner, Aaron C oth Saravanan, Varun oth Mays, Wittney D oth Ryan, Steven J oth Walum, Hasse oth Rainnie, Donald G oth Young, Larry J oth Liu, Robert C oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 297 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:297 http://dx.doi.org/10.1038/nature22381 Volltext https://search.proquest.com/docview/1909738622 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 297
allfieldsGer	10.1038/nature22381 doi PQ20171125 (DE-627)OLC199462728X (DE-599)GBVOLC199462728X (PRQ)g1469-7ef53391ec35c4eb19457b90cb44e22dcd76d01fd009c4fcc2fc8fb8f691428a0 (KEY)0072945020170000546765700297dynamiccorticostriatalactivitybiasessocialbondingi DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Amadei, Elizabeth A verfasserin aut Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour. Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal) Johnson, Zachary V oth Jun Kwon, Yong oth Shpiner, Aaron C oth Saravanan, Varun oth Mays, Wittney D oth Ryan, Steven J oth Walum, Hasse oth Rainnie, Donald G oth Young, Larry J oth Liu, Robert C oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 297 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:297 http://dx.doi.org/10.1038/nature22381 Volltext https://search.proquest.com/docview/1909738622 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 297
allfieldsSound	10.1038/nature22381 doi PQ20171125 (DE-627)OLC199462728X (DE-599)GBVOLC199462728X (PRQ)g1469-7ef53391ec35c4eb19457b90cb44e22dcd76d01fd009c4fcc2fc8fb8f691428a0 (KEY)0072945020170000546765700297dynamiccorticostriatalactivitybiasessocialbondingi DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Amadei, Elizabeth A verfasserin aut Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour. Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal) Johnson, Zachary V oth Jun Kwon, Yong oth Shpiner, Aaron C oth Saravanan, Varun oth Mays, Wittney D oth Ryan, Steven J oth Walum, Hasse oth Rainnie, Donald G oth Young, Larry J oth Liu, Robert C oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 297 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:297 http://dx.doi.org/10.1038/nature22381 Volltext https://search.proquest.com/docview/1909738622 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 297
language	English
source	Enthalten in Nature 546(2017), 7657, Seite 297 volume:546 year:2017 number:7657 pages:297
sourceStr	Enthalten in Nature 546(2017), 7657, Seite 297 volume:546 year:2017 number:7657 pages:297
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal)
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isfreeaccess_bool	false
container_title	Nature
authorswithroles_txt_mv	Amadei, Elizabeth A @@aut@@ Johnson, Zachary V @@oth@@ Jun Kwon, Yong @@oth@@ Shpiner, Aaron C @@oth@@ Saravanan, Varun @@oth@@ Mays, Wittney D @@oth@@ Ryan, Steven J @@oth@@ Walum, Hasse @@oth@@ Rainnie, Donald G @@oth@@ Young, Larry J @@oth@@ Liu, Robert C @@oth@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	129292834
dewey-sort	270
id	OLC199462728X
language_de	englisch
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author	Amadei, Elizabeth A
spellingShingle	Amadei, Elizabeth A ddc 070 ddc 500 fid BIODIV misc Corpus striatum misc Social aspects misc Research misc Social behavior in animals misc Prairie vole misc Psychological aspects misc Animals misc Huddling misc Animal cognition misc Correlation misc Mating misc Cortex misc Bonding misc Dynamical systems misc Reinforcement misc Nuclei misc Animal behavior misc Rodents misc Nucleus accumbens misc Mathematical models misc Neural networks misc Recruitment misc Brain misc Circuits misc Functional anatomy misc Social interactions misc Strength misc Perception misc Social behavior misc Females misc Cortex (prefrontal) Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
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topic_title	070 500 DE-101 500 AVZ BIODIV fid Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles Corpus striatum Social aspects Research Social behavior in animals Prairie vole Psychological aspects Animals Huddling Animal cognition Correlation Mating Cortex Bonding Dynamical systems Reinforcement Nuclei Animal behavior Rodents Nucleus accumbens Mathematical models Neural networks Recruitment Brain Circuits Functional anatomy Social interactions Strength Perception Social behavior Females Cortex (prefrontal)
topic	ddc 070 ddc 500 fid BIODIV misc Corpus striatum misc Social aspects misc Research misc Social behavior in animals misc Prairie vole misc Psychological aspects misc Animals misc Huddling misc Animal cognition misc Correlation misc Mating misc Cortex misc Bonding misc Dynamical systems misc Reinforcement misc Nuclei misc Animal behavior misc Rodents misc Nucleus accumbens misc Mathematical models misc Neural networks misc Recruitment misc Brain misc Circuits misc Functional anatomy misc Social interactions misc Strength misc Perception misc Social behavior misc Females misc Cortex (prefrontal)
topic_unstemmed	ddc 070 ddc 500 fid BIODIV misc Corpus striatum misc Social aspects misc Research misc Social behavior in animals misc Prairie vole misc Psychological aspects misc Animals misc Huddling misc Animal cognition misc Correlation misc Mating misc Cortex misc Bonding misc Dynamical systems misc Reinforcement misc Nuclei misc Animal behavior misc Rodents misc Nucleus accumbens misc Mathematical models misc Neural networks misc Recruitment misc Brain misc Circuits misc Functional anatomy misc Social interactions misc Strength misc Perception misc Social behavior misc Females misc Cortex (prefrontal)
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title	Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
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title_full	Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
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title_sort	dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
title_auth	Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
abstract	Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour.
abstractGer	Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour.
abstract_unstemmed	Adult pair bonding involves dramatic changes in the perception and valuation of another individual1. One key change is that partners come to reliably activate the brain’s reward system2-6, although the precise neural mechanisms by which partners become rewarding during sociosexual interactions leading to a bond remain unclear. Here we show, using a prairie vole (Microtus ochrogaster) model of social bonding7, how a functional circuit from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner. Individual variation in the strength of this functional connectivity, particularly after the first mating encounter, predicts how quickly animals begin affiliative huddling with their partner. Rhythmically activating this circuit in a social context without mating biases later preference towards a partner, indicating that this circuit’s activity is not just correlated with how quickly animals become affiliative but causally accelerates it. These results provide the first dynamic view of corticostriatal activity during bond formation, revealing how social interactions can recruit brain reward systems to drive changes in affiliative behaviour.
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container_issue	7657
title_short	Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
url	http://dx.doi.org/10.1038/nature22381 https://search.proquest.com/docview/1909738622
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author2	Johnson, Zachary V Jun Kwon, Yong Shpiner, Aaron C Saravanan, Varun Mays, Wittney D Ryan, Steven J Walum, Hasse Rainnie, Donald G Young, Larry J Liu, Robert C
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up_date	2024-07-03T18:37:07.895Z
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