Nutrient acquisition strategies of mammalian cells

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Palm, Wilhelm [verfasserIn] Thompson, Craig B

Format:	Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism

Übergeordnetes Werk:	Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 546(2017), 7657, Seite 234
Übergeordnetes Werk:	volume:546 ; year:2017 ; number:7657 ; pages:234

Links:	Volltext Link aufrufen

DOI / URN:	10.1038/nature22379

Katalog-ID:	OLC199462731X

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520			\|a Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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650		4	\|a Micronutrients
650		4	\|a Nutrient uptake
650		4	\|a Starvation
650		4	\|a Amino acids
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allfields	10.1038/nature22379 doi PQ20171125 (DE-627)OLC199462731X (DE-599)GBVOLC199462731X (PRQ)g1467-e697a9e1104a370f79e02558ecbf7775c164da547bb00c498b3be1c1c336f0fc0 (KEY)0072945020170000546765700234nutrientacquisitionstrategiesofmammaliancells DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Palm, Wilhelm verfasserin aut Nutrient acquisition strategies of mammalian cells 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells. Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism Thompson, Craig B oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 234 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:234 http://dx.doi.org/10.1038/nature22379 Volltext https://search.proquest.com/docview/1909738427 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 234
spelling	10.1038/nature22379 doi PQ20171125 (DE-627)OLC199462731X (DE-599)GBVOLC199462731X (PRQ)g1467-e697a9e1104a370f79e02558ecbf7775c164da547bb00c498b3be1c1c336f0fc0 (KEY)0072945020170000546765700234nutrientacquisitionstrategiesofmammaliancells DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Palm, Wilhelm verfasserin aut Nutrient acquisition strategies of mammalian cells 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells. Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism Thompson, Craig B oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 234 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:234 http://dx.doi.org/10.1038/nature22379 Volltext https://search.proquest.com/docview/1909738427 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 234
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allfieldsGer	10.1038/nature22379 doi PQ20171125 (DE-627)OLC199462731X (DE-599)GBVOLC199462731X (PRQ)g1467-e697a9e1104a370f79e02558ecbf7775c164da547bb00c498b3be1c1c336f0fc0 (KEY)0072945020170000546765700234nutrientacquisitionstrategiesofmammaliancells DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Palm, Wilhelm verfasserin aut Nutrient acquisition strategies of mammalian cells 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells. Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism Thompson, Craig B oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 234 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:234 http://dx.doi.org/10.1038/nature22379 Volltext https://search.proquest.com/docview/1909738427 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 234
allfieldsSound	10.1038/nature22379 doi PQ20171125 (DE-627)OLC199462731X (DE-599)GBVOLC199462731X (PRQ)g1467-e697a9e1104a370f79e02558ecbf7775c164da547bb00c498b3be1c1c336f0fc0 (KEY)0072945020170000546765700234nutrientacquisitionstrategiesofmammaliancells DE-627 ger DE-627 rakwb eng 070 500 DE-101 500 AVZ BIODIV fid Palm, Wilhelm verfasserin aut Nutrient acquisition strategies of mammalian cells 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells. Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism Thompson, Craig B oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 546(2017), 7657, Seite 234 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:546 year:2017 number:7657 pages:234 http://dx.doi.org/10.1038/nature22379 Volltext https://search.proquest.com/docview/1909738427 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_135 GBV_ILN_154 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 AR 546 2017 7657 234
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topic_facet	Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism
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author	Palm, Wilhelm
spellingShingle	Palm, Wilhelm ddc 070 ddc 500 fid BIODIV misc Cell metabolism misc Research misc Cell research misc Cell survival misc Macromolecules misc Sensors misc Mammals misc Cells misc Flexibility misc Glucose misc Survival misc Metabolites misc Nutrients misc Homeostasis misc Control misc Mammalian cells misc Growth factors misc Micronutrients misc Nutrient uptake misc Starvation misc Amino acids misc Pathways misc Medical research misc Tumors misc Cell growth misc Biomass misc Cancer misc Suppressors misc Reviews misc Nutrient sources misc Metabolism Nutrient acquisition strategies of mammalian cells
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topic_title	070 500 DE-101 500 AVZ BIODIV fid Nutrient acquisition strategies of mammalian cells Cell metabolism Research Cell research Cell survival Macromolecules Sensors Mammals Cells Flexibility Glucose Survival Metabolites Nutrients Homeostasis Control Mammalian cells Growth factors Micronutrients Nutrient uptake Starvation Amino acids Pathways Medical research Tumors Cell growth Biomass Cancer Suppressors Reviews Nutrient sources Metabolism
topic	ddc 070 ddc 500 fid BIODIV misc Cell metabolism misc Research misc Cell research misc Cell survival misc Macromolecules misc Sensors misc Mammals misc Cells misc Flexibility misc Glucose misc Survival misc Metabolites misc Nutrients misc Homeostasis misc Control misc Mammalian cells misc Growth factors misc Micronutrients misc Nutrient uptake misc Starvation misc Amino acids misc Pathways misc Medical research misc Tumors misc Cell growth misc Biomass misc Cancer misc Suppressors misc Reviews misc Nutrient sources misc Metabolism
topic_unstemmed	ddc 070 ddc 500 fid BIODIV misc Cell metabolism misc Research misc Cell research misc Cell survival misc Macromolecules misc Sensors misc Mammals misc Cells misc Flexibility misc Glucose misc Survival misc Metabolites misc Nutrients misc Homeostasis misc Control misc Mammalian cells misc Growth factors misc Micronutrients misc Nutrient uptake misc Starvation misc Amino acids misc Pathways misc Medical research misc Tumors misc Cell growth misc Biomass misc Cancer misc Suppressors misc Reviews misc Nutrient sources misc Metabolism
topic_browse	ddc 070 ddc 500 fid BIODIV misc Cell metabolism misc Research misc Cell research misc Cell survival misc Macromolecules misc Sensors misc Mammals misc Cells misc Flexibility misc Glucose misc Survival misc Metabolites misc Nutrients misc Homeostasis misc Control misc Mammalian cells misc Growth factors misc Micronutrients misc Nutrient uptake misc Starvation misc Amino acids misc Pathways misc Medical research misc Tumors misc Cell growth misc Biomass misc Cancer misc Suppressors misc Reviews misc Nutrient sources misc Metabolism
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title	Nutrient acquisition strategies of mammalian cells
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title_full	Nutrient acquisition strategies of mammalian cells
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title_sort	nutrient acquisition strategies of mammalian cells
title_auth	Nutrient acquisition strategies of mammalian cells
abstract	Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
abstractGer	Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
abstract_unstemmed	Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth - factor - induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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title_short	Nutrient acquisition strategies of mammalian cells
url	http://dx.doi.org/10.1038/nature22379 https://search.proquest.com/docview/1909738427
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up_date	2024-07-03T18:37:08.198Z
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Nutrient acquisition strategies of mammalian cells

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