Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture
Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hodde, Jason [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science + Business Media, LLC 2007 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science / Materials in medicine - Kluwer Academic Publishers, 1990, 18(2007), 4 vom: Apr., Seite 537-543 |
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| Übergeordnetes Werk: |
volume:18 ; year:2007 ; number:4 ; month:04 ; pages:537-543 |
| Links: |
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| DOI / URN: |
10.1007/s10856-007-2300-x |
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| Katalog-ID: |
OLC2066804029 |
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| 245 | 1 | 0 | |a Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture |
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| 520 | |a Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. | ||
| 650 | 4 | |a Hyaluronic Acid | |
| 650 | 4 | |a Ethylene Oxide | |
| 650 | 4 | |a Ethylene Oxide | |
| 650 | 4 | |a Small Intestine Submucosa | |
| 650 | 4 | |a Peracetic Acid | |
| 700 | 1 | |a Janis, Abram |4 aut | |
| 700 | 1 | |a Ernst, David |4 aut | |
| 700 | 1 | |a Zopf, David |4 aut | |
| 700 | 1 | |a Sherman, Debra |4 aut | |
| 700 | 1 | |a Johnson, Chad |4 aut | |
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10.1007/s10856-007-2300-x doi (DE-627)OLC2066804029 (DE-He213)s10856-007-2300-x-p DE-627 ger DE-627 rakwb eng 610 670 VZ Hodde, Jason verfasserin aut Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, LLC 2007 Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. Hyaluronic Acid Ethylene Oxide Ethylene Oxide Small Intestine Submucosa Peracetic Acid Janis, Abram aut Ernst, David aut Zopf, David aut Sherman, Debra aut Johnson, Chad aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 18(2007), 4 vom: Apr., Seite 537-543 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:18 year:2007 number:4 month:04 pages:537-543 https://doi.org/10.1007/s10856-007-2300-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 18 2007 4 04 537-543 |
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10.1007/s10856-007-2300-x doi (DE-627)OLC2066804029 (DE-He213)s10856-007-2300-x-p DE-627 ger DE-627 rakwb eng 610 670 VZ Hodde, Jason verfasserin aut Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, LLC 2007 Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. Hyaluronic Acid Ethylene Oxide Ethylene Oxide Small Intestine Submucosa Peracetic Acid Janis, Abram aut Ernst, David aut Zopf, David aut Sherman, Debra aut Johnson, Chad aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 18(2007), 4 vom: Apr., Seite 537-543 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:18 year:2007 number:4 month:04 pages:537-543 https://doi.org/10.1007/s10856-007-2300-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 18 2007 4 04 537-543 |
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10.1007/s10856-007-2300-x doi (DE-627)OLC2066804029 (DE-He213)s10856-007-2300-x-p DE-627 ger DE-627 rakwb eng 610 670 VZ Hodde, Jason verfasserin aut Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, LLC 2007 Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. Hyaluronic Acid Ethylene Oxide Ethylene Oxide Small Intestine Submucosa Peracetic Acid Janis, Abram aut Ernst, David aut Zopf, David aut Sherman, Debra aut Johnson, Chad aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 18(2007), 4 vom: Apr., Seite 537-543 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:18 year:2007 number:4 month:04 pages:537-543 https://doi.org/10.1007/s10856-007-2300-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 18 2007 4 04 537-543 |
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10.1007/s10856-007-2300-x doi (DE-627)OLC2066804029 (DE-He213)s10856-007-2300-x-p DE-627 ger DE-627 rakwb eng 610 670 VZ Hodde, Jason verfasserin aut Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, LLC 2007 Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. Hyaluronic Acid Ethylene Oxide Ethylene Oxide Small Intestine Submucosa Peracetic Acid Janis, Abram aut Ernst, David aut Zopf, David aut Sherman, Debra aut Johnson, Chad aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 18(2007), 4 vom: Apr., Seite 537-543 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:18 year:2007 number:4 month:04 pages:537-543 https://doi.org/10.1007/s10856-007-2300-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 18 2007 4 04 537-543 |
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10.1007/s10856-007-2300-x doi (DE-627)OLC2066804029 (DE-He213)s10856-007-2300-x-p DE-627 ger DE-627 rakwb eng 610 670 VZ Hodde, Jason verfasserin aut Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture 2007 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, LLC 2007 Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. Hyaluronic Acid Ethylene Oxide Ethylene Oxide Small Intestine Submucosa Peracetic Acid Janis, Abram aut Ernst, David aut Zopf, David aut Sherman, Debra aut Johnson, Chad aut Enthalten in Journal of materials science / Materials in medicine Kluwer Academic Publishers, 1990 18(2007), 4 vom: Apr., Seite 537-543 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:18 year:2007 number:4 month:04 pages:537-543 https://doi.org/10.1007/s10856-007-2300-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_62 GBV_ILN_65 GBV_ILN_70 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 18 2007 4 04 537-543 |
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Enthalten in Journal of materials science / Materials in medicine 18(2007), 4 vom: Apr., Seite 537-543 volume:18 year:2007 number:4 month:04 pages:537-543 |
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Effects of sterilization on an extracellular matrix scaffold: Part I. Composition and matrix architecture |
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Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. © Springer Science + Business Media, LLC 2007 |
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Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. © Springer Science + Business Media, LLC 2007 |
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Abstract The impact of peracetic acid (PAA), lyophilization, and ethylene oxide (EO) sterilization on the composition and three dimensional matrix structure of small intestinal submucosa (SIS), a biologic scaffold used to stimulate the repair of damaged tissues and organs, was examined. Fibronectin and glycosaminoglycans are retained in SIS following oxidation by peracetic acid and alkylation using ethylene oxide gas. Significant amounts of FGF-2 are also retained, but VEGF is susceptible to the effects of PAA and is dramatically reduced following processing. Further, matrix oxidation, lyophilization, and sterilization with EO can be performed without irreversibly collapsing the three dimensional structure of the native SIS. These structural features and growth promoting extracellular matrix constituents are likely to be important variables underlying cellular attachment, infiltration and eventual incorporation of SIS into healing host tissues. © Springer Science + Business Media, LLC 2007 |
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