3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process
Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cardea, S. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media New York 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials science / Materials in medicine - Springer US, 1990, 25(2013), 2 vom: 16. Okt., Seite 355-362 |
|---|---|
| Übergeordnetes Werk: |
volume:25 ; year:2013 ; number:2 ; day:16 ; month:10 ; pages:355-362 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10856-013-5069-0 |
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OLC2066824399 |
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| 520 | |a Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. | ||
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10.1007/s10856-013-5069-0 doi (DE-627)OLC2066824399 (DE-He213)s10856-013-5069-0-p DE-627 ger DE-627 rakwb eng 610 670 VZ Cardea, S. verfasserin aut 3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process 2013 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media New York 2013 Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. PLLA Polymer Concentration Compressive Modulus Tissue Engineering Application PLLA Scaffold Baldino, L. aut Pisanti, P. aut Reverchon, E. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 25(2013), 2 vom: 16. Okt., Seite 355-362 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:25 year:2013 number:2 day:16 month:10 pages:355-362 https://doi.org/10.1007/s10856-013-5069-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 25 2013 2 16 10 355-362 |
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10.1007/s10856-013-5069-0 doi (DE-627)OLC2066824399 (DE-He213)s10856-013-5069-0-p DE-627 ger DE-627 rakwb eng 610 670 VZ Cardea, S. verfasserin aut 3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process 2013 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media New York 2013 Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. PLLA Polymer Concentration Compressive Modulus Tissue Engineering Application PLLA Scaffold Baldino, L. aut Pisanti, P. aut Reverchon, E. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 25(2013), 2 vom: 16. Okt., Seite 355-362 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:25 year:2013 number:2 day:16 month:10 pages:355-362 https://doi.org/10.1007/s10856-013-5069-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 25 2013 2 16 10 355-362 |
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10.1007/s10856-013-5069-0 doi (DE-627)OLC2066824399 (DE-He213)s10856-013-5069-0-p DE-627 ger DE-627 rakwb eng 610 670 VZ Cardea, S. verfasserin aut 3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process 2013 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media New York 2013 Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. PLLA Polymer Concentration Compressive Modulus Tissue Engineering Application PLLA Scaffold Baldino, L. aut Pisanti, P. aut Reverchon, E. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 25(2013), 2 vom: 16. Okt., Seite 355-362 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:25 year:2013 number:2 day:16 month:10 pages:355-362 https://doi.org/10.1007/s10856-013-5069-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 25 2013 2 16 10 355-362 |
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10.1007/s10856-013-5069-0 doi (DE-627)OLC2066824399 (DE-He213)s10856-013-5069-0-p DE-627 ger DE-627 rakwb eng 610 670 VZ Cardea, S. verfasserin aut 3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process 2013 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media New York 2013 Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. PLLA Polymer Concentration Compressive Modulus Tissue Engineering Application PLLA Scaffold Baldino, L. aut Pisanti, P. aut Reverchon, E. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 25(2013), 2 vom: 16. Okt., Seite 355-362 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:25 year:2013 number:2 day:16 month:10 pages:355-362 https://doi.org/10.1007/s10856-013-5069-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 25 2013 2 16 10 355-362 |
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10.1007/s10856-013-5069-0 doi (DE-627)OLC2066824399 (DE-He213)s10856-013-5069-0-p DE-627 ger DE-627 rakwb eng 610 670 VZ Cardea, S. verfasserin aut 3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process 2013 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science+Business Media New York 2013 Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. PLLA Polymer Concentration Compressive Modulus Tissue Engineering Application PLLA Scaffold Baldino, L. aut Pisanti, P. aut Reverchon, E. aut Enthalten in Journal of materials science / Materials in medicine Springer US, 1990 25(2013), 2 vom: 16. Okt., Seite 355-362 (DE-627)130865028 (DE-600)1031752-1 (DE-576)023107537 0957-4530 nnns volume:25 year:2013 number:2 day:16 month:10 pages:355-362 https://doi.org/10.1007/s10856-013-5069-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_32 GBV_ILN_70 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4323 AR 25 2013 2 16 10 355-362 |
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3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process |
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Cardea, S. |
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Journal of materials science / Materials in medicine |
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Journal of materials science / Materials in medicine |
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eng |
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600 - Technology |
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2013 |
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355 |
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Cardea, S. Baldino, L. Pisanti, P. Reverchon, E. |
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25 |
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610 670 VZ |
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Aufsätze |
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Cardea, S. |
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10.1007/s10856-013-5069-0 |
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610 670 |
| title_sort |
3-d plla scaffolds formation by a supercritical freeze extraction assisted process |
| title_auth |
3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process |
| abstract |
Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. © Springer Science+Business Media New York 2013 |
| abstractGer |
Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. © Springer Science+Business Media New York 2013 |
| abstract_unstemmed |
Abstract Various techniques have been reported in the literature for the fabrication of biodegradable scaffolds; but, it is very difficult to obtain in the same structure macro, micro and nanostructural characteristics. In this work we developed a supercritical freeze extraction process (SFEP) for the formation of poly(l-lactic acid) (PLLA) scaffolds, that combines the advantages of thermally induced phase separation with those of supercritical drying. We processed solutions in chloroform of two PLLA molecular weights and at different polymer concentrations ranging between 5 and 20 % w/w. Supercritical drying was performed at 35 °Cand pressures ranging between 100 and 250 bar. 3-D scaffolds characterized by high porosity (between 88 and 97.5 %), with coexisting micro and nanometric morphology were obtained. Structures generated were characterized by pores ranging between 10 and 30 μm and with a wrinkled nanostructure of about 200 nm, superimposed on the internal pore surface, that could be useful for biomedical applications. A solvent residue lower than 5 ppm was also measured. © Springer Science+Business Media New York 2013 |
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| title_short |
3-D PLLA scaffolds formation by a supercritical freeze extraction assisted process |
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https://doi.org/10.1007/s10856-013-5069-0 |
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Baldino, L. Pisanti, P. Reverchon, E. |
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2024-07-04T05:24:36.738Z |
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