Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts
Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Graf, I. M. [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2005 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© IFMBE 2005 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Medical & biological engineering & computing - Springer-Verlag, 1977, 43(2005), 6 vom: Nov., Seite 783-792 |
|---|---|
| Übergeordnetes Werk: |
volume:43 ; year:2005 ; number:6 ; month:11 ; pages:783-792 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF02430958 |
|---|
| Katalog-ID: |
OLC2038681929 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2038681929 | ||
| 003 | DE-627 | ||
| 005 | 20230508183124.0 | ||
| 007 | tu | ||
| 008 | 200819s2005 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF02430958 |2 doi | |
| 035 | |a (DE-627)OLC2038681929 | ||
| 035 | |a (DE-He213)BF02430958-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |a 660 |a 570 |q VZ |
| 084 | |a 12 |2 ssgn | ||
| 100 | 1 | |a Graf, I. M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| 264 | 1 | |c 2005 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © IFMBE 2005 | ||
| 520 | |a Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. | ||
| 650 | 4 | |a Simulation | |
| 650 | 4 | |a Electrophysiological heterogeneity | |
| 650 | 4 | |a Virual human left ventricle | |
| 650 | 4 | |a Healthy and failing heart | |
| 650 | 4 | |a Electrical stimulation | |
| 700 | 1 | |a Seemann, G. |4 aut | |
| 700 | 1 | |a Weiß, D. L. |4 aut | |
| 700 | 1 | |a Dössel, O. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medical & biological engineering & computing |d Springer-Verlag, 1977 |g 43(2005), 6 vom: Nov., Seite 783-792 |w (DE-627)129858552 |w (DE-600)282327-5 |w (DE-576)015165507 |x 0140-0118 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2005 |g number:6 |g month:11 |g pages:783-792 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/BF02430958 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-TEC | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-MAT | ||
| 912 | |a GBV_ILN_32 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_118 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4219 | ||
| 912 | |a GBV_ILN_4306 | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2005 |e 6 |c 11 |h 783-792 | ||
| author_variant |
i m g im img g s gs d l w dl dlw o d od |
|---|---|
| matchkey_str |
article:01400118:2005----::nlecoeetohsooiahtrgniynlcrcltmltoiha |
| hierarchy_sort_str |
2005 |
| publishDate |
2005 |
| allfields |
10.1007/BF02430958 doi (DE-627)OLC2038681929 (DE-He213)BF02430958-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Graf, I. M. verfasserin aut Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2005 Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation Seemann, G. aut Weiß, D. L. aut Dössel, O. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 43(2005), 6 vom: Nov., Seite 783-792 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:43 year:2005 number:6 month:11 pages:783-792 https://doi.org/10.1007/BF02430958 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 43 2005 6 11 783-792 |
| spelling |
10.1007/BF02430958 doi (DE-627)OLC2038681929 (DE-He213)BF02430958-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Graf, I. M. verfasserin aut Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2005 Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation Seemann, G. aut Weiß, D. L. aut Dössel, O. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 43(2005), 6 vom: Nov., Seite 783-792 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:43 year:2005 number:6 month:11 pages:783-792 https://doi.org/10.1007/BF02430958 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 43 2005 6 11 783-792 |
| allfields_unstemmed |
10.1007/BF02430958 doi (DE-627)OLC2038681929 (DE-He213)BF02430958-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Graf, I. M. verfasserin aut Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2005 Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation Seemann, G. aut Weiß, D. L. aut Dössel, O. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 43(2005), 6 vom: Nov., Seite 783-792 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:43 year:2005 number:6 month:11 pages:783-792 https://doi.org/10.1007/BF02430958 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 43 2005 6 11 783-792 |
| allfieldsGer |
10.1007/BF02430958 doi (DE-627)OLC2038681929 (DE-He213)BF02430958-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Graf, I. M. verfasserin aut Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2005 Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation Seemann, G. aut Weiß, D. L. aut Dössel, O. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 43(2005), 6 vom: Nov., Seite 783-792 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:43 year:2005 number:6 month:11 pages:783-792 https://doi.org/10.1007/BF02430958 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 43 2005 6 11 783-792 |
| allfieldsSound |
10.1007/BF02430958 doi (DE-627)OLC2038681929 (DE-He213)BF02430958-p DE-627 ger DE-627 rakwb eng 610 660 570 VZ 12 ssgn Graf, I. M. verfasserin aut Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © IFMBE 2005 Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation Seemann, G. aut Weiß, D. L. aut Dössel, O. aut Enthalten in Medical & biological engineering & computing Springer-Verlag, 1977 43(2005), 6 vom: Nov., Seite 783-792 (DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 0140-0118 nnns volume:43 year:2005 number:6 month:11 pages:783-792 https://doi.org/10.1007/BF02430958 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 AR 43 2005 6 11 783-792 |
| language |
English |
| source |
Enthalten in Medical & biological engineering & computing 43(2005), 6 vom: Nov., Seite 783-792 volume:43 year:2005 number:6 month:11 pages:783-792 |
| sourceStr |
Enthalten in Medical & biological engineering & computing 43(2005), 6 vom: Nov., Seite 783-792 volume:43 year:2005 number:6 month:11 pages:783-792 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Medical & biological engineering & computing |
| authorswithroles_txt_mv |
Graf, I. M. @@aut@@ Seemann, G. @@aut@@ Weiß, D. L. @@aut@@ Dössel, O. @@aut@@ |
| publishDateDaySort_date |
2005-11-01T00:00:00Z |
| hierarchy_top_id |
129858552 |
| dewey-sort |
3610 |
| id |
OLC2038681929 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2038681929</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230508183124.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200819s2005 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/BF02430958</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2038681929</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)BF02430958-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="a">660</subfield><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">12</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Graf, I. M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2005</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© IFMBE 2005</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Simulation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electrophysiological heterogeneity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Virual human left ventricle</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Healthy and failing heart</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electrical stimulation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Seemann, G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weiß, D. L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dössel, O.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Medical & biological engineering & computing</subfield><subfield code="d">Springer-Verlag, 1977</subfield><subfield code="g">43(2005), 6 vom: Nov., Seite 783-792</subfield><subfield code="w">(DE-627)129858552</subfield><subfield code="w">(DE-600)282327-5</subfield><subfield code="w">(DE-576)015165507</subfield><subfield code="x">0140-0118</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:6</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:783-792</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/BF02430958</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-MAT</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">43</subfield><subfield code="j">2005</subfield><subfield code="e">6</subfield><subfield code="c">11</subfield><subfield code="h">783-792</subfield></datafield></record></collection>
|
| author |
Graf, I. M. |
| spellingShingle |
Graf, I. M. ddc 610 ssgn 12 misc Simulation misc Electrophysiological heterogeneity misc Virual human left ventricle misc Healthy and failing heart misc Electrical stimulation Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| authorStr |
Graf, I. M. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)129858552 |
| format |
Article |
| dewey-ones |
610 - Medicine & health 660 - Chemical engineering 570 - Life sciences; biology |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
0140-0118 |
| topic_title |
610 660 570 VZ 12 ssgn Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts Simulation Electrophysiological heterogeneity Virual human left ventricle Healthy and failing heart Electrical stimulation |
| topic |
ddc 610 ssgn 12 misc Simulation misc Electrophysiological heterogeneity misc Virual human left ventricle misc Healthy and failing heart misc Electrical stimulation |
| topic_unstemmed |
ddc 610 ssgn 12 misc Simulation misc Electrophysiological heterogeneity misc Virual human left ventricle misc Healthy and failing heart misc Electrical stimulation |
| topic_browse |
ddc 610 ssgn 12 misc Simulation misc Electrophysiological heterogeneity misc Virual human left ventricle misc Healthy and failing heart misc Electrical stimulation |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| hierarchy_parent_title |
Medical & biological engineering & computing |
| hierarchy_parent_id |
129858552 |
| dewey-tens |
610 - Medicine & health 660 - Chemical engineering 570 - Life sciences; biology |
| hierarchy_top_title |
Medical & biological engineering & computing |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)129858552 (DE-600)282327-5 (DE-576)015165507 |
| title |
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| ctrlnum |
(DE-627)OLC2038681929 (DE-He213)BF02430958-p |
| title_full |
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| author_sort |
Graf, I. M. |
| journal |
Medical & biological engineering & computing |
| journalStr |
Medical & biological engineering & computing |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2005 |
| contenttype_str_mv |
txt |
| container_start_page |
783 |
| author_browse |
Graf, I. M. Seemann, G. Weiß, D. L. Dössel, O. |
| container_volume |
43 |
| class |
610 660 570 VZ 12 ssgn |
| format_se |
Aufsätze |
| author-letter |
Graf, I. M. |
| doi_str_mv |
10.1007/BF02430958 |
| dewey-full |
610 660 570 |
| title_sort |
influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| title_auth |
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| abstract |
Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. © IFMBE 2005 |
| abstractGer |
Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. © IFMBE 2005 |
| abstract_unstemmed |
Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features. © IFMBE 2005 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT GBV_ILN_32 GBV_ILN_40 GBV_ILN_70 GBV_ILN_105 GBV_ILN_118 GBV_ILN_2006 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4306 |
| container_issue |
6 |
| title_short |
Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts |
| url |
https://doi.org/10.1007/BF02430958 |
| remote_bool |
false |
| author2 |
Seemann, G. Weiß, D. L. Dössel, O. |
| author2Str |
Seemann, G. Weiß, D. L. Dössel, O. |
| ppnlink |
129858552 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/BF02430958 |
| up_date |
2024-07-03T19:50:05.400Z |
| _version_ |
1803588684114558976 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2038681929</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230508183124.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200819s2005 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/BF02430958</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2038681929</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)BF02430958-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="a">660</subfield><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">12</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Graf, I. M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Influence of electrophysiological heterogeneity on electrical stimulation in healthy and failing human hearts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2005</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© IFMBE 2005</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The application of strong electrical stimuli is a common method used for terminating irregular cardiac behaviour. The study presents the influence of electrophysiological heterogeneity on the response of human hearts to electrical stimulation. The human electrophysiology was simulated using the ten Tusscher-Noble-Noble-Panfilov cell model. The anisotropic propagation of depolarisation in three-dimensional virtual myocardial preparations was calculated using bidomain equations. The research was carried out on different types of virtual cardiac wedge. The selection of the modelling parameters emphasises the influence of cellular electrophysiology on the response of the human myocardium to electrical stimulation. The simulations were initially performed on a virtual cardiac control model characterised by electrophysiological homogeneity. The second preparation incorporated the transmural electrophysiological heterogeneity characteristic of the healthy human heart. In the third model type, the normal electrophysiological heterogeneity was modified by the conditions of heart failure. The main currents responsible for repolarisation ($ I_{to} $, $ I_{Ks} $ and $ I_{Kl} $) were reduced by 25%. Successively, [$ Na^{+} $]i was increased by the regulation of the $ Na^{+} $−$ Ca^{2+} $ exchange function, and fibrosis was represented by decreasing electrical conductivity. Various electrical stimulation configurations were used to investigate the differences in the responses of the three different models. Monophasic and biphasic electrical stimuli were applied through rectangular paddles and needle electrodes. A whole systolic period was simulated. The distribution of the transmembrane voltage indicated that the modification of electrophysiological heterogeneity induced drastic changes during the repolarisation phase. The results illustrated that each of the heart failure conditions amplifies the modification of the response of the myocardium to electrical stimulation. Therefore a theoretical model of the failing human heart must incorporate all the characteristic features.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Simulation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electrophysiological heterogeneity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Virual human left ventricle</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Healthy and failing heart</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electrical stimulation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Seemann, G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weiß, D. L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dössel, O.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Medical & biological engineering & computing</subfield><subfield code="d">Springer-Verlag, 1977</subfield><subfield code="g">43(2005), 6 vom: Nov., Seite 783-792</subfield><subfield code="w">(DE-627)129858552</subfield><subfield code="w">(DE-600)282327-5</subfield><subfield code="w">(DE-576)015165507</subfield><subfield code="x">0140-0118</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:6</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:783-792</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/BF02430958</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-MAT</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">43</subfield><subfield code="j">2005</subfield><subfield code="e">6</subfield><subfield code="c">11</subfield><subfield code="h">783-792</subfield></datafield></record></collection>
|
| score |
7.402767 |