Properties of hybridization isotherms upon binding of ligands on microchips
Abstract A simple thermodynamic model describing microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energy...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Golovkin, M. V. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Anmerkung: |
© Pleiades Publishing, Ltd. 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Biophysics - SP MAIK Nauka/Interperiodica, 1957, 54(2009), 5 vom: Okt., Seite 581-583 |
|---|---|
| Übergeordnetes Werk: |
volume:54 ; year:2009 ; number:5 ; month:10 ; pages:581-583 |
| Links: |
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| DOI / URN: |
10.1134/S0006350909050042 |
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OLC2067719904 |
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| 520 | |a Abstract A simple thermodynamic model describing microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energy hybridization isotherm, in response to target concentration change was modeled at different ratios of oligo/target concentrations. The results of modeling were compared with the relevant and currently available data from microarray adsorption experiments. | ||
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Abstract A simple thermodynamic model describing microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energy hybridization isotherm, in response to target concentration change was modeled at different ratios of oligo/target concentrations. The results of modeling were compared with the relevant and currently available data from microarray adsorption experiments. © Pleiades Publishing, Ltd. 2009 |
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Abstract A simple thermodynamic model describing microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energy hybridization isotherm, in response to target concentration change was modeled at different ratios of oligo/target concentrations. The results of modeling were compared with the relevant and currently available data from microarray adsorption experiments. © Pleiades Publishing, Ltd. 2009 |
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Abstract A simple thermodynamic model describing microarray oligo-target hybridization has been constructed. The relationship between the hybridization signal intensity and Gibbs free energy for oligo-target duplex formation has been considered. The behavior of this function, which we called energy hybridization isotherm, in response to target concentration change was modeled at different ratios of oligo/target concentrations. The results of modeling were compared with the relevant and currently available data from microarray adsorption experiments. © Pleiades Publishing, Ltd. 2009 |
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