Magnetically actuable polymer nanocomposites for bioengineering applications
Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mack, Julia J. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science - Kluwer Academic Publishers-Plenum Publishers, 1966, 42(2007), 15 vom: 17. Apr., Seite 6139-6147 |
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| Übergeordnetes Werk: |
volume:42 ; year:2007 ; number:15 ; day:17 ; month:04 ; pages:6139-6147 |
| Links: |
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| DOI / URN: |
10.1007/s10853-006-0982-y |
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| Katalog-ID: |
OLC2046329104 |
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| 520 | |a Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. | ||
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10.1007/s10853-006-0982-y doi (DE-627)OLC2046329104 (DE-He213)s10853-006-0982-y-p DE-627 ger DE-627 rakwb eng 670 VZ Mack, Julia J. verfasserin aut Magnetically actuable polymer nanocomposites for bioengineering applications 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2007 Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. Composite Film Magnetic Force Field Gradient Magnetic Field Gradient IEC6 Cell Cox, Brian N. aut Lee, Min aut Dunn, James C. Y. aut Wu, Benjamin W. aut Enthalten in Journal of materials science Kluwer Academic Publishers-Plenum Publishers, 1966 42(2007), 15 vom: 17. Apr., Seite 6139-6147 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:42 year:2007 number:15 day:17 month:04 pages:6139-6147 https://doi.org/10.1007/s10853-006-0982-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_20 GBV_ILN_21 GBV_ILN_23 GBV_ILN_30 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_100 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_4046 GBV_ILN_4305 GBV_ILN_4323 AR 42 2007 15 17 04 6139-6147 |
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10.1007/s10853-006-0982-y doi (DE-627)OLC2046329104 (DE-He213)s10853-006-0982-y-p DE-627 ger DE-627 rakwb eng 670 VZ Mack, Julia J. verfasserin aut Magnetically actuable polymer nanocomposites for bioengineering applications 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2007 Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. Composite Film Magnetic Force Field Gradient Magnetic Field Gradient IEC6 Cell Cox, Brian N. aut Lee, Min aut Dunn, James C. Y. aut Wu, Benjamin W. aut Enthalten in Journal of materials science Kluwer Academic Publishers-Plenum Publishers, 1966 42(2007), 15 vom: 17. Apr., Seite 6139-6147 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:42 year:2007 number:15 day:17 month:04 pages:6139-6147 https://doi.org/10.1007/s10853-006-0982-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_20 GBV_ILN_21 GBV_ILN_23 GBV_ILN_30 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_100 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_4046 GBV_ILN_4305 GBV_ILN_4323 AR 42 2007 15 17 04 6139-6147 |
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10.1007/s10853-006-0982-y doi (DE-627)OLC2046329104 (DE-He213)s10853-006-0982-y-p DE-627 ger DE-627 rakwb eng 670 VZ Mack, Julia J. verfasserin aut Magnetically actuable polymer nanocomposites for bioengineering applications 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2007 Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. Composite Film Magnetic Force Field Gradient Magnetic Field Gradient IEC6 Cell Cox, Brian N. aut Lee, Min aut Dunn, James C. Y. aut Wu, Benjamin W. aut Enthalten in Journal of materials science Kluwer Academic Publishers-Plenum Publishers, 1966 42(2007), 15 vom: 17. Apr., Seite 6139-6147 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:42 year:2007 number:15 day:17 month:04 pages:6139-6147 https://doi.org/10.1007/s10853-006-0982-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_20 GBV_ILN_21 GBV_ILN_23 GBV_ILN_30 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_100 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_4046 GBV_ILN_4305 GBV_ILN_4323 AR 42 2007 15 17 04 6139-6147 |
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10.1007/s10853-006-0982-y doi (DE-627)OLC2046329104 (DE-He213)s10853-006-0982-y-p DE-627 ger DE-627 rakwb eng 670 VZ Mack, Julia J. verfasserin aut Magnetically actuable polymer nanocomposites for bioengineering applications 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2007 Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. Composite Film Magnetic Force Field Gradient Magnetic Field Gradient IEC6 Cell Cox, Brian N. aut Lee, Min aut Dunn, James C. Y. aut Wu, Benjamin W. aut Enthalten in Journal of materials science Kluwer Academic Publishers-Plenum Publishers, 1966 42(2007), 15 vom: 17. Apr., Seite 6139-6147 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:42 year:2007 number:15 day:17 month:04 pages:6139-6147 https://doi.org/10.1007/s10853-006-0982-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_20 GBV_ILN_21 GBV_ILN_23 GBV_ILN_30 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_100 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_4046 GBV_ILN_4305 GBV_ILN_4323 AR 42 2007 15 17 04 6139-6147 |
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10.1007/s10853-006-0982-y doi (DE-627)OLC2046329104 (DE-He213)s10853-006-0982-y-p DE-627 ger DE-627 rakwb eng 670 VZ Mack, Julia J. verfasserin aut Magnetically actuable polymer nanocomposites for bioengineering applications 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2007 Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. Composite Film Magnetic Force Field Gradient Magnetic Field Gradient IEC6 Cell Cox, Brian N. aut Lee, Min aut Dunn, James C. Y. aut Wu, Benjamin W. aut Enthalten in Journal of materials science Kluwer Academic Publishers-Plenum Publishers, 1966 42(2007), 15 vom: 17. Apr., Seite 6139-6147 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:42 year:2007 number:15 day:17 month:04 pages:6139-6147 https://doi.org/10.1007/s10853-006-0982-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_20 GBV_ILN_21 GBV_ILN_23 GBV_ILN_30 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_100 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_4046 GBV_ILN_4305 GBV_ILN_4323 AR 42 2007 15 17 04 6139-6147 |
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Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. © Springer Science+Business Media, LLC 2007 |
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Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. © Springer Science+Business Media, LLC 2007 |
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Abstract Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly in vitro. © Springer Science+Business Media, LLC 2007 |
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