Analytical study on irradiated methylxanthine derivatives
Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Marciniec, Barbara [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of thermal analysis and calorimetry - Springer Netherlands, 1998, 111(2012), 3 vom: 09. Nov., Seite 2165-2170 |
|---|---|
| Übergeordnetes Werk: |
volume:111 ; year:2012 ; number:3 ; day:09 ; month:11 ; pages:2165-2170 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10973-012-2774-8 |
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OLC2049819153 |
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| 520 | |a Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. | ||
| 650 | 4 | |a Radiation sterilization | |
| 650 | 4 | |a Caffeine | |
| 650 | 4 | |a Theophylline | |
| 650 | 4 | |a Theobromine | |
| 700 | 1 | |a Stawny, Maciej |4 aut | |
| 700 | 1 | |a Olszewski, Karol |4 aut | |
| 700 | 1 | |a Kozak, Maciej |4 aut | |
| 700 | 1 | |a Naskrent, Marek |4 aut | |
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10.1007/s10973-012-2774-8 doi (DE-627)OLC2049819153 (DE-He213)s10973-012-2774-8-p DE-627 ger DE-627 rakwb eng 660 VZ Marciniec, Barbara verfasserin aut Analytical study on irradiated methylxanthine derivatives 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2012 Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. Radiation sterilization Caffeine Theophylline Theobromine Stawny, Maciej aut Olszewski, Karol aut Kozak, Maciej aut Naskrent, Marek aut Enthalten in Journal of thermal analysis and calorimetry Springer Netherlands, 1998 111(2012), 3 vom: 09. Nov., Seite 2165-2170 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:111 year:2012 number:3 day:09 month:11 pages:2165-2170 https://doi.org/10.1007/s10973-012-2774-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 AR 111 2012 3 09 11 2165-2170 |
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10.1007/s10973-012-2774-8 doi (DE-627)OLC2049819153 (DE-He213)s10973-012-2774-8-p DE-627 ger DE-627 rakwb eng 660 VZ Marciniec, Barbara verfasserin aut Analytical study on irradiated methylxanthine derivatives 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2012 Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. Radiation sterilization Caffeine Theophylline Theobromine Stawny, Maciej aut Olszewski, Karol aut Kozak, Maciej aut Naskrent, Marek aut Enthalten in Journal of thermal analysis and calorimetry Springer Netherlands, 1998 111(2012), 3 vom: 09. Nov., Seite 2165-2170 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:111 year:2012 number:3 day:09 month:11 pages:2165-2170 https://doi.org/10.1007/s10973-012-2774-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 AR 111 2012 3 09 11 2165-2170 |
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10.1007/s10973-012-2774-8 doi (DE-627)OLC2049819153 (DE-He213)s10973-012-2774-8-p DE-627 ger DE-627 rakwb eng 660 VZ Marciniec, Barbara verfasserin aut Analytical study on irradiated methylxanthine derivatives 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2012 Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. Radiation sterilization Caffeine Theophylline Theobromine Stawny, Maciej aut Olszewski, Karol aut Kozak, Maciej aut Naskrent, Marek aut Enthalten in Journal of thermal analysis and calorimetry Springer Netherlands, 1998 111(2012), 3 vom: 09. Nov., Seite 2165-2170 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:111 year:2012 number:3 day:09 month:11 pages:2165-2170 https://doi.org/10.1007/s10973-012-2774-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 AR 111 2012 3 09 11 2165-2170 |
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10.1007/s10973-012-2774-8 doi (DE-627)OLC2049819153 (DE-He213)s10973-012-2774-8-p DE-627 ger DE-627 rakwb eng 660 VZ Marciniec, Barbara verfasserin aut Analytical study on irradiated methylxanthine derivatives 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2012 Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. Radiation sterilization Caffeine Theophylline Theobromine Stawny, Maciej aut Olszewski, Karol aut Kozak, Maciej aut Naskrent, Marek aut Enthalten in Journal of thermal analysis and calorimetry Springer Netherlands, 1998 111(2012), 3 vom: 09. Nov., Seite 2165-2170 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:111 year:2012 number:3 day:09 month:11 pages:2165-2170 https://doi.org/10.1007/s10973-012-2774-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 AR 111 2012 3 09 11 2165-2170 |
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10.1007/s10973-012-2774-8 doi (DE-627)OLC2049819153 (DE-He213)s10973-012-2774-8-p DE-627 ger DE-627 rakwb eng 660 VZ Marciniec, Barbara verfasserin aut Analytical study on irradiated methylxanthine derivatives 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2012 Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. Radiation sterilization Caffeine Theophylline Theobromine Stawny, Maciej aut Olszewski, Karol aut Kozak, Maciej aut Naskrent, Marek aut Enthalten in Journal of thermal analysis and calorimetry Springer Netherlands, 1998 111(2012), 3 vom: 09. Nov., Seite 2165-2170 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:111 year:2012 number:3 day:09 month:11 pages:2165-2170 https://doi.org/10.1007/s10973-012-2774-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 AR 111 2012 3 09 11 2165-2170 |
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Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. © The Author(s) 2012 |
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Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. © The Author(s) 2012 |
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Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation. © The Author(s) 2012 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2049819153</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503165842.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200820s2012 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10973-012-2774-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2049819153</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)s10973-012-2774-8-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">660</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Marciniec, Barbara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Analytical study on irradiated methylxanthine derivatives</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2012</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The effect of ionising radiation on the physico-chemical properties of three derivatives of xanthine: caffeine, theophylline and theobromine, has been studied. The above-drugs in the solid phase have been irradiated with E-beam of the energy 9.96 MeV with the doses varied from 25 to 400 kGy. The effects of the irradiation have been examined by differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR) and high-performance liquid chromatography (HPLC). The results have shown that the methylxanthine derivatives studied are resistant to ionising irradiation in the doses usually used for sterilisation (<50 kGy), which means that they are relatively radiochemically stable and can be sterilised by irradiation.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Radiation sterilization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Caffeine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Theophylline</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Theobromine</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stawny, Maciej</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Olszewski, Karol</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kozak, Maciej</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naskrent, Marek</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of thermal analysis and calorimetry</subfield><subfield code="d">Springer Netherlands, 1998</subfield><subfield code="g">111(2012), 3 vom: 09. Nov., Seite 2165-2170</subfield><subfield code="w">(DE-627)244148767</subfield><subfield code="w">(DE-600)1429493-X</subfield><subfield code="w">(DE-576)066397693</subfield><subfield code="x">1388-6150</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:111</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:3</subfield><subfield code="g">day:09</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:2165-2170</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/s10973-012-2774-8</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">111</subfield><subfield code="j">2012</subfield><subfield code="e">3</subfield><subfield code="b">09</subfield><subfield code="c">11</subfield><subfield code="h">2165-2170</subfield></datafield></record></collection>
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