Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation

Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lücke-Huhle, C. [verfasserIn] Comper, W. Hieber, L. Pech, M.

Format:	Artikel
Sprache:	Englisch

Erschienen:	1982

Schlagwörter:	Endpoint Anemia Cell Killing Environmental Physic Normal Individual

Anmerkung:	© Springer-Verlag 1982

Übergeordnetes Werk:	Enthalten in: Radiation and environmental biophysics - Springer-Verlag, 1974, 20(1982), 3 vom: Sept., Seite 171-185
Übergeordnetes Werk:	volume:20 ; year:1982 ; number:3 ; month:09 ; pages:171-185

Links:	Volltext

DOI / URN:	10.1007/BF01325466

Katalog-ID:	OLC2075406995

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allfields	10.1007/BF01325466 doi (DE-627)OLC2075406995 (DE-He213)BF01325466-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Lücke-Huhle, C. verfasserin aut Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 1982 Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Endpoint Anemia Cell Killing Environmental Physic Normal Individual Comper, W. aut Hieber, L. aut Pech, M. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 20(1982), 3 vom: Sept., Seite 171-185 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:20 year:1982 number:3 month:09 pages:171-185 https://doi.org/10.1007/BF01325466 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_101 GBV_ILN_105 GBV_ILN_170 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4310 GBV_ILN_4323 AR 20 1982 3 09 171-185
spelling	10.1007/BF01325466 doi (DE-627)OLC2075406995 (DE-He213)BF01325466-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Lücke-Huhle, C. verfasserin aut Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 1982 Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Endpoint Anemia Cell Killing Environmental Physic Normal Individual Comper, W. aut Hieber, L. aut Pech, M. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 20(1982), 3 vom: Sept., Seite 171-185 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:20 year:1982 number:3 month:09 pages:171-185 https://doi.org/10.1007/BF01325466 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_101 GBV_ILN_105 GBV_ILN_170 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4310 GBV_ILN_4323 AR 20 1982 3 09 171-185
allfields_unstemmed	10.1007/BF01325466 doi (DE-627)OLC2075406995 (DE-He213)BF01325466-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Lücke-Huhle, C. verfasserin aut Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 1982 Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Endpoint Anemia Cell Killing Environmental Physic Normal Individual Comper, W. aut Hieber, L. aut Pech, M. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 20(1982), 3 vom: Sept., Seite 171-185 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:20 year:1982 number:3 month:09 pages:171-185 https://doi.org/10.1007/BF01325466 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_101 GBV_ILN_105 GBV_ILN_170 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4310 GBV_ILN_4323 AR 20 1982 3 09 171-185
allfieldsGer	10.1007/BF01325466 doi (DE-627)OLC2075406995 (DE-He213)BF01325466-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Lücke-Huhle, C. verfasserin aut Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 1982 Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. Endpoint Anemia Cell Killing Environmental Physic Normal Individual Comper, W. aut Hieber, L. aut Pech, M. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 20(1982), 3 vom: Sept., Seite 171-185 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:20 year:1982 number:3 month:09 pages:171-185 https://doi.org/10.1007/BF01325466 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_101 GBV_ILN_105 GBV_ILN_170 GBV_ILN_252 GBV_ILN_2006 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4306 GBV_ILN_4310 GBV_ILN_4323 AR 20 1982 3 09 171-185
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source	Enthalten in Radiation and environmental biophysics 20(1982), 3 vom: Sept., Seite 171-185 volume:20 year:1982 number:3 month:09 pages:171-185
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author	Lücke-Huhle, C.
spellingShingle	Lücke-Huhle, C. ddc 570 ssgn 12 fid BIODIV misc Endpoint misc Anemia misc Cell Killing misc Environmental Physic misc Normal Individual Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation
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topic_title	570 530 VZ 12 ssgn BIODIV DE-30 fid Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation Endpoint Anemia Cell Killing Environmental Physic Normal Individual
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title	Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation
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title_full	Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation
author_sort	Lücke-Huhle, C.
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title_sort	comparative study of g2 delay and survival $ after^{241} $americium-α $ and^{60} $cobalt-γ irradiation
title_auth	Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation
abstract	Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. © Springer-Verlag 1982
abstractGer	Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. © Springer-Verlag 1982
abstract_unstemmed	Summary Survival and G2 delay following exposure to $ either^{60} $Cobalt-γ-rays $ or^{241} $Americium-α-paticles were studied in eight mammalian cell lines of human and animal origin including human fibroblasts from normal individuals and from patients with Ataxia telangiectasia or Fanconi's anemia. For both endpoints the effectiveness of alpha particles was greater as compared toγ-rays. RBE values for G2 delay (4.6–9.2) were in general comparable to RBE values derived from initial slopes of survival curves ($ RBE_{α} $) but higher compared to the ratio of mean inactivation doses$$\left( {RB_{\bar DML} } \right)$$. Ataxia cells were particularly sensitive to cell killing byγ-irradiation ($ D_{37} $ = 0.57 Gy), however, showed average sensitivity toα-particles of high LET ($ D_{37} $ = 0.30 Gy). With the exception of Ataxia cells, cell killing and G2 delay seem to be related processes if individual cell cycle parameters are taken into account. © Springer-Verlag 1982
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title_short	Comparative study of G2 delay and survival $ after^{241} $Americium-α $ and^{60} $Cobalt-γ irradiation
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