Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity
Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Jinghua [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of inorganic and organometallic polymers and materials - Springer US, 1991, 23(2012), 1 vom: 21. Sept., Seite 119-125 |
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| Übergeordnetes Werk: |
volume:23 ; year:2012 ; number:1 ; day:21 ; month:09 ; pages:119-125 |
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| DOI / URN: |
10.1007/s10904-012-9752-2 |
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| 520 | |a Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). | ||
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| 650 | 4 | |a Groove binding | |
| 650 | 4 | |a Cytotoxicity | |
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| 700 | 1 | |a Higuchi, Masayoshi |4 aut | |
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10.1007/s10904-012-9752-2 doi (DE-627)OLC206151250X (DE-He213)s10904-012-9752-2-p DE-627 ger DE-627 rakwb eng 660 VZ Li, Jinghua verfasserin aut Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2012 Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). Metallo-supramolecular polymer DNA Electrostatic interaction Groove binding Cytotoxicity Murakami, Tatsuya aut Higuchi, Masayoshi aut Enthalten in Journal of inorganic and organometallic polymers and materials Springer US, 1991 23(2012), 1 vom: 21. Sept., Seite 119-125 (DE-627)130968625 (DE-600)1069621-0 (DE-576)029153867 1574-1443 nnns volume:23 year:2012 number:1 day:21 month:09 pages:119-125 https://doi.org/10.1007/s10904-012-9752-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 AR 23 2012 1 21 09 119-125 |
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10.1007/s10904-012-9752-2 doi (DE-627)OLC206151250X (DE-He213)s10904-012-9752-2-p DE-627 ger DE-627 rakwb eng 660 VZ Li, Jinghua verfasserin aut Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2012 Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). Metallo-supramolecular polymer DNA Electrostatic interaction Groove binding Cytotoxicity Murakami, Tatsuya aut Higuchi, Masayoshi aut Enthalten in Journal of inorganic and organometallic polymers and materials Springer US, 1991 23(2012), 1 vom: 21. Sept., Seite 119-125 (DE-627)130968625 (DE-600)1069621-0 (DE-576)029153867 1574-1443 nnns volume:23 year:2012 number:1 day:21 month:09 pages:119-125 https://doi.org/10.1007/s10904-012-9752-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 AR 23 2012 1 21 09 119-125 |
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10.1007/s10904-012-9752-2 doi (DE-627)OLC206151250X (DE-He213)s10904-012-9752-2-p DE-627 ger DE-627 rakwb eng 660 VZ Li, Jinghua verfasserin aut Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2012 Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). Metallo-supramolecular polymer DNA Electrostatic interaction Groove binding Cytotoxicity Murakami, Tatsuya aut Higuchi, Masayoshi aut Enthalten in Journal of inorganic and organometallic polymers and materials Springer US, 1991 23(2012), 1 vom: 21. Sept., Seite 119-125 (DE-627)130968625 (DE-600)1069621-0 (DE-576)029153867 1574-1443 nnns volume:23 year:2012 number:1 day:21 month:09 pages:119-125 https://doi.org/10.1007/s10904-012-9752-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 AR 23 2012 1 21 09 119-125 |
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10.1007/s10904-012-9752-2 doi (DE-627)OLC206151250X (DE-He213)s10904-012-9752-2-p DE-627 ger DE-627 rakwb eng 660 VZ Li, Jinghua verfasserin aut Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2012 Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). Metallo-supramolecular polymer DNA Electrostatic interaction Groove binding Cytotoxicity Murakami, Tatsuya aut Higuchi, Masayoshi aut Enthalten in Journal of inorganic and organometallic polymers and materials Springer US, 1991 23(2012), 1 vom: 21. Sept., Seite 119-125 (DE-627)130968625 (DE-600)1069621-0 (DE-576)029153867 1574-1443 nnns volume:23 year:2012 number:1 day:21 month:09 pages:119-125 https://doi.org/10.1007/s10904-012-9752-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 AR 23 2012 1 21 09 119-125 |
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10.1007/s10904-012-9752-2 doi (DE-627)OLC206151250X (DE-He213)s10904-012-9752-2-p DE-627 ger DE-627 rakwb eng 660 VZ Li, Jinghua verfasserin aut Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity 2012 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2012 Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). Metallo-supramolecular polymer DNA Electrostatic interaction Groove binding Cytotoxicity Murakami, Tatsuya aut Higuchi, Masayoshi aut Enthalten in Journal of inorganic and organometallic polymers and materials Springer US, 1991 23(2012), 1 vom: 21. Sept., Seite 119-125 (DE-627)130968625 (DE-600)1069621-0 (DE-576)029153867 1574-1443 nnns volume:23 year:2012 number:1 day:21 month:09 pages:119-125 https://doi.org/10.1007/s10904-012-9752-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 AR 23 2012 1 21 09 119-125 |
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Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity |
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Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). © Springer Science+Business Media, LLC 2012 |
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Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). © Springer Science+Business Media, LLC 2012 |
| abstract_unstemmed |
Abstract Metallo-supramolecular polymers (RuL1, RuL2, RuL3, FeL3, and FeL4) prepared by complexation of bis(terpyridine) derivatives with $ Ru^{2+} $ or $ Fe^{2+} $ ions with octahedral coordination structures showed high binding ability to several DNAs (calf thymus DNA, herring sperm DNA, [poly(dA-dT)]2, and [poly(dG-dC)]2), which were revealed by UV–Vis absorption titration experiments. The electrostatic interactions between the metal cations of the polymers and phosphate anions of DNA led to formation of conjugate structure. The binding constant observed reached 3.7 × $ 10^{7} $ $ M^{−1} $, which is the highest among values reported for metal complexes to date. Based on a long strand structure of the polymer, groove binding is most possible binding mode. Cell viability experiments showed that RuL3 and FeL3 displayed highly statistical significance (**p<0.01) to human non small cell lung cancer cell lines (NCI-H460). © Springer Science+Business Media, LLC 2012 |
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Metallo-supramolecular Polymers: Versatile DNA Binding and Their Cytotoxicity |
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https://doi.org/10.1007/s10904-012-9752-2 |
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Murakami, Tatsuya Higuchi, Masayoshi |
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