Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers
Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead l...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Duydu, Y. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2001 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag New York Inc. 2001 |
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| Übergeordnetes Werk: |
Enthalten in: Archives of environmental contamination and toxicology - Springer-Verlag, 1973, 41(2001), 2 vom: Aug., Seite 241-246 |
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| Übergeordnetes Werk: |
volume:41 ; year:2001 ; number:2 ; month:08 ; pages:241-246 |
| Links: |
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| DOI / URN: |
10.1007/s002440010244 |
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| Katalog-ID: |
OLC2070701344 |
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| 520 | |a Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. | ||
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10.1007/s002440010244 doi (DE-627)OLC2070701344 (DE-He213)s002440010244-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Duydu, Y. verfasserin aut Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers 2001 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2001 Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. Average Level Lead Concentration Lead Level Lead Exposure Genotoxic Effect Süzen, H. S. aut Aydin, A. aut Cander, O. aut Uysal, H. aut Işimer, A. aut Vural, N. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 41(2001), 2 vom: Aug., Seite 241-246 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:41 year:2001 number:2 month:08 pages:241-246 https://doi.org/10.1007/s002440010244 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_601 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 41 2001 2 08 241-246 |
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10.1007/s002440010244 doi (DE-627)OLC2070701344 (DE-He213)s002440010244-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Duydu, Y. verfasserin aut Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers 2001 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2001 Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. Average Level Lead Concentration Lead Level Lead Exposure Genotoxic Effect Süzen, H. S. aut Aydin, A. aut Cander, O. aut Uysal, H. aut Işimer, A. aut Vural, N. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 41(2001), 2 vom: Aug., Seite 241-246 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:41 year:2001 number:2 month:08 pages:241-246 https://doi.org/10.1007/s002440010244 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_601 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 41 2001 2 08 241-246 |
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10.1007/s002440010244 doi (DE-627)OLC2070701344 (DE-He213)s002440010244-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Duydu, Y. verfasserin aut Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers 2001 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2001 Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. Average Level Lead Concentration Lead Level Lead Exposure Genotoxic Effect Süzen, H. S. aut Aydin, A. aut Cander, O. aut Uysal, H. aut Işimer, A. aut Vural, N. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 41(2001), 2 vom: Aug., Seite 241-246 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:41 year:2001 number:2 month:08 pages:241-246 https://doi.org/10.1007/s002440010244 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_601 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 41 2001 2 08 241-246 |
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10.1007/s002440010244 doi (DE-627)OLC2070701344 (DE-He213)s002440010244-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Duydu, Y. verfasserin aut Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers 2001 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2001 Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. Average Level Lead Concentration Lead Level Lead Exposure Genotoxic Effect Süzen, H. S. aut Aydin, A. aut Cander, O. aut Uysal, H. aut Işimer, A. aut Vural, N. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 41(2001), 2 vom: Aug., Seite 241-246 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:41 year:2001 number:2 month:08 pages:241-246 https://doi.org/10.1007/s002440010244 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_601 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 41 2001 2 08 241-246 |
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10.1007/s002440010244 doi (DE-627)OLC2070701344 (DE-He213)s002440010244-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Duydu, Y. verfasserin aut Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers 2001 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2001 Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. Average Level Lead Concentration Lead Level Lead Exposure Genotoxic Effect Süzen, H. S. aut Aydin, A. aut Cander, O. aut Uysal, H. aut Işimer, A. aut Vural, N. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 41(2001), 2 vom: Aug., Seite 241-246 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:41 year:2001 number:2 month:08 pages:241-246 https://doi.org/10.1007/s002440010244 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_601 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 41 2001 2 08 241-246 |
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Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers |
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correlation between lead exposure indicators and sister chromatid exchange (sce) frequencies in lymphocytes from inorganic lead exposed workers |
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Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers |
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Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. © Springer-Verlag New York Inc. 2001 |
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Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. © Springer-Verlag New York Inc. 2001 |
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Abstract Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. © Springer-Verlag New York Inc. 2001 |
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