Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions

Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silic...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ohura, K. [verfasserIn] Nakamura, T. Yamamuro, T. Ebisawa, Y. Kokubo, T. Kotoura, Y. Oka, M.

Format:	Artikel
Sprache:	Englisch

Erschienen:	1992

Schlagwörter:	SiO2 Silicate Al2O3 Fe2O3 P2O5

Anmerkung:	© Chapman & Hall 1992

Übergeordnetes Werk:	Enthalten in: Journal of materials science / Materials in medicine - Kluwer Academic Publishers, 1990, 3(1992), 2 vom: März, Seite 95-100
Übergeordnetes Werk:	volume:3 ; year:1992 ; number:2 ; month:03 ; pages:95-100

Links:	Volltext

DOI / URN:	10.1007/BF00705275

Katalog-ID:	OLC2066781622

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520			\|a Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks.
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700	1		\|a Yamamuro, T. \|4 aut
700	1		\|a Ebisawa, Y. \|4 aut
700	1		\|a Kokubo, T. \|4 aut
700	1		\|a Kotoura, Y. \|4 aut
700	1		\|a Oka, M. \|4 aut
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hierarchy_sort_str	1992
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allfields	10.1007/BF00705275 doi (DE-627)OLC2066781622 (DE-He213)BF00705275-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ohura, K. verfasserin aut Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions 1992 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Chapman & Hall 1992 Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. SiO2 Silicate Al2O3 Fe2O3 P2O5 Nakamura, T. aut Yamamuro, T. aut Ebisawa, Y. aut Kokubo, T. aut Kotoura, Y. aut Oka, M. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 3(1992), 2 vom: März, Seite 95-100 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:3 year:1992 number:2 month:03 pages:95-100 https://doi.org/10.1007/BF00705275 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 GBV_ILN_4700 AR 3 1992 2 03 95-100
spelling	10.1007/BF00705275 doi (DE-627)OLC2066781622 (DE-He213)BF00705275-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ohura, K. verfasserin aut Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions 1992 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Chapman & Hall 1992 Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. SiO2 Silicate Al2O3 Fe2O3 P2O5 Nakamura, T. aut Yamamuro, T. aut Ebisawa, Y. aut Kokubo, T. aut Kotoura, Y. aut Oka, M. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 3(1992), 2 vom: März, Seite 95-100 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:3 year:1992 number:2 month:03 pages:95-100 https://doi.org/10.1007/BF00705275 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 GBV_ILN_4700 AR 3 1992 2 03 95-100
allfields_unstemmed	10.1007/BF00705275 doi (DE-627)OLC2066781622 (DE-He213)BF00705275-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ohura, K. verfasserin aut Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions 1992 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Chapman & Hall 1992 Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. SiO2 Silicate Al2O3 Fe2O3 P2O5 Nakamura, T. aut Yamamuro, T. aut Ebisawa, Y. aut Kokubo, T. aut Kotoura, Y. aut Oka, M. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 3(1992), 2 vom: März, Seite 95-100 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:3 year:1992 number:2 month:03 pages:95-100 https://doi.org/10.1007/BF00705275 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 GBV_ILN_4700 AR 3 1992 2 03 95-100
allfieldsGer	10.1007/BF00705275 doi (DE-627)OLC2066781622 (DE-He213)BF00705275-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ohura, K. verfasserin aut Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions 1992 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Chapman & Hall 1992 Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. SiO2 Silicate Al2O3 Fe2O3 P2O5 Nakamura, T. aut Yamamuro, T. aut Ebisawa, Y. aut Kokubo, T. aut Kotoura, Y. aut Oka, M. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 3(1992), 2 vom: März, Seite 95-100 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:3 year:1992 number:2 month:03 pages:95-100 https://doi.org/10.1007/BF00705275 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 GBV_ILN_4700 AR 3 1992 2 03 95-100
allfieldsSound	10.1007/BF00705275 doi (DE-627)OLC2066781622 (DE-He213)BF00705275-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ohura, K. verfasserin aut Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions 1992 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Chapman & Hall 1992 Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. SiO2 Silicate Al2O3 Fe2O3 P2O5 Nakamura, T. aut Yamamuro, T. aut Ebisawa, Y. aut Kokubo, T. aut Kotoura, Y. aut Oka, M. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 3(1992), 2 vom: März, Seite 95-100 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:3 year:1992 number:2 month:03 pages:95-100 https://doi.org/10.1007/BF00705275 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 GBV_ILN_4700 AR 3 1992 2 03 95-100
language	English
source	Enthalten in Journal of materials science / Materials in medicine 3(1992), 2 vom: März, Seite 95-100 volume:3 year:1992 number:2 month:03 pages:95-100
sourceStr	Enthalten in Journal of materials science / Materials in medicine 3(1992), 2 vom: März, Seite 95-100 volume:3 year:1992 number:2 month:03 pages:95-100
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SiO2 Silicate Al2O3 Fe2O3 P2O5
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container_title	Journal of materials science / Materials in medicine
authorswithroles_txt_mv	Ohura, K. @@aut@@ Nakamura, T. @@aut@@ Yamamuro, T. @@aut@@ Ebisawa, Y. @@aut@@ Kokubo, T. @@aut@@ Kotoura, Y. @@aut@@ Oka, M. @@aut@@
publishDateDaySort_date	1992-03-01T00:00:00Z
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author	Ohura, K.
spellingShingle	Ohura, K. ddc 610 misc SiO2 misc Silicate misc Al2O3 misc Fe2O3 misc P2O5 Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions
authorStr	Ohura, K.
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topic_title	610 670 VZ Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions SiO2 Silicate Al2O3 Fe2O3 P2O5
topic	ddc 610 misc SiO2 misc Silicate misc Al2O3 misc Fe2O3 misc P2O5
topic_unstemmed	ddc 610 misc SiO2 misc Silicate misc Al2O3 misc Fe2O3 misc P2O5
topic_browse	ddc 610 misc SiO2 misc Silicate misc Al2O3 misc Fe2O3 misc P2O5
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title	Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions
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title_full	Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions
author_sort	Ohura, K.
journal	Journal of materials science / Materials in medicine
journalStr	Journal of materials science / Materials in medicine
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author_browse	Ohura, K. Nakamura, T. Yamamuro, T. Ebisawa, Y. Kokubo, T. Kotoura, Y. Oka, M.
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class	610 670 VZ
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author-letter	Ohura, K.
doi_str_mv	10.1007/BF00705275
dewey-full	610 670
title_sort	bioactivity of cao·$ sio_{2} $ glasses added with various ions
title_auth	Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions
abstract	Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. © Chapman & Hall 1992
abstractGer	Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. © Chapman & Hall 1992
abstract_unstemmed	Abstract The purpose of this investigation was to study the fundamental compositional dependence of bioactivity for bioactive glasses by adding a third component such as $ Na_{2} $O, $ B_{2} $$ O_{3} $, $ Al_{2} $$ O_{3} $, $ Fe_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ or $ F^{−} $ to binary calcium silicate glass. Rectangular specimens of these six kinds of calcium silicate glasses containing each 3 wt ratio third component were implanted into the tibias of mature rabbits for 8 or 25 weeks. Contact microradiograms and SEM-EPMA showed that all glasses, except for $ Fe_{2} $$ O_{3} $-containing glass, formed a Ca, P-rich layer in combination with a Si-rich layer on their surfaces within 8 weeks. The other four kinds of glass except that containing $ Al_{2} $$ O_{3} $ became attached to bone through these layers within 8 weeks, and even $ Al_{2} $$ O_{3} $-containing glass became attached to bone by 25 weeks. $ Fe_{2} $$ O_{3} $-containing glass did not form these layers, nor did it attach to bone even at 25 weeks. A detachment test, performed 8 weeks after implantation, showed that only glasses containing $ B_{2} $$ O_{3} $, $ P_{2} $$ O_{5} $ and $ F^{−} $ bonded tightly with bone. Glass containing $ B_{2} $$ O_{3} $ maintained a tight bond at 25 weeks, but the other two kinds of glass showed decreased loads at 25 weeks. © Chapman & Hall 1992
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title_short	Bioactivity of CaO·$ SiO_{2} $ glasses added with various ions
url	https://doi.org/10.1007/BF00705275
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author2	Nakamura, T. Yamamuro, T. Ebisawa, Y. Kokubo, T. Kotoura, Y. Oka, M.
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