The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep
Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor si...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ekholm, M. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science + Business Media, Inc. 2006 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science / Materials in medicine - Kluwer Academic Publishers, 1990, 17(2006), 2 vom: Feb., Seite 139-145 |
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| Übergeordnetes Werk: |
volume:17 ; year:2006 ; number:2 ; month:02 ; pages:139-145 |
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| DOI / URN: |
10.1007/s10856-006-6817-1 |
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OLC2066801615 |
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| 520 | |a Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. | ||
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10.1007/s10856-006-6817-1 doi (DE-627)OLC2066801615 (DE-He213)s10856-006-6817-1-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ekholm, M. verfasserin aut The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep 2006 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2006 Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. Bone Graft Bone Defect Control Site Critical Size Defect Size Hietanen, J. aut Tulamo, R.-M. aut Muhonen, J. aut Lindqvist, C. aut Kellomäki, M. aut Suuronen, R. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 17(2006), 2 vom: Feb., Seite 139-145 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:17 year:2006 number:2 month:02 pages:139-145 https://doi.org/10.1007/s10856-006-6817-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 17 2006 2 02 139-145 |
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10.1007/s10856-006-6817-1 doi (DE-627)OLC2066801615 (DE-He213)s10856-006-6817-1-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ekholm, M. verfasserin aut The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep 2006 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2006 Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. Bone Graft Bone Defect Control Site Critical Size Defect Size Hietanen, J. aut Tulamo, R.-M. aut Muhonen, J. aut Lindqvist, C. aut Kellomäki, M. aut Suuronen, R. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 17(2006), 2 vom: Feb., Seite 139-145 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:17 year:2006 number:2 month:02 pages:139-145 https://doi.org/10.1007/s10856-006-6817-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 17 2006 2 02 139-145 |
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10.1007/s10856-006-6817-1 doi (DE-627)OLC2066801615 (DE-He213)s10856-006-6817-1-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ekholm, M. verfasserin aut The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep 2006 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2006 Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. Bone Graft Bone Defect Control Site Critical Size Defect Size Hietanen, J. aut Tulamo, R.-M. aut Muhonen, J. aut Lindqvist, C. aut Kellomäki, M. aut Suuronen, R. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 17(2006), 2 vom: Feb., Seite 139-145 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:17 year:2006 number:2 month:02 pages:139-145 https://doi.org/10.1007/s10856-006-6817-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 17 2006 2 02 139-145 |
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10.1007/s10856-006-6817-1 doi (DE-627)OLC2066801615 (DE-He213)s10856-006-6817-1-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ekholm, M. verfasserin aut The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep 2006 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2006 Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. Bone Graft Bone Defect Control Site Critical Size Defect Size Hietanen, J. aut Tulamo, R.-M. aut Muhonen, J. aut Lindqvist, C. aut Kellomäki, M. aut Suuronen, R. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 17(2006), 2 vom: Feb., Seite 139-145 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:17 year:2006 number:2 month:02 pages:139-145 https://doi.org/10.1007/s10856-006-6817-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 17 2006 2 02 139-145 |
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10.1007/s10856-006-6817-1 doi (DE-627)OLC2066801615 (DE-He213)s10856-006-6817-1-p DE-627 ger DE-627 rakwb eng 610 670 VZ Ekholm, M. verfasserin aut The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep 2006 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2006 Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. Bone Graft Bone Defect Control Site Critical Size Defect Size Hietanen, J. aut Tulamo, R.-M. aut Muhonen, J. aut Lindqvist, C. aut Kellomäki, M. aut Suuronen, R. aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 17(2006), 2 vom: Feb., Seite 139-145 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:17 year:2006 number:2 month:02 pages:139-145 https://doi.org/10.1007/s10856-006-6817-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 17 2006 2 02 139-145 |
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the copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep |
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The copolymer of ε-caprolactone-lactide and tricalcium phosphate does not enhance bone growth in mandibular defect of sheep |
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Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. © Springer Science + Business Media, Inc. 2006 |
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Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. © Springer Science + Business Media, Inc. 2006 |
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Abstract In the field of craniomaxillofacial and orthopaedic surgery there is a constant need for bone or bone substitute. At the present, the most effective way to enhance bone healing clinically is to use autogenous bone grafts. The problems associated with the use of these autografts are donor site morbidity, limited supply and need for a second operative site. Currently there are several different synthetic products commercially available in the market; nevertheless, none of them is ideal for filling bone defects. Therefore, search for new synthetic materials for bone replacement is necessary. A mixture of tricalcium phosphate (TCP) and ε-caprolactone-lactide copolymer P(ε -CL/DL-LA) was prepared and implanted in critical size mandibular bone defects in twelve sheep. Contralateral side was used as a control. Follow-up times for histological and radiological studies were 9, 14, 24 and 52 weeks. We found that the implanted material did not enhance bone formation compared to control site. We also confirmed that defect size was of critical size, since there was no complete healing of the control site either. The results do not encourage us to continue our studies with the mixture of TCP and P(ε-CL/DL-LA) as a filling material for bone defects. Therefore the search for the ideal material is still ongoing. © Springer Science + Business Media, Inc. 2006 |
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