Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study
In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studie...
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| Autor*in: |
Baron, Cécile [verfasserIn] |
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| Format: |
Artikel |
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| Erschienen: |
2017 |
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| Rechteinformationen: |
Nutzungsrecht: © Acoustical Society of America |
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| Systematik: |
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| Übergeordnetes Werk: |
Enthalten in: The journal of the Acoustical Society of America - Melville, NY : AIP, 1929, 142(2017), 4, Seite 2600-2600 |
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| Übergeordnetes Werk: |
volume:142 ; year:2017 ; number:4 ; pages:2600-2600 |
| Links: |
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| DOI / URN: |
10.1121/1.5014516 |
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| 520 | |a In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. | ||
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10.1121/1.5014516 doi PQ20171228 (DE-627)OLC1997723220 (DE-599)GBVOLC1997723220 (PRQ)scitation_primary_10_1121_1_50145160 (KEY)0112299120170000142000402600bonerepairandultrasoundstimulationaninsightintothe DE-627 ger DE-627 rakwb 530 DE-600 LING fid EQ 1000: AVZ rvk 33.12 bkl 50.36 bkl Baron, Cécile verfasserin aut Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. Nutzungsrecht: © Acoustical Society of America Guivier-Curien, Carine oth Nguyen, Vu-Hieu oth Naili, Salah oth Enthalten in The journal of the Acoustical Society of America Melville, NY : AIP, 1929 142(2017), 4, Seite 2600-2600 (DE-627)129550264 (DE-600)219231-7 (DE-576)015003663 0001-4966 nnns volume:142 year:2017 number:4 pages:2600-2600 http://dx.doi.org/10.1121/1.5014516 Volltext http://dx.doi.org/10.1121/1.5014516 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-MUS GBV_ILN_59 GBV_ILN_60 GBV_ILN_70 GBV_ILN_120 GBV_ILN_170 GBV_ILN_201 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2027 GBV_ILN_2045 GBV_ILN_2192 GBV_ILN_2256 GBV_ILN_4219 GBV_ILN_4315 GBV_ILN_4319 GBV_ILN_4700 EQ 1000: 33.12 AVZ 50.36 AVZ AR 142 2017 4 2600-2600 |
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10.1121/1.5014516 doi PQ20171228 (DE-627)OLC1997723220 (DE-599)GBVOLC1997723220 (PRQ)scitation_primary_10_1121_1_50145160 (KEY)0112299120170000142000402600bonerepairandultrasoundstimulationaninsightintothe DE-627 ger DE-627 rakwb 530 DE-600 LING fid EQ 1000: AVZ rvk 33.12 bkl 50.36 bkl Baron, Cécile verfasserin aut Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. Nutzungsrecht: © Acoustical Society of America Guivier-Curien, Carine oth Nguyen, Vu-Hieu oth Naili, Salah oth Enthalten in The journal of the Acoustical Society of America Melville, NY : AIP, 1929 142(2017), 4, Seite 2600-2600 (DE-627)129550264 (DE-600)219231-7 (DE-576)015003663 0001-4966 nnns volume:142 year:2017 number:4 pages:2600-2600 http://dx.doi.org/10.1121/1.5014516 Volltext http://dx.doi.org/10.1121/1.5014516 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-MUS GBV_ILN_59 GBV_ILN_60 GBV_ILN_70 GBV_ILN_120 GBV_ILN_170 GBV_ILN_201 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2027 GBV_ILN_2045 GBV_ILN_2192 GBV_ILN_2256 GBV_ILN_4219 GBV_ILN_4315 GBV_ILN_4319 GBV_ILN_4700 EQ 1000: 33.12 AVZ 50.36 AVZ AR 142 2017 4 2600-2600 |
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10.1121/1.5014516 doi PQ20171228 (DE-627)OLC1997723220 (DE-599)GBVOLC1997723220 (PRQ)scitation_primary_10_1121_1_50145160 (KEY)0112299120170000142000402600bonerepairandultrasoundstimulationaninsightintothe DE-627 ger DE-627 rakwb 530 DE-600 LING fid EQ 1000: AVZ rvk 33.12 bkl 50.36 bkl Baron, Cécile verfasserin aut Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. Nutzungsrecht: © Acoustical Society of America Guivier-Curien, Carine oth Nguyen, Vu-Hieu oth Naili, Salah oth Enthalten in The journal of the Acoustical Society of America Melville, NY : AIP, 1929 142(2017), 4, Seite 2600-2600 (DE-627)129550264 (DE-600)219231-7 (DE-576)015003663 0001-4966 nnns volume:142 year:2017 number:4 pages:2600-2600 http://dx.doi.org/10.1121/1.5014516 Volltext http://dx.doi.org/10.1121/1.5014516 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-MUS GBV_ILN_59 GBV_ILN_60 GBV_ILN_70 GBV_ILN_120 GBV_ILN_170 GBV_ILN_201 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2027 GBV_ILN_2045 GBV_ILN_2192 GBV_ILN_2256 GBV_ILN_4219 GBV_ILN_4315 GBV_ILN_4319 GBV_ILN_4700 EQ 1000: 33.12 AVZ 50.36 AVZ AR 142 2017 4 2600-2600 |
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10.1121/1.5014516 doi PQ20171228 (DE-627)OLC1997723220 (DE-599)GBVOLC1997723220 (PRQ)scitation_primary_10_1121_1_50145160 (KEY)0112299120170000142000402600bonerepairandultrasoundstimulationaninsightintothe DE-627 ger DE-627 rakwb 530 DE-600 LING fid EQ 1000: AVZ rvk 33.12 bkl 50.36 bkl Baron, Cécile verfasserin aut Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. Nutzungsrecht: © Acoustical Society of America Guivier-Curien, Carine oth Nguyen, Vu-Hieu oth Naili, Salah oth Enthalten in The journal of the Acoustical Society of America Melville, NY : AIP, 1929 142(2017), 4, Seite 2600-2600 (DE-627)129550264 (DE-600)219231-7 (DE-576)015003663 0001-4966 nnns volume:142 year:2017 number:4 pages:2600-2600 http://dx.doi.org/10.1121/1.5014516 Volltext http://dx.doi.org/10.1121/1.5014516 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-MUS GBV_ILN_59 GBV_ILN_60 GBV_ILN_70 GBV_ILN_120 GBV_ILN_170 GBV_ILN_201 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2027 GBV_ILN_2045 GBV_ILN_2192 GBV_ILN_2256 GBV_ILN_4219 GBV_ILN_4315 GBV_ILN_4319 GBV_ILN_4700 EQ 1000: 33.12 AVZ 50.36 AVZ AR 142 2017 4 2600-2600 |
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10.1121/1.5014516 doi PQ20171228 (DE-627)OLC1997723220 (DE-599)GBVOLC1997723220 (PRQ)scitation_primary_10_1121_1_50145160 (KEY)0112299120170000142000402600bonerepairandultrasoundstimulationaninsightintothe DE-627 ger DE-627 rakwb 530 DE-600 LING fid EQ 1000: AVZ rvk 33.12 bkl 50.36 bkl Baron, Cécile verfasserin aut Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. Nutzungsrecht: © Acoustical Society of America Guivier-Curien, Carine oth Nguyen, Vu-Hieu oth Naili, Salah oth Enthalten in The journal of the Acoustical Society of America Melville, NY : AIP, 1929 142(2017), 4, Seite 2600-2600 (DE-627)129550264 (DE-600)219231-7 (DE-576)015003663 0001-4966 nnns volume:142 year:2017 number:4 pages:2600-2600 http://dx.doi.org/10.1121/1.5014516 Volltext http://dx.doi.org/10.1121/1.5014516 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-MUS GBV_ILN_59 GBV_ILN_60 GBV_ILN_70 GBV_ILN_120 GBV_ILN_170 GBV_ILN_201 GBV_ILN_2006 GBV_ILN_2011 GBV_ILN_2027 GBV_ILN_2045 GBV_ILN_2192 GBV_ILN_2256 GBV_ILN_4219 GBV_ILN_4315 GBV_ILN_4319 GBV_ILN_4700 EQ 1000: 33.12 AVZ 50.36 AVZ AR 142 2017 4 2600-2600 |
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Bone repair and ultrasound stimulation: An insight into the interaction of LIPUS with the bone callus through a multiscale computational study |
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In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. |
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In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. |
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In the 1950s, the effect of ultrasound stimulation on bone healing has been discovered. Nowadays, Low Intensity Pulsed Ultrasound Stimulation (LIPUS) is admitted to influence the mechanotransduction of bone. Nevertheless, despite a growing literature—cell cultures, animal models, and clinical studies—the underlying physical and biological mechanisms of LIPUS on bone healing are still misunderstood. Inspired from previous studies on the mechanotransduction induced by physiological loading, this work focuses on the effect of LIPUS on the osteocytes. These bone cells are thought to be the principal mechanosensors of bone. They are ubiquitous inside the bone matrix, immersed in the lacuno-canalicular network (LCN) filled with interstitial fluid (IF). The goal is to relate the ultrasound stimulation applied at the tissue scale, to the biological response at the cell scale. To tackle this question, two finite element models were implemented in the commercial software Comsol Multiphysics. The tissue-scale model considers an anisotropic poroelastic matrix to evaluate the IF pressure gradient induced by LIPUS into the LCN. Then, in the cell-scale model, the IF shear stress magnitude and the induced drag forces applied on osteocyte process are calculated and compared with levels of cell activation recorded in literature. |
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