Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture
Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mejia-Sanchez, Fernando [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag GmbH Germany 2017 |
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| Übergeordnetes Werk: |
Enthalten in: Environmental science and pollution research - Springer Berlin Heidelberg, 1994, 25(2017), 1 vom: 19. Okt., Seite 601-606 |
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| Übergeordnetes Werk: |
volume:25 ; year:2017 ; number:1 ; day:19 ; month:10 ; pages:601-606 |
| Links: |
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| DOI / URN: |
10.1007/s11356-017-0410-7 |
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OLC2040504133 |
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| 520 | |a Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. | ||
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10.1007/s11356-017-0410-7 doi (DE-627)OLC2040504133 (DE-He213)s11356-017-0410-7-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Mejia-Sanchez, Fernando verfasserin aut Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany 2017 Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. GST enzymatic activity GSTT1 enzymatic activity Pesticides Floriculturists Montenegro-Morales, Laura Patricia aut Castillo-Cadena, Julieta aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 25(2017), 1 vom: 19. Okt., Seite 601-606 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:25 year:2017 number:1 day:19 month:10 pages:601-606 https://doi.org/10.1007/s11356-017-0410-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4277 AR 25 2017 1 19 10 601-606 |
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10.1007/s11356-017-0410-7 doi (DE-627)OLC2040504133 (DE-He213)s11356-017-0410-7-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Mejia-Sanchez, Fernando verfasserin aut Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany 2017 Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. GST enzymatic activity GSTT1 enzymatic activity Pesticides Floriculturists Montenegro-Morales, Laura Patricia aut Castillo-Cadena, Julieta aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 25(2017), 1 vom: 19. Okt., Seite 601-606 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:25 year:2017 number:1 day:19 month:10 pages:601-606 https://doi.org/10.1007/s11356-017-0410-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4277 AR 25 2017 1 19 10 601-606 |
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10.1007/s11356-017-0410-7 doi (DE-627)OLC2040504133 (DE-He213)s11356-017-0410-7-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Mejia-Sanchez, Fernando verfasserin aut Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany 2017 Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. GST enzymatic activity GSTT1 enzymatic activity Pesticides Floriculturists Montenegro-Morales, Laura Patricia aut Castillo-Cadena, Julieta aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 25(2017), 1 vom: 19. Okt., Seite 601-606 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:25 year:2017 number:1 day:19 month:10 pages:601-606 https://doi.org/10.1007/s11356-017-0410-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4277 AR 25 2017 1 19 10 601-606 |
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10.1007/s11356-017-0410-7 doi (DE-627)OLC2040504133 (DE-He213)s11356-017-0410-7-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Mejia-Sanchez, Fernando verfasserin aut Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany 2017 Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. GST enzymatic activity GSTT1 enzymatic activity Pesticides Floriculturists Montenegro-Morales, Laura Patricia aut Castillo-Cadena, Julieta aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 25(2017), 1 vom: 19. Okt., Seite 601-606 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:25 year:2017 number:1 day:19 month:10 pages:601-606 https://doi.org/10.1007/s11356-017-0410-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4277 AR 25 2017 1 19 10 601-606 |
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10.1007/s11356-017-0410-7 doi (DE-627)OLC2040504133 (DE-He213)s11356-017-0410-7-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Mejia-Sanchez, Fernando verfasserin aut Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture 2017 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany 2017 Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. GST enzymatic activity GSTT1 enzymatic activity Pesticides Floriculturists Montenegro-Morales, Laura Patricia aut Castillo-Cadena, Julieta aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 25(2017), 1 vom: 19. Okt., Seite 601-606 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:25 year:2017 number:1 day:19 month:10 pages:601-606 https://doi.org/10.1007/s11356-017-0410-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4277 AR 25 2017 1 19 10 601-606 |
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enzymatic activity induction of gst-family isoenzymes from pesticide mixture used in floriculture |
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Enzymatic activity induction of GST-family isoenzymes from pesticide mixture used in floriculture |
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Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. © Springer-Verlag GmbH Germany 2017 |
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Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. © Springer-Verlag GmbH Germany 2017 |
| abstract_unstemmed |
Abstract Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic activities in the municipalities of Villa Guerrero and Atlacomulco; pesticides, applied as mixtures, are intensively used in this activity. In this study, total GST enzymatic activity and glutathione S-transferases theta 1 (GSTT1) enzymatic activity were calculated for a group of floriculture workers exposed to pesticides and for an unexposed group. The former comprised 169 floriculture workers, while the latter, 96 students. The value of the median GST enzymatic activity in the exposed group was 0.560 and 0.169 μmol/min/mL in the unexposed individuals. GSTT1 activity was 1.234 μmol/min/mL in the exposed group and 0.221 μmol/min/mL in the unexposed group. Mann-Whitney U test showed a significant difference between these groups, for both total GST and GSTT1, p < 0.001. Our results show that exposure to pesticides increases the activities of total GST and GSTT1 enzymes. © Springer-Verlag GmbH Germany 2017 |
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