A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles

Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Schiavone, Giuseppe [verfasserIn] Jones, Thomas Price, Dennis McPhillips, Rachael Jiang, Yun Qiu, Zhen Meggs, Carl Mahboob, Syed O. Eljamel, Sam Button, Tim W. Demore, Christine E. M. Cochran, Sandy Desmulliez, Marc P. Y.

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit

Anmerkung:	© The Author(s) 2016

Übergeordnetes Werk:	Enthalten in: Microsystem technologies - Springer Berlin Heidelberg, 1994, 23(2016), 9 vom: 18. Jan., Seite 3881-3891
Übergeordnetes Werk:	volume:23 ; year:2016 ; number:9 ; day:18 ; month:01 ; pages:3881-3891

Links:	Volltext

DOI / URN:	10.1007/s00542-015-2775-1

Katalog-ID:	OLC203494903X

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700	1		\|a McPhillips, Rachael \|4 aut
700	1		\|a Jiang, Yun \|4 aut
700	1		\|a Qiu, Zhen \|4 aut
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700	1		\|a Mahboob, Syed O. \|4 aut
700	1		\|a Eljamel, Sam \|4 aut
700	1		\|a Button, Tim W. \|4 aut
700	1		\|a Demore, Christine E. M. \|4 aut
700	1		\|a Cochran, Sandy \|4 aut
700	1		\|a Desmulliez, Marc P. Y. \|4 aut
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allfields	10.1007/s00542-015-2775-1 doi (DE-627)OLC203494903X (DE-He213)s00542-015-2775-1-p DE-627 ger DE-627 rakwb eng 620 VZ 510 VZ Schiavone, Giuseppe verfasserin (orcid)0000-0001-7121-9825 aut A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2016 Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit Jones, Thomas aut Price, Dennis aut McPhillips, Rachael aut Jiang, Yun aut Qiu, Zhen aut Meggs, Carl aut Mahboob, Syed O. aut Eljamel, Sam aut Button, Tim W. aut Demore, Christine E. M. aut Cochran, Sandy aut Desmulliez, Marc P. Y. aut Enthalten in Microsystem technologies Springer Berlin Heidelberg, 1994 23(2016), 9 vom: 18. Jan., Seite 3881-3891 (DE-627)182644278 (DE-600)1223008-X (DE-576)045302146 0946-7076 nnns volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891 https://doi.org/10.1007/s00542-015-2775-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_70 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 23 2016 9 18 01 3881-3891
spelling	10.1007/s00542-015-2775-1 doi (DE-627)OLC203494903X (DE-He213)s00542-015-2775-1-p DE-627 ger DE-627 rakwb eng 620 VZ 510 VZ Schiavone, Giuseppe verfasserin (orcid)0000-0001-7121-9825 aut A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2016 Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit Jones, Thomas aut Price, Dennis aut McPhillips, Rachael aut Jiang, Yun aut Qiu, Zhen aut Meggs, Carl aut Mahboob, Syed O. aut Eljamel, Sam aut Button, Tim W. aut Demore, Christine E. M. aut Cochran, Sandy aut Desmulliez, Marc P. Y. aut Enthalten in Microsystem technologies Springer Berlin Heidelberg, 1994 23(2016), 9 vom: 18. Jan., Seite 3881-3891 (DE-627)182644278 (DE-600)1223008-X (DE-576)045302146 0946-7076 nnns volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891 https://doi.org/10.1007/s00542-015-2775-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_70 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 23 2016 9 18 01 3881-3891
allfields_unstemmed	10.1007/s00542-015-2775-1 doi (DE-627)OLC203494903X (DE-He213)s00542-015-2775-1-p DE-627 ger DE-627 rakwb eng 620 VZ 510 VZ Schiavone, Giuseppe verfasserin (orcid)0000-0001-7121-9825 aut A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2016 Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit Jones, Thomas aut Price, Dennis aut McPhillips, Rachael aut Jiang, Yun aut Qiu, Zhen aut Meggs, Carl aut Mahboob, Syed O. aut Eljamel, Sam aut Button, Tim W. aut Demore, Christine E. M. aut Cochran, Sandy aut Desmulliez, Marc P. Y. aut Enthalten in Microsystem technologies Springer Berlin Heidelberg, 1994 23(2016), 9 vom: 18. Jan., Seite 3881-3891 (DE-627)182644278 (DE-600)1223008-X (DE-576)045302146 0946-7076 nnns volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891 https://doi.org/10.1007/s00542-015-2775-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_70 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 23 2016 9 18 01 3881-3891
allfieldsGer	10.1007/s00542-015-2775-1 doi (DE-627)OLC203494903X (DE-He213)s00542-015-2775-1-p DE-627 ger DE-627 rakwb eng 620 VZ 510 VZ Schiavone, Giuseppe verfasserin (orcid)0000-0001-7121-9825 aut A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2016 Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit Jones, Thomas aut Price, Dennis aut McPhillips, Rachael aut Jiang, Yun aut Qiu, Zhen aut Meggs, Carl aut Mahboob, Syed O. aut Eljamel, Sam aut Button, Tim W. aut Demore, Christine E. M. aut Cochran, Sandy aut Desmulliez, Marc P. Y. aut Enthalten in Microsystem technologies Springer Berlin Heidelberg, 1994 23(2016), 9 vom: 18. Jan., Seite 3881-3891 (DE-627)182644278 (DE-600)1223008-X (DE-576)045302146 0946-7076 nnns volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891 https://doi.org/10.1007/s00542-015-2775-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_70 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 23 2016 9 18 01 3881-3891
allfieldsSound	10.1007/s00542-015-2775-1 doi (DE-627)OLC203494903X (DE-He213)s00542-015-2775-1-p DE-627 ger DE-627 rakwb eng 620 VZ 510 VZ Schiavone, Giuseppe verfasserin (orcid)0000-0001-7121-9825 aut A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2016 Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit Jones, Thomas aut Price, Dennis aut McPhillips, Rachael aut Jiang, Yun aut Qiu, Zhen aut Meggs, Carl aut Mahboob, Syed O. aut Eljamel, Sam aut Button, Tim W. aut Demore, Christine E. M. aut Cochran, Sandy aut Desmulliez, Marc P. Y. aut Enthalten in Microsystem technologies Springer Berlin Heidelberg, 1994 23(2016), 9 vom: 18. Jan., Seite 3881-3891 (DE-627)182644278 (DE-600)1223008-X (DE-576)045302146 0946-7076 nnns volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891 https://doi.org/10.1007/s00542-015-2775-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_70 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 23 2016 9 18 01 3881-3891
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source	Enthalten in Microsystem technologies 23(2016), 9 vom: 18. Jan., Seite 3881-3891 volume:23 year:2016 number:9 day:18 month:01 pages:3881-3891
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However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. 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author	Schiavone, Giuseppe
spellingShingle	Schiavone, Giuseppe ddc 620 ddc 510 misc Bond Line misc Bonding Site misc Anisotropic Conductive Film misc Anisotropic Conductive misc Application Specific Integrate Circuit A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
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topic_title	620 VZ 510 VZ A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles Bond Line Bonding Site Anisotropic Conductive Film Anisotropic Conductive Application Specific Integrate Circuit
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title	A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
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title_full	A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
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title_sort	a highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
title_auth	A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
abstract	Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. © The Author(s) 2016
abstractGer	Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. © The Author(s) 2016
abstract_unstemmed	Abstract State-of-the-art neurosurgery intervention relies heavily on information from tissue imaging taken at a pre-operative stage. However, the data retrieved prior to performing an opening in the patient’s skull may present inconsistencies with respect to the tissue position observed by the surgeon during intervention, due to both the pulsing vasculature and possible displacements of the brain. The consequent uncertainty of the actual tissue position during the insertion of surgical tools has resulted in great interest in real-time guidance techniques. Ultrasound guidance during neurosurgery is a promising method for imaging the tissue while inserting surgical tools, as it may provide high resolution images. Microfabrication techniques have enabled the miniaturisation of ultrasound arrays to fit needle gauges below 2 mm inner diameter. However, the integration of array transducers in surgical needles requires the development of advanced interconnection techniques that can provide an interface between the microscale array elements and the macroscale connectors to the driving electronics. This paper presents progress towards a novel packaging scheme that uses a thin flexible printed circuit board (PCB) wound inside a surgical needle. The flexible PCB is connected to a probe at the tip of the needle by means of magnetically aligned anisotropic conductive paste. This bonding technology offers higher compactness compared to conventional wire bonding, as the individual electrical connections are isolated from one another within the volume of the paste line, and applies a reduced thermal load compared to thermo-compression or eutectic packaging techniques. The reduction in the volume required for the interconnection allows for denser wiring of ultrasound probes within interventional tools. This allows the integration of arrays with higher element counts in confined packages, potentially enabling multi-modality imaging with Raman, OCT, and impediography. Promising experimental results and a prototype needle assembly are presented to demonstrate the viability of the proposed packaging scheme. The progress reported in this work are steps towards the production of fully-functional imaging-enabled needles that can be used as surgical guidance tools. © The Author(s) 2016
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container_issue	9
title_short	A highly compact packaging concept for ultrasound transducer arrays embedded in neurosurgical needles
url	https://doi.org/10.1007/s00542-015-2775-1
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author2	Jones, Thomas Price, Dennis McPhillips, Rachael Jiang, Yun Qiu, Zhen Meggs, Carl Mahboob, Syed O. Eljamel, Sam Button, Tim W. Demore, Christine E. M. Cochran, Sandy Desmulliez, Marc P. Y.
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