Nerve conduction block utilising high-frequency alternating current
Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters fo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kilgore, K. L. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Anmerkung: |
© IFMBE 2004 |
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| Übergeordnetes Werk: |
Enthalten in: Medical & biological engineering & computing - Springer-Verlag, 1977, 42(2004), 3 vom: Mai, Seite 394-406 |
|---|---|
| Übergeordnetes Werk: |
volume:42 ; year:2004 ; number:3 ; month:05 ; pages:394-406 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF02344716 |
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OLC2038680221 |
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| 520 | |a Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. | ||
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10.1007/BF02344716 doi (DE-627)OLC2038680221 (DE-He213)BF02344716-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Kilgore, K. L. verfasserin aut Nerve conduction block utilising high-frequency alternating current 2004 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2004 Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. Conduction block Alternating current Depolarisation High frequency Bhadra, N. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 42(2004), 3 vom: Mai, Seite 394-406 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:42 year:2004 number:3 month:05 pages:394-406 https://doi.org/10.1007/BF02344716 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 42 2004 3 05 394-406 |
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10.1007/BF02344716 doi (DE-627)OLC2038680221 (DE-He213)BF02344716-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Kilgore, K. L. verfasserin aut Nerve conduction block utilising high-frequency alternating current 2004 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2004 Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. Conduction block Alternating current Depolarisation High frequency Bhadra, N. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 42(2004), 3 vom: Mai, Seite 394-406 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:42 year:2004 number:3 month:05 pages:394-406 https://doi.org/10.1007/BF02344716 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 42 2004 3 05 394-406 |
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10.1007/BF02344716 doi (DE-627)OLC2038680221 (DE-He213)BF02344716-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Kilgore, K. L. verfasserin aut Nerve conduction block utilising high-frequency alternating current 2004 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2004 Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. Conduction block Alternating current Depolarisation High frequency Bhadra, N. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 42(2004), 3 vom: Mai, Seite 394-406 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:42 year:2004 number:3 month:05 pages:394-406 https://doi.org/10.1007/BF02344716 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 42 2004 3 05 394-406 |
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10.1007/BF02344716 doi (DE-627)OLC2038680221 (DE-He213)BF02344716-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Kilgore, K. L. verfasserin aut Nerve conduction block utilising high-frequency alternating current 2004 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2004 Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. Conduction block Alternating current Depolarisation High frequency Bhadra, N. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 42(2004), 3 vom: Mai, Seite 394-406 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:42 year:2004 number:3 month:05 pages:394-406 https://doi.org/10.1007/BF02344716 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 42 2004 3 05 394-406 |
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10.1007/BF02344716 doi (DE-627)OLC2038680221 (DE-He213)BF02344716-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Kilgore, K. L. verfasserin aut Nerve conduction block utilising high-frequency alternating current 2004 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2004 Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. Conduction block Alternating current Depolarisation High frequency Bhadra, N. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 42(2004), 3 vom: Mai, Seite 394-406 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:42 year:2004 number:3 month:05 pages:394-406 https://doi.org/10.1007/BF02344716 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 42 2004 3 05 394-406 |
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Nerve conduction block utilising high-frequency alternating current |
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(DE-627)OLC2038680221 (DE-He213)BF02344716-p |
| title_full |
Nerve conduction block utilising high-frequency alternating current |
| author_sort |
Kilgore, K. L. |
| journal |
Medical & biological engineering & computing |
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Medical & biological engineering & computing |
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eng |
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600 - Technology 500 - Science |
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marc |
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2004 |
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txt |
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394 |
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Kilgore, K. L. Bhadra, N. |
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42 |
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Kilgore, K. L. |
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10.1007/BF02344716 |
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610 660 570 |
| title_sort |
nerve conduction block utilising high-frequency alternating current |
| title_auth |
Nerve conduction block utilising high-frequency alternating current |
| abstract |
Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. © IFMBE 2004 |
| abstractGer |
Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. © IFMBE 2004 |
| abstract_unstemmed |
Abstract High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nerve/gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2 kHz to 20 kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3–5 kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 μC $ phase^{−1} $. It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity. © IFMBE 2004 |
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| title_short |
Nerve conduction block utilising high-frequency alternating current |
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https://doi.org/10.1007/BF02344716 |
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