In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy
Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneou...
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Gespeichert in:
| Autor*in: |
Aghion, E. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC 2011 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science / Materials in medicine - Springer US, 1990, 23(2011), 3 vom: 22. Dez., Seite 805-812 |
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| Übergeordnetes Werk: |
volume:23 ; year:2011 ; number:3 ; day:22 ; month:12 ; pages:805-812 |
| Links: |
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| DOI / URN: |
10.1007/s10856-011-4536-8 |
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OLC2066818909 |
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| 520 | |a Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. | ||
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10.1007/s10856-011-4536-8 doi (DE-627)OLC2066818909 (DE-He213)s10856-011-4536-8-p DE-627 ger DE-627 rakwb eng 610 670 VZ Aghion, E. verfasserin aut In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy 2011 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2011 Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. Corrosion Rate Magnesium Alloy Control Alloy Weekly Body Weight Alloy Implant Levy, G. aut Ovadia, S. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 23(2011), 3 vom: 22. Dez., Seite 805-812 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:23 year:2011 number:3 day:22 month:12 pages:805-812 https://doi.org/10.1007/s10856-011-4536-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 23 2011 3 22 12 805-812 |
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10.1007/s10856-011-4536-8 doi (DE-627)OLC2066818909 (DE-He213)s10856-011-4536-8-p DE-627 ger DE-627 rakwb eng 610 670 VZ Aghion, E. verfasserin aut In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy 2011 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2011 Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. Corrosion Rate Magnesium Alloy Control Alloy Weekly Body Weight Alloy Implant Levy, G. aut Ovadia, S. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 23(2011), 3 vom: 22. Dez., Seite 805-812 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:23 year:2011 number:3 day:22 month:12 pages:805-812 https://doi.org/10.1007/s10856-011-4536-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 23 2011 3 22 12 805-812 |
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10.1007/s10856-011-4536-8 doi (DE-627)OLC2066818909 (DE-He213)s10856-011-4536-8-p DE-627 ger DE-627 rakwb eng 610 670 VZ Aghion, E. verfasserin aut In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy 2011 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2011 Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. Corrosion Rate Magnesium Alloy Control Alloy Weekly Body Weight Alloy Implant Levy, G. aut Ovadia, S. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 23(2011), 3 vom: 22. Dez., Seite 805-812 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:23 year:2011 number:3 day:22 month:12 pages:805-812 https://doi.org/10.1007/s10856-011-4536-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 23 2011 3 22 12 805-812 |
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10.1007/s10856-011-4536-8 doi (DE-627)OLC2066818909 (DE-He213)s10856-011-4536-8-p DE-627 ger DE-627 rakwb eng 610 670 VZ Aghion, E. verfasserin aut In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy 2011 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2011 Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. Corrosion Rate Magnesium Alloy Control Alloy Weekly Body Weight Alloy Implant Levy, G. aut Ovadia, S. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 23(2011), 3 vom: 22. Dez., Seite 805-812 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:23 year:2011 number:3 day:22 month:12 pages:805-812 https://doi.org/10.1007/s10856-011-4536-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 23 2011 3 22 12 805-812 |
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10.1007/s10856-011-4536-8 doi (DE-627)OLC2066818909 (DE-He213)s10856-011-4536-8-p DE-627 ger DE-627 rakwb eng 610 670 VZ Aghion, E. verfasserin aut In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy 2011 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media, LLC 2011 Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. Corrosion Rate Magnesium Alloy Control Alloy Weekly Body Weight Alloy Implant Levy, G. aut Ovadia, S. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 23(2011), 3 vom: 22. Dez., Seite 805-812 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:23 year:2011 number:3 day:22 month:12 pages:805-812 https://doi.org/10.1007/s10856-011-4536-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_23 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 23 2011 3 22 12 805-812 |
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In vivo behavior of biodegradable Mg–Nd–Y–Zr–Ca alloy |
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Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. © Springer Science+Business Media, LLC 2011 |
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Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. © Springer Science+Business Media, LLC 2011 |
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Abstract The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants. © Springer Science+Business Media, LLC 2011 |
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