Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products

Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease ext...
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Autor*in:	Rosenblat, Gennady [verfasserIn] Tabak, Mina Lie Ken Jie, Marcel S. F. Neeman, Ishak

Format:	Artikel
Sprache:	Englisch

Erschienen:	1993

Anmerkung:	© the American Oil Chemists’ Society 1993

Übergeordnetes Werk:	Enthalten in: Journal of the American Oil Chemists’ Society - Springer-Verlag, 1947, 70(1993), 5 vom: Mai, Seite 501-505
Übergeordnetes Werk:	volume:70 ; year:1993 ; number:5 ; month:05 ; pages:501-505

Links:	Volltext

DOI / URN:	10.1007/BF02542584

Katalog-ID:	OLC206811898X

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520			\|a Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules.
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allfields	10.1007/BF02542584 doi (DE-627)OLC206811898X (DE-He213)BF02542584-p DE-627 ger DE-627 rakwb eng 660 VZ Rosenblat, Gennady verfasserin aut Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products 1993 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © the American Oil Chemists’ Society 1993 Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. Tabak, Mina aut Lie Ken Jie, Marcel S. F. aut Neeman, Ishak aut Enthalten in Journal of the American Oil Chemists’ Society Springer-Verlag, 1947 70(1993), 5 vom: Mai, Seite 501-505 (DE-627)129595691 (DE-600)240684-6 (DE-576)015088715 0003-021X nnns volume:70 year:1993 number:5 month:05 pages:501-505 https://doi.org/10.1007/BF02542584 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_20 GBV_ILN_23 GBV_ILN_26 GBV_ILN_70 GBV_ILN_95 GBV_ILN_183 GBV_ILN_252 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4315 AR 70 1993 5 05 501-505
spelling	10.1007/BF02542584 doi (DE-627)OLC206811898X (DE-He213)BF02542584-p DE-627 ger DE-627 rakwb eng 660 VZ Rosenblat, Gennady verfasserin aut Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products 1993 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © the American Oil Chemists’ Society 1993 Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. Tabak, Mina aut Lie Ken Jie, Marcel S. F. aut Neeman, Ishak aut Enthalten in Journal of the American Oil Chemists’ Society Springer-Verlag, 1947 70(1993), 5 vom: Mai, Seite 501-505 (DE-627)129595691 (DE-600)240684-6 (DE-576)015088715 0003-021X nnns volume:70 year:1993 number:5 month:05 pages:501-505 https://doi.org/10.1007/BF02542584 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_20 GBV_ILN_23 GBV_ILN_26 GBV_ILN_70 GBV_ILN_95 GBV_ILN_183 GBV_ILN_252 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4315 AR 70 1993 5 05 501-505
allfields_unstemmed	10.1007/BF02542584 doi (DE-627)OLC206811898X (DE-He213)BF02542584-p DE-627 ger DE-627 rakwb eng 660 VZ Rosenblat, Gennady verfasserin aut Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products 1993 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © the American Oil Chemists’ Society 1993 Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. Tabak, Mina aut Lie Ken Jie, Marcel S. F. aut Neeman, Ishak aut Enthalten in Journal of the American Oil Chemists’ Society Springer-Verlag, 1947 70(1993), 5 vom: Mai, Seite 501-505 (DE-627)129595691 (DE-600)240684-6 (DE-576)015088715 0003-021X nnns volume:70 year:1993 number:5 month:05 pages:501-505 https://doi.org/10.1007/BF02542584 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_20 GBV_ILN_23 GBV_ILN_26 GBV_ILN_70 GBV_ILN_95 GBV_ILN_183 GBV_ILN_252 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4315 AR 70 1993 5 05 501-505
allfieldsGer	10.1007/BF02542584 doi (DE-627)OLC206811898X (DE-He213)BF02542584-p DE-627 ger DE-627 rakwb eng 660 VZ Rosenblat, Gennady verfasserin aut Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products 1993 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © the American Oil Chemists’ Society 1993 Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. Tabak, Mina aut Lie Ken Jie, Marcel S. F. aut Neeman, Ishak aut Enthalten in Journal of the American Oil Chemists’ Society Springer-Verlag, 1947 70(1993), 5 vom: Mai, Seite 501-505 (DE-627)129595691 (DE-600)240684-6 (DE-576)015088715 0003-021X nnns volume:70 year:1993 number:5 month:05 pages:501-505 https://doi.org/10.1007/BF02542584 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_20 GBV_ILN_23 GBV_ILN_26 GBV_ILN_70 GBV_ILN_95 GBV_ILN_183 GBV_ILN_252 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4315 AR 70 1993 5 05 501-505
allfieldsSound	10.1007/BF02542584 doi (DE-627)OLC206811898X (DE-He213)BF02542584-p DE-627 ger DE-627 rakwb eng 660 VZ Rosenblat, Gennady verfasserin aut Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products 1993 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © the American Oil Chemists’ Society 1993 Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. Tabak, Mina aut Lie Ken Jie, Marcel S. F. aut Neeman, Ishak aut Enthalten in Journal of the American Oil Chemists’ Society Springer-Verlag, 1947 70(1993), 5 vom: Mai, Seite 501-505 (DE-627)129595691 (DE-600)240684-6 (DE-576)015088715 0003-021X nnns volume:70 year:1993 number:5 month:05 pages:501-505 https://doi.org/10.1007/BF02542584 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_20 GBV_ILN_23 GBV_ILN_26 GBV_ILN_70 GBV_ILN_95 GBV_ILN_183 GBV_ILN_252 GBV_ILN_4012 GBV_ILN_4046 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4315 AR 70 1993 5 05 501-505
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title_sort	inhibition of bacterial urease by autoxidation of furan c-18 fatty acid methyl ester products
title_auth	Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products
abstract	Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. © the American Oil Chemists’ Society 1993
abstractGer	Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. © the American Oil Chemists’ Society 1993
abstract_unstemmed	Abstract Autoxidation products of synthetic methyl 9,12-epoxy-octadeca-9,11-dienoate (MEFA) were investigated by gas chromatography-mass spectrometry analysis and tested for bacterial urease inhibition. A suspension of oxidized MEFA in 10% Tween 80 was an effective inhibitor for bacterial urease extract fromHelicobacter pylori ($ I_{50} $=1.3 mM) and for commercial urease fromBacillus pasteurii ($ I_{50} $=0.06 mM). The urease inhibitory effect was cancelled by adding cysteine to the reaction mixture. The total content of biologically active oxidized products in the mixture was found to be 6.2%. Dioxo-ene derivatives of MEFA on the thin-layer chromatography plate surface were converted into more stable compounds, whose formation in the mixture reduced inhibition ofB. pasteurii to about 2% of the former level. The mechanism of urease inhibition is supposed to involve the interaction of the thiol groups of the enzyme’s active center with the inhibitor molecules. © the American Oil Chemists’ Society 1993
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container_issue	5
title_short	Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products
url	https://doi.org/10.1007/BF02542584
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author2	Tabak, Mina Lie Ken Jie, Marcel S. F. Neeman, Ishak
author2Str	Tabak, Mina Lie Ken Jie, Marcel S. F. Neeman, Ishak
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doi_str	10.1007/BF02542584
up_date	2024-07-03T17:39:07.202Z
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Inhibition of bacterial urease by autoxidation of furan C-18 fatty acid methyl ester products

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