Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing
Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metaboli...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chang, M. J. W. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2002 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag New York Inc. 2002 |
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| Übergeordnetes Werk: |
Enthalten in: Archives of environmental contamination and toxicology - Springer-Verlag, 1973, 43(2002), 4 vom: Nov., Seite 0432-0437 |
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| Übergeordnetes Werk: |
volume:43 ; year:2002 ; number:4 ; month:11 ; pages:0432-0437 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00244-002-1241-0 |
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| Katalog-ID: |
OLC2070703118 |
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| 520 | |a Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). | ||
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| 700 | 1 | |a Lin, R. F. |4 aut | |
| 700 | 1 | |a Hsieh, L. L. |4 aut | |
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10.1007/s00244-002-1241-0 doi (DE-627)OLC2070703118 (DE-He213)s00244-002-1241-0-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Chang, M. J. W. verfasserin aut Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2002 Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). Lime Urine Sample Environment Exposure Good Linearity Human Urine Ko, C. Y. aut Lin, R. F. aut Hsieh, L. L. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 43(2002), 4 vom: Nov., Seite 0432-0437 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:43 year:2002 number:4 month:11 pages:0432-0437 https://doi.org/10.1007/s00244-002-1241-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 43 2002 4 11 0432-0437 |
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10.1007/s00244-002-1241-0 doi (DE-627)OLC2070703118 (DE-He213)s00244-002-1241-0-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Chang, M. J. W. verfasserin aut Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2002 Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). Lime Urine Sample Environment Exposure Good Linearity Human Urine Ko, C. Y. aut Lin, R. F. aut Hsieh, L. L. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 43(2002), 4 vom: Nov., Seite 0432-0437 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:43 year:2002 number:4 month:11 pages:0432-0437 https://doi.org/10.1007/s00244-002-1241-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 43 2002 4 11 0432-0437 |
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10.1007/s00244-002-1241-0 doi (DE-627)OLC2070703118 (DE-He213)s00244-002-1241-0-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Chang, M. J. W. verfasserin aut Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2002 Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). Lime Urine Sample Environment Exposure Good Linearity Human Urine Ko, C. Y. aut Lin, R. F. aut Hsieh, L. L. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 43(2002), 4 vom: Nov., Seite 0432-0437 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:43 year:2002 number:4 month:11 pages:0432-0437 https://doi.org/10.1007/s00244-002-1241-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 43 2002 4 11 0432-0437 |
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10.1007/s00244-002-1241-0 doi (DE-627)OLC2070703118 (DE-He213)s00244-002-1241-0-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Chang, M. J. W. verfasserin aut Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2002 Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). Lime Urine Sample Environment Exposure Good Linearity Human Urine Ko, C. Y. aut Lin, R. F. aut Hsieh, L. L. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 43(2002), 4 vom: Nov., Seite 0432-0437 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:43 year:2002 number:4 month:11 pages:0432-0437 https://doi.org/10.1007/s00244-002-1241-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 43 2002 4 11 0432-0437 |
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10.1007/s00244-002-1241-0 doi (DE-627)OLC2070703118 (DE-He213)s00244-002-1241-0-p DE-627 ger DE-627 rakwb eng 333.7 610 VZ Chang, M. J. W. verfasserin aut Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing 2002 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag New York Inc. 2002 Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). Lime Urine Sample Environment Exposure Good Linearity Human Urine Ko, C. Y. aut Lin, R. F. aut Hsieh, L. L. aut Enthalten in Archives of environmental contamination and toxicology Springer-Verlag, 1973 43(2002), 4 vom: Nov., Seite 0432-0437 (DE-627)129397725 (DE-600)185986-9 (DE-576)01478100X 0090-4341 nnns volume:43 year:2002 number:4 month:11 pages:0432-0437 https://doi.org/10.1007/s00244-002-1241-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_11 GBV_ILN_21 GBV_ILN_23 GBV_ILN_31 GBV_ILN_69 GBV_ILN_70 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2018 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 GBV_ILN_4313 AR 43 2002 4 11 0432-0437 |
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biological monitoring of environment exposure to safrole and the taiwanese betel quid chewing |
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Biological Monitoring of Environment Exposure to Safrole and the Taiwanese Betel Quid Chewing |
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Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). © Springer-Verlag New York Inc. 2002 |
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Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). © Springer-Verlag New York Inc. 2002 |
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Abstract A rapid and sensitive biological monitoring (BM) method for assessing exposure to the environmental carcinogen safrole has been developed. The method is an isocratic high-performance liquid chromatographic (HPLC) analysis of urinary dihydroxychavicol (DHAB) and eugenol, the urinary metabolites of safrole. Good linearity, precision, and accuracy were demonstrated. A recovery of 98.8 ± 5.4% (SD, n = 3) was found for DHAB and 84.1 ± 3.4% (n = 3) for eugenol. The quantitation limits of the method were 8 ng for DHAB and 10 ng for eugenol. The validity of the method was demonstrated by a linear dose-response relationship observed in rats given oral doses of safrole at 30, 75, and 150 mg/kg body weight. The method was also used to monitor the environmental exposure to the Taiwanese betel quid (TBQ) chewing, because TBQ used in Taiwan not only contains areca (betel) nut, slaked lime, and catechu but also Piper betle inflorescence or its leaves. Both of the latter have a high content of safrole. The feasibility of the method to monitor TBQ chewing was demonstrated by an analysis of 153 spot human urine samples. The results showed that the p value of the nonparametric group comparison was < 0.001 for DHAB and 0.832 for eugenol. The TBQ chewers also exhibited a significantly higher rate of urinary DHAB (but not eugenol) than the nonchewers with an odd ratio of 3.47 (95% CI, 1.61–7.51). However, when only the eugenol-positive subjects were taken into analysis, the ratio rose to 24.38 (95% CI, 3.00–197.90). © Springer-Verlag New York Inc. 2002 |
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