Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens

Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoact...
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Autor*in:	Rickman, Jessica [verfasserIn] Tronci, Giuseppe Liang, He Russell, Stephen J.

Format:	Artikel
Sprache:	Englisch

Erschienen:	2019

Anmerkung:	© The Author(s) 2019

Übergeordnetes Werk:	Enthalten in: Journal of materials science - Springer US, 1966, 54(2019), 14 vom: 16. Apr., Seite 10529-10547
Übergeordnetes Werk:	volume:54 ; year:2019 ; number:14 ; day:16 ; month:04 ; pages:10529-10547

Links:	Volltext

DOI / URN:	10.1007/s10853-019-03498-5

Katalog-ID:	OLC2046449851

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520			\|a Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications.
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allfields	10.1007/s10853-019-03498-5 doi (DE-627)OLC2046449851 (DE-He213)s10853-019-03498-5-p DE-627 ger DE-627 rakwb eng 670 VZ Rickman, Jessica verfasserin (orcid)0000-0001-5882-4983 aut Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens 2019 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2019 Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. Tronci, Giuseppe (orcid)0000-0002-9426-4220 aut Liang, He (orcid)0000-0002-7361-4690 aut Russell, Stephen J. (orcid)0000-0002-6238-0606 aut Enthalten in Journal of materials science Springer US, 1966 54(2019), 14 vom: 16. Apr., Seite 10529-10547 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:54 year:2019 number:14 day:16 month:04 pages:10529-10547 https://doi.org/10.1007/s10853-019-03498-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_70 GBV_ILN_2004 AR 54 2019 14 16 04 10529-10547
spelling	10.1007/s10853-019-03498-5 doi (DE-627)OLC2046449851 (DE-He213)s10853-019-03498-5-p DE-627 ger DE-627 rakwb eng 670 VZ Rickman, Jessica verfasserin (orcid)0000-0001-5882-4983 aut Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens 2019 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2019 Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. Tronci, Giuseppe (orcid)0000-0002-9426-4220 aut Liang, He (orcid)0000-0002-7361-4690 aut Russell, Stephen J. (orcid)0000-0002-6238-0606 aut Enthalten in Journal of materials science Springer US, 1966 54(2019), 14 vom: 16. Apr., Seite 10529-10547 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:54 year:2019 number:14 day:16 month:04 pages:10529-10547 https://doi.org/10.1007/s10853-019-03498-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_70 GBV_ILN_2004 AR 54 2019 14 16 04 10529-10547
allfields_unstemmed	10.1007/s10853-019-03498-5 doi (DE-627)OLC2046449851 (DE-He213)s10853-019-03498-5-p DE-627 ger DE-627 rakwb eng 670 VZ Rickman, Jessica verfasserin (orcid)0000-0001-5882-4983 aut Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens 2019 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2019 Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. Tronci, Giuseppe (orcid)0000-0002-9426-4220 aut Liang, He (orcid)0000-0002-7361-4690 aut Russell, Stephen J. (orcid)0000-0002-6238-0606 aut Enthalten in Journal of materials science Springer US, 1966 54(2019), 14 vom: 16. Apr., Seite 10529-10547 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:54 year:2019 number:14 day:16 month:04 pages:10529-10547 https://doi.org/10.1007/s10853-019-03498-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_70 GBV_ILN_2004 AR 54 2019 14 16 04 10529-10547
allfieldsGer	10.1007/s10853-019-03498-5 doi (DE-627)OLC2046449851 (DE-He213)s10853-019-03498-5-p DE-627 ger DE-627 rakwb eng 670 VZ Rickman, Jessica verfasserin (orcid)0000-0001-5882-4983 aut Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens 2019 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2019 Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. Tronci, Giuseppe (orcid)0000-0002-9426-4220 aut Liang, He (orcid)0000-0002-7361-4690 aut Russell, Stephen J. (orcid)0000-0002-6238-0606 aut Enthalten in Journal of materials science Springer US, 1966 54(2019), 14 vom: 16. Apr., Seite 10529-10547 (DE-627)129546372 (DE-600)218324-9 (DE-576)014996774 0022-2461 nnns volume:54 year:2019 number:14 day:16 month:04 pages:10529-10547 https://doi.org/10.1007/s10853-019-03498-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_70 GBV_ILN_2004 AR 54 2019 14 16 04 10529-10547
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title_auth	Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens
abstract	Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. © The Author(s) 2019
abstractGer	Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. © The Author(s) 2019
abstract_unstemmed	Abstract Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customisation. However, mechanically competent, long-lasting filaments are still hard to realise with current photoactive, e.g. methacrylated, gelatin systems due to inherent spinning instability and restricted coagulation capability. To explore this challenge, we present a multiscale approach combining the synthesis of 4-vinylbenzyl chloride (4VBC)-functionalised gelatin (Gel-4VBC) with a voltage-free spinning and UV-curing process so that biopolymer networks in the form of either individual fibres or nonwovens could be successfully manufactured. In comparison with state-of-the-art methacrylated gelatin, the mechanical properties of UV-cured Gel-4VBC fibres were readily modulated by adjustment of coagulation conditions, so that an ultimate tensile strength and strain at break of 25 ± 4–74 ± 3 MPa and 1.7 ± 0.3–8.6 ± 0.5% were measured, respectively. The sequential functionalisation/spinning route proved to be highly scalable, so that one-step spun-laid formation of fibroblast-friendly nonwoven fabrics was successfully demonstrated with wet-spun Gel-4VBC fibres. The presented approach could be exploited to generate a library of gelatin building blocks tuneable from the molecular to the macroscopic level to deliver computer-controlled extrusion of fibres and nonwovens according to defined clinical applications. © The Author(s) 2019
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC GBV_ILN_70 GBV_ILN_2004
container_issue	14
title_short	Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens
url	https://doi.org/10.1007/s10853-019-03498-5
remote_bool	false
author2	Tronci, Giuseppe Liang, He Russell, Stephen J.
author2Str	Tronci, Giuseppe Liang, He Russell, Stephen J.
ppnlink	129546372
mediatype_str_mv	n
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s10853-019-03498-5
up_date	2024-07-04T05:08:08.699Z
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