Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes
Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different patholog...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kalniņa, Inta [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2005 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© Springer Science + Business Media, Inc. 2005 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Journal of fluorescence - Kluwer Academic Publishers-Plenum Publishers, 1991, 15(2005), 2 vom: März, Seite 105-110 |
|---|---|
| Übergeordnetes Werk: |
volume:15 ; year:2005 ; number:2 ; month:03 ; pages:105-110 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10895-005-2516-4 |
|---|
| Katalog-ID: |
OLC2070041735 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2070041735 | ||
| 003 | DE-627 | ||
| 005 | 20230510185010.0 | ||
| 007 | tu | ||
| 008 | 200819s2005 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10895-005-2516-4 |2 doi | |
| 035 | |a (DE-627)OLC2070041735 | ||
| 035 | |a (DE-He213)s10895-005-2516-4-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 620 |q VZ |
| 100 | 1 | |a Kalniņa, Inta |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| 264 | 1 | |c 2005 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer Science + Business Media, Inc. 2005 | ||
| 520 | |a Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. | ||
| 650 | 4 | |a Fluorescent probe | |
| 650 | 4 | |a lymphocytes | |
| 650 | 4 | |a rheumatoid arthrilis | |
| 650 | 4 | |a diagnostics | |
| 700 | 1 | |a Zvagule, Tija |4 aut | |
| 700 | 1 | |a Brū, Rū |4 aut | |
| 700 | 1 | |a Meirovics, Imants |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of fluorescence |d Kluwer Academic Publishers-Plenum Publishers, 1991 |g 15(2005), 2 vom: März, Seite 105-110 |w (DE-627)130988731 |w (DE-600)1079500-5 |w (DE-576)030293898 |x 1053-0509 |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:2005 |g number:2 |g month:03 |g pages:105-110 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s10895-005-2516-4 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-TEC | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_4125 | ||
| 951 | |a AR | ||
| 952 | |d 15 |j 2005 |e 2 |c 03 |h 105-110 | ||
| author_variant |
i k ik t z tz r b rb i m im |
|---|---|
| matchkey_str |
article:10530509:2005----::loecncaatrsisfhuaodrhiipt |
| hierarchy_sort_str |
2005 |
| publishDate |
2005 |
| allfields |
10.1007/s10895-005-2516-4 doi (DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p DE-627 ger DE-627 rakwb eng 620 VZ Kalniņa, Inta verfasserin aut Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2005 Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics Zvagule, Tija aut Brū, Rū aut Meirovics, Imants aut Enthalten in Journal of fluorescence Kluwer Academic Publishers-Plenum Publishers, 1991 15(2005), 2 vom: März, Seite 105-110 (DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 1053-0509 nnns volume:15 year:2005 number:2 month:03 pages:105-110 https://doi.org/10.1007/s10895-005-2516-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 AR 15 2005 2 03 105-110 |
| spelling |
10.1007/s10895-005-2516-4 doi (DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p DE-627 ger DE-627 rakwb eng 620 VZ Kalniņa, Inta verfasserin aut Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2005 Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics Zvagule, Tija aut Brū, Rū aut Meirovics, Imants aut Enthalten in Journal of fluorescence Kluwer Academic Publishers-Plenum Publishers, 1991 15(2005), 2 vom: März, Seite 105-110 (DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 1053-0509 nnns volume:15 year:2005 number:2 month:03 pages:105-110 https://doi.org/10.1007/s10895-005-2516-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 AR 15 2005 2 03 105-110 |
| allfields_unstemmed |
10.1007/s10895-005-2516-4 doi (DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p DE-627 ger DE-627 rakwb eng 620 VZ Kalniņa, Inta verfasserin aut Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2005 Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics Zvagule, Tija aut Brū, Rū aut Meirovics, Imants aut Enthalten in Journal of fluorescence Kluwer Academic Publishers-Plenum Publishers, 1991 15(2005), 2 vom: März, Seite 105-110 (DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 1053-0509 nnns volume:15 year:2005 number:2 month:03 pages:105-110 https://doi.org/10.1007/s10895-005-2516-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 AR 15 2005 2 03 105-110 |
| allfieldsGer |
10.1007/s10895-005-2516-4 doi (DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p DE-627 ger DE-627 rakwb eng 620 VZ Kalniņa, Inta verfasserin aut Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2005 Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics Zvagule, Tija aut Brū, Rū aut Meirovics, Imants aut Enthalten in Journal of fluorescence Kluwer Academic Publishers-Plenum Publishers, 1991 15(2005), 2 vom: März, Seite 105-110 (DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 1053-0509 nnns volume:15 year:2005 number:2 month:03 pages:105-110 https://doi.org/10.1007/s10895-005-2516-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 AR 15 2005 2 03 105-110 |
| allfieldsSound |
10.1007/s10895-005-2516-4 doi (DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p DE-627 ger DE-627 rakwb eng 620 VZ Kalniņa, Inta verfasserin aut Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer Science + Business Media, Inc. 2005 Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics Zvagule, Tija aut Brū, Rū aut Meirovics, Imants aut Enthalten in Journal of fluorescence Kluwer Academic Publishers-Plenum Publishers, 1991 15(2005), 2 vom: März, Seite 105-110 (DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 1053-0509 nnns volume:15 year:2005 number:2 month:03 pages:105-110 https://doi.org/10.1007/s10895-005-2516-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 AR 15 2005 2 03 105-110 |
| language |
English |
| source |
Enthalten in Journal of fluorescence 15(2005), 2 vom: März, Seite 105-110 volume:15 year:2005 number:2 month:03 pages:105-110 |
| sourceStr |
Enthalten in Journal of fluorescence 15(2005), 2 vom: März, Seite 105-110 volume:15 year:2005 number:2 month:03 pages:105-110 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics |
| dewey-raw |
620 |
| isfreeaccess_bool |
false |
| container_title |
Journal of fluorescence |
| authorswithroles_txt_mv |
Kalniņa, Inta @@aut@@ Zvagule, Tija @@aut@@ Brū, Rū @@aut@@ Meirovics, Imants @@aut@@ |
| publishDateDaySort_date |
2005-03-01T00:00:00Z |
| hierarchy_top_id |
130988731 |
| dewey-sort |
3620 |
| id |
OLC2070041735 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2070041735</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230510185010.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200819s2005 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10895-005-2516-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2070041735</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)s10895-005-2516-4-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">620</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kalniņa, Inta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2005</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer Science + Business Media, Inc. 2005</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluorescent probe</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lymphocytes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rheumatoid arthrilis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">diagnostics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zvagule, Tija</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brū, Rū</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Meirovics, Imants</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of fluorescence</subfield><subfield code="d">Kluwer Academic Publishers-Plenum Publishers, 1991</subfield><subfield code="g">15(2005), 2 vom: März, Seite 105-110</subfield><subfield code="w">(DE-627)130988731</subfield><subfield code="w">(DE-600)1079500-5</subfield><subfield code="w">(DE-576)030293898</subfield><subfield code="x">1053-0509</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:15</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:2</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:105-110</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/s10895-005-2516-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">15</subfield><subfield code="j">2005</subfield><subfield code="e">2</subfield><subfield code="c">03</subfield><subfield code="h">105-110</subfield></datafield></record></collection>
|
| author |
Kalniņa, Inta |
| spellingShingle |
Kalniņa, Inta ddc 620 misc Fluorescent probe misc lymphocytes misc rheumatoid arthrilis misc diagnostics Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| authorStr |
Kalniņa, Inta |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)130988731 |
| format |
Article |
| dewey-ones |
620 - Engineering & allied operations |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
1053-0509 |
| topic_title |
620 VZ Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes Fluorescent probe lymphocytes rheumatoid arthrilis diagnostics |
| topic |
ddc 620 misc Fluorescent probe misc lymphocytes misc rheumatoid arthrilis misc diagnostics |
| topic_unstemmed |
ddc 620 misc Fluorescent probe misc lymphocytes misc rheumatoid arthrilis misc diagnostics |
| topic_browse |
ddc 620 misc Fluorescent probe misc lymphocytes misc rheumatoid arthrilis misc diagnostics |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| hierarchy_parent_title |
Journal of fluorescence |
| hierarchy_parent_id |
130988731 |
| dewey-tens |
620 - Engineering |
| hierarchy_top_title |
Journal of fluorescence |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)130988731 (DE-600)1079500-5 (DE-576)030293898 |
| title |
Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| ctrlnum |
(DE-627)OLC2070041735 (DE-He213)s10895-005-2516-4-p |
| title_full |
Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| author_sort |
Kalniņa, Inta |
| journal |
Journal of fluorescence |
| journalStr |
Journal of fluorescence |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2005 |
| contenttype_str_mv |
txt |
| container_start_page |
105 |
| author_browse |
Kalniņa, Inta Zvagule, Tija Brū, Rū Meirovics, Imants |
| container_volume |
15 |
| class |
620 VZ |
| format_se |
Aufsätze |
| author-letter |
Kalniņa, Inta |
| doi_str_mv |
10.1007/s10895-005-2516-4 |
| dewey-full |
620 |
| title_sort |
fluorescent characteristics of rheumatoid arthritis patients blood lymphocytes |
| title_auth |
Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| abstract |
Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. © Springer Science + Business Media, Inc. 2005 |
| abstractGer |
Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. © Springer Science + Business Media, Inc. 2005 |
| abstract_unstemmed |
Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients. © Springer Science + Business Media, Inc. 2005 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_285 GBV_ILN_2004 GBV_ILN_4125 |
| container_issue |
2 |
| title_short |
Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes |
| url |
https://doi.org/10.1007/s10895-005-2516-4 |
| remote_bool |
false |
| author2 |
Zvagule, Tija Brū, Rū Meirovics, Imants |
| author2Str |
Zvagule, Tija Brū, Rū Meirovics, Imants |
| ppnlink |
130988731 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s10895-005-2516-4 |
| up_date |
2024-07-04T00:04:03.401Z |
| _version_ |
1803604662317744128 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2070041735</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230510185010.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200819s2005 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s10895-005-2516-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2070041735</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)s10895-005-2516-4-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">620</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kalniņa, Inta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Fluorescent Characteristics of Rheumatoid Arthritis Patients Blood Lymphocytes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2005</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer Science + Business Media, Inc. 2005</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract A fluorescent probe, ABM, aminoderivative of benzanthrone, synthesized in the Department of Organic Chemistry of the Riga Technical University (Latvia), has been successfully used to characterize changes in the structural and functional properties of cell membranes during different pathologies. In the present study the physicochemical properties and the functional activity of the peripheral blood mononuclear cells (lymphocytes—Ly) in patients with rheumatoid arthritis (RA) were studied using the ABM probe. Intensity of the ABM fluorescence in the celi suspension, functional activity of the ly anisotropy of the membranes differ patients with different titres of rheumatoid factor in blood. Patients with seropositive RA had decreased proliferative activity and lower number of iy in blood plasma indicating greater alterations of the immunoregulating processes in these patients as compared to patients with seronegative RA. In the latter the Ly deficiency is compensated to some extent by increased proliferation activity of these cells. The ABM fluorescence intensity correlated not only with membrane anisotropy (r = 0.97, but also with the proliferation activity of the Ly (r = 0.98). The above parameters correlated with the clinical manifestations of the disease. The results indicate that the fluorescent probe ABM is useful for screening the physicochemical status of Ly membranes and the proliferation activity of these cells in RA patients.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluorescent probe</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lymphocytes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rheumatoid arthrilis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">diagnostics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zvagule, Tija</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brū, Rū</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Meirovics, Imants</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of fluorescence</subfield><subfield code="d">Kluwer Academic Publishers-Plenum Publishers, 1991</subfield><subfield code="g">15(2005), 2 vom: März, Seite 105-110</subfield><subfield code="w">(DE-627)130988731</subfield><subfield code="w">(DE-600)1079500-5</subfield><subfield code="w">(DE-576)030293898</subfield><subfield code="x">1053-0509</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:15</subfield><subfield code="g">year:2005</subfield><subfield code="g">number:2</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:105-110</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/s10895-005-2516-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">15</subfield><subfield code="j">2005</subfield><subfield code="e">2</subfield><subfield code="c">03</subfield><subfield code="h">105-110</subfield></datafield></record></collection>
|
| score |
7.400943 |