The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system
Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have be...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Franks, K. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2002 |
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| Schlagwörter: |
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| Anmerkung: |
© Kluwer Academic Publishers 2002 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science / Materials in medicine - Kluwer Academic Publishers, 1990, 13(2002), 6 vom: Juni, Seite 549-556 |
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| Übergeordnetes Werk: |
volume:13 ; year:2002 ; number:6 ; month:06 ; pages:549-556 |
| Links: |
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| DOI / URN: |
10.1023/A:1015122709576 |
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OLC206679533X |
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| 520 | |a Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. | ||
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10.1023/A:1015122709576 doi (DE-627)OLC206679533X (DE-He213)A:1015122709576-p DE-627 ger DE-627 rakwb eng 610 670 VZ Franks, K. verfasserin aut The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Kluwer Academic Publishers 2002 Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. Na2O MG63 Cell Phosphate Glass Soluble Phosphate Glass System Salih, V. aut Knowles, J. C. aut Olsen, I. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 13(2002), 6 vom: Juni, Seite 549-556 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:13 year:2002 number:6 month:06 pages:549-556 https://doi.org/10.1023/A:1015122709576 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 AR 13 2002 6 06 549-556 |
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10.1023/A:1015122709576 doi (DE-627)OLC206679533X (DE-He213)A:1015122709576-p DE-627 ger DE-627 rakwb eng 610 670 VZ Franks, K. verfasserin aut The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Kluwer Academic Publishers 2002 Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. Na2O MG63 Cell Phosphate Glass Soluble Phosphate Glass System Salih, V. aut Knowles, J. C. aut Olsen, I. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 13(2002), 6 vom: Juni, Seite 549-556 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:13 year:2002 number:6 month:06 pages:549-556 https://doi.org/10.1023/A:1015122709576 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 AR 13 2002 6 06 549-556 |
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10.1023/A:1015122709576 doi (DE-627)OLC206679533X (DE-He213)A:1015122709576-p DE-627 ger DE-627 rakwb eng 610 670 VZ Franks, K. verfasserin aut The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Kluwer Academic Publishers 2002 Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. Na2O MG63 Cell Phosphate Glass Soluble Phosphate Glass System Salih, V. aut Knowles, J. C. aut Olsen, I. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 13(2002), 6 vom: Juni, Seite 549-556 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:13 year:2002 number:6 month:06 pages:549-556 https://doi.org/10.1023/A:1015122709576 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 AR 13 2002 6 06 549-556 |
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10.1023/A:1015122709576 doi (DE-627)OLC206679533X (DE-He213)A:1015122709576-p DE-627 ger DE-627 rakwb eng 610 670 VZ Franks, K. verfasserin aut The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Kluwer Academic Publishers 2002 Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. Na2O MG63 Cell Phosphate Glass Soluble Phosphate Glass System Salih, V. aut Knowles, J. C. aut Olsen, I. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 13(2002), 6 vom: Juni, Seite 549-556 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:13 year:2002 number:6 month:06 pages:549-556 https://doi.org/10.1023/A:1015122709576 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 AR 13 2002 6 06 549-556 |
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10.1023/A:1015122709576 doi (DE-627)OLC206679533X (DE-He213)A:1015122709576-p DE-627 ger DE-627 rakwb eng 610 670 VZ Franks, K. verfasserin aut The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Kluwer Academic Publishers 2002 Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. Na2O MG63 Cell Phosphate Glass Soluble Phosphate Glass System Salih, V. aut Knowles, J. C. aut Olsen, I. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 13(2002), 6 vom: Juni, Seite 549-556 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:13 year:2002 number:6 month:06 pages:549-556 https://doi.org/10.1023/A:1015122709576 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_65 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4323 AR 13 2002 6 06 549-556 |
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The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system |
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Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. © Kluwer Academic Publishers 2002 |
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Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. © Kluwer Academic Publishers 2002 |
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Abstract This paper presents a systematic study of the MgO–CaO–$ Na_{2} $O–$ P_{2} $$ O_{5} $ glass system, which has great potential to be used as temporary hard and soft tissue implant materials. An overall study of solubility behavior of ternary and quaternary-based phosphate glass system have been carried out in order to understand the out-leaching progress of different ions and to determine their effect on cell proliferation. Originally, soluble phosphate based glasses within the ternary glass system of $ Na_{2} $O–CaO–$ P_{2} $$ O_{5} $ have been developed to create a simple baseline system. This paper, however, presents the development of this system by introducing magnesium oxide as a partial calcium oxide substitute and solubility behaviors as well as cell studies have been carried out to check the effect on magnesium ions. Glasses have been prepared via standard glass melting techniques and their solubility behavior has been tested in distilled water via simple weight loss, pH and ion measurements. The way the glasses dissolve is an inverse exponential behavior which is mirrored by the calcium ion release. Other ions show a less exponential behavior. The MTT test has been used to check preliminary in vitro studies on a human MG63 cell line and the result indicates that cell proliferation is increased for glasses with minimal CaO substitution. © Kluwer Academic Publishers 2002 |
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