Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells
Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Göggelmann, W. [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2003 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© Springer-Verlag 2003 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Radiation and environmental biophysics - Springer-Verlag, 1974, 42(2003), 3 vom: Okt., Seite 175-182 |
|---|---|
| Übergeordnetes Werk: |
volume:42 ; year:2003 ; number:3 ; month:10 ; pages:175-182 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00411-003-0210-y |
|---|
| Katalog-ID: |
OLC2075415560 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2075415560 | ||
| 003 | DE-627 | ||
| 005 | 20230402231322.0 | ||
| 007 | tu | ||
| 008 | 200820s2003 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00411-003-0210-y |2 doi | |
| 035 | |a (DE-627)OLC2075415560 | ||
| 035 | |a (DE-He213)s00411-003-0210-y-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 570 |a 530 |q VZ |
| 084 | |a 12 |2 ssgn | ||
| 084 | |a BIODIV |q DE-30 |2 fid | ||
| 100 | 1 | |a Göggelmann, W. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| 264 | 1 | |c 2003 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer-Verlag 2003 | ||
| 520 | |a Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. | ||
| 650 | 4 | |a Neoplastic Transformation | |
| 650 | 4 | |a Transformation Frequency | |
| 650 | 4 | |a Relative Biological Effectiveness | |
| 650 | 4 | |a Target Chromosome | |
| 650 | 4 | |a High Relative Biological Effectiveness | |
| 700 | 1 | |a Jacobsen, C. |4 aut | |
| 700 | 1 | |a Panzer, W. |4 aut | |
| 700 | 1 | |a Walsh, L. |4 aut | |
| 700 | 1 | |a Roos, H. |4 aut | |
| 700 | 1 | |a Schmid, E. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiation and environmental biophysics |d Springer-Verlag, 1974 |g 42(2003), 3 vom: Okt., Seite 175-182 |w (DE-627)129308528 |w (DE-600)124987-3 |w (DE-576)014507870 |x 0301-634X |7 nnns |
| 773 | 1 | 8 | |g volume:42 |g year:2003 |g number:3 |g month:10 |g pages:175-182 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s00411-003-0210-y |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a FID-BIODIV | ||
| 912 | |a SSG-OLC-PHY | ||
| 912 | |a SSG-OPC-GGO | ||
| 912 | |a GBV_ILN_11 | ||
| 912 | |a GBV_ILN_21 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_2018 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4082 | ||
| 912 | |a GBV_ILN_4219 | ||
| 912 | |a GBV_ILN_4277 | ||
| 951 | |a AR | ||
| 952 | |d 42 |j 2003 |e 3 |c 10 |h 175-182 | ||
| author_variant |
w g wg c j cj w p wp l w lw h r hr e s es |
|---|---|
| matchkey_str |
article:0301634X:2003----::evlainfhref9vrymmorpyryrltvt20vryuigepatcrn |
| hierarchy_sort_str |
2003 |
| publishDate |
2003 |
| allfields |
10.1007/s00411-003-0210-y doi (DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Göggelmann, W. verfasserin aut Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells 2003 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2003 Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness Jacobsen, C. aut Panzer, W. aut Walsh, L. aut Roos, H. aut Schmid, E. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 42(2003), 3 vom: Okt., Seite 175-182 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:42 year:2003 number:3 month:10 pages:175-182 https://doi.org/10.1007/s00411-003-0210-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 AR 42 2003 3 10 175-182 |
| spelling |
10.1007/s00411-003-0210-y doi (DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Göggelmann, W. verfasserin aut Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells 2003 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2003 Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness Jacobsen, C. aut Panzer, W. aut Walsh, L. aut Roos, H. aut Schmid, E. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 42(2003), 3 vom: Okt., Seite 175-182 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:42 year:2003 number:3 month:10 pages:175-182 https://doi.org/10.1007/s00411-003-0210-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 AR 42 2003 3 10 175-182 |
| allfields_unstemmed |
10.1007/s00411-003-0210-y doi (DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Göggelmann, W. verfasserin aut Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells 2003 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2003 Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness Jacobsen, C. aut Panzer, W. aut Walsh, L. aut Roos, H. aut Schmid, E. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 42(2003), 3 vom: Okt., Seite 175-182 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:42 year:2003 number:3 month:10 pages:175-182 https://doi.org/10.1007/s00411-003-0210-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 AR 42 2003 3 10 175-182 |
| allfieldsGer |
10.1007/s00411-003-0210-y doi (DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Göggelmann, W. verfasserin aut Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells 2003 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2003 Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness Jacobsen, C. aut Panzer, W. aut Walsh, L. aut Roos, H. aut Schmid, E. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 42(2003), 3 vom: Okt., Seite 175-182 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:42 year:2003 number:3 month:10 pages:175-182 https://doi.org/10.1007/s00411-003-0210-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 AR 42 2003 3 10 175-182 |
| allfieldsSound |
10.1007/s00411-003-0210-y doi (DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Göggelmann, W. verfasserin aut Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells 2003 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2003 Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness Jacobsen, C. aut Panzer, W. aut Walsh, L. aut Roos, H. aut Schmid, E. aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 42(2003), 3 vom: Okt., Seite 175-182 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:42 year:2003 number:3 month:10 pages:175-182 https://doi.org/10.1007/s00411-003-0210-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 AR 42 2003 3 10 175-182 |
| language |
English |
| source |
Enthalten in Radiation and environmental biophysics 42(2003), 3 vom: Okt., Seite 175-182 volume:42 year:2003 number:3 month:10 pages:175-182 |
| sourceStr |
Enthalten in Radiation and environmental biophysics 42(2003), 3 vom: Okt., Seite 175-182 volume:42 year:2003 number:3 month:10 pages:175-182 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness |
| dewey-raw |
570 |
| isfreeaccess_bool |
false |
| container_title |
Radiation and environmental biophysics |
| authorswithroles_txt_mv |
Göggelmann, W. @@aut@@ Jacobsen, C. @@aut@@ Panzer, W. @@aut@@ Walsh, L. @@aut@@ Roos, H. @@aut@@ Schmid, E. @@aut@@ |
| publishDateDaySort_date |
2003-10-01T00:00:00Z |
| hierarchy_top_id |
129308528 |
| dewey-sort |
3570 |
| id |
OLC2075415560 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2075415560</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230402231322.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200820s2003 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00411-003-0210-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2075415560</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)s00411-003-0210-y-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">12</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Göggelmann, W.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2003</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2003</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplastic Transformation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transformation Frequency</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Relative Biological Effectiveness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Target Chromosome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">High Relative Biological Effectiveness</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jacobsen, C.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Panzer, W.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Walsh, L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Roos, H.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmid, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Radiation and environmental biophysics</subfield><subfield code="d">Springer-Verlag, 1974</subfield><subfield code="g">42(2003), 3 vom: Okt., Seite 175-182</subfield><subfield code="w">(DE-627)129308528</subfield><subfield code="w">(DE-600)124987-3</subfield><subfield code="w">(DE-576)014507870</subfield><subfield code="x">0301-634X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:42</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:3</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:175-182</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/s00411-003-0210-y</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2018</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4082</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4277</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">42</subfield><subfield code="j">2003</subfield><subfield code="e">3</subfield><subfield code="c">10</subfield><subfield code="h">175-182</subfield></datafield></record></collection>
|
| author |
Göggelmann, W. |
| spellingShingle |
Göggelmann, W. ddc 570 ssgn 12 fid BIODIV misc Neoplastic Transformation misc Transformation Frequency misc Relative Biological Effectiveness misc Target Chromosome misc High Relative Biological Effectiveness Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| authorStr |
Göggelmann, W. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)129308528 |
| format |
Article |
| dewey-ones |
570 - Life sciences; biology 530 - Physics |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
0301-634X |
| topic_title |
570 530 VZ 12 ssgn BIODIV DE-30 fid Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells Neoplastic Transformation Transformation Frequency Relative Biological Effectiveness Target Chromosome High Relative Biological Effectiveness |
| topic |
ddc 570 ssgn 12 fid BIODIV misc Neoplastic Transformation misc Transformation Frequency misc Relative Biological Effectiveness misc Target Chromosome misc High Relative Biological Effectiveness |
| topic_unstemmed |
ddc 570 ssgn 12 fid BIODIV misc Neoplastic Transformation misc Transformation Frequency misc Relative Biological Effectiveness misc Target Chromosome misc High Relative Biological Effectiveness |
| topic_browse |
ddc 570 ssgn 12 fid BIODIV misc Neoplastic Transformation misc Transformation Frequency misc Relative Biological Effectiveness misc Target Chromosome misc High Relative Biological Effectiveness |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| hierarchy_parent_title |
Radiation and environmental biophysics |
| hierarchy_parent_id |
129308528 |
| dewey-tens |
570 - Life sciences; biology 530 - Physics |
| hierarchy_top_title |
Radiation and environmental biophysics |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 |
| title |
Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| ctrlnum |
(DE-627)OLC2075415560 (DE-He213)s00411-003-0210-y-p |
| title_full |
Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| author_sort |
Göggelmann, W. |
| journal |
Radiation and environmental biophysics |
| journalStr |
Radiation and environmental biophysics |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
500 - Science |
| recordtype |
marc |
| publishDateSort |
2003 |
| contenttype_str_mv |
txt |
| container_start_page |
175 |
| author_browse |
Göggelmann, W. Jacobsen, C. Panzer, W. Walsh, L. Roos, H. Schmid, E. |
| container_volume |
42 |
| class |
570 530 VZ 12 ssgn BIODIV DE-30 fid |
| format_se |
Aufsätze |
| author-letter |
Göggelmann, W. |
| doi_str_mv |
10.1007/s00411-003-0210-y |
| dewey-full |
570 530 |
| title_sort |
re-evaluation of the rbe of 29 kv x-rays (mammography x-rays) relative to 220 kv x-rays using neoplastic transformation of human cgl1-hybrid cells |
| title_auth |
Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| abstract |
Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. © Springer-Verlag 2003 |
| abstractGer |
Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. © Springer-Verlag 2003 |
| abstract_unstemmed |
Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values. © Springer-Verlag 2003 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_40 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4219 GBV_ILN_4277 |
| container_issue |
3 |
| title_short |
Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells |
| url |
https://doi.org/10.1007/s00411-003-0210-y |
| remote_bool |
false |
| author2 |
Jacobsen, C. Panzer, W. Walsh, L. Roos, H. Schmid, E. |
| author2Str |
Jacobsen, C. Panzer, W. Walsh, L. Roos, H. Schmid, E. |
| ppnlink |
129308528 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s00411-003-0210-y |
| up_date |
2024-07-04T01:16:47.405Z |
| _version_ |
1803609238306553856 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">OLC2075415560</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230402231322.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">200820s2003 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00411-003-0210-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC2075415560</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-He213)s00411-003-0210-y-p</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">12</subfield><subfield code="2">ssgn</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Göggelmann, W.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Re-evaluation of the RBE of 29 kV x-rays (mammography x-rays) relative to 220 kV x-rays using neoplastic transformation of human CGL1-hybrid cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2003</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Springer-Verlag 2003</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Neoplastic transformation of human CGL1-hybrid cells was examined after exposure to 29 kV x-rays (mammography x-rays) and conventional 220 kV x-rays. The study was designed to repeat, under well-defined irradiation and culture conditions, an earlier investigation by Frankenberg et al. (Radiat Res, 2002), and to assess the validity of the high RBE values of 29 kV x-rays that had been reported. The experiments with the two types of x-rays were performed simultaneously and shared the same controls. The transformation yields with both radiation qualities were fitted to the linear-quadratic dependence on absorbed dose, and a corresponding analysis was performed for the data earlier obtained by Frankenberg et al. The transformation yields in the present study exceed those in the earlier investigation substantially, and it appears that the difference reflects inadequate feeding conditions of the cell cultures in the early experiments. The standard error bands of the dose response curves are derived and are seen to be considerably more narrow in the present results. The lowest dose of the 29 kV x-rays was 1 Gy in both studies, and at this dose the RBE vs. the conventional x-rays has now been found to be 2 with a 95% confidence interval of 1.4–2.6. The previous result was about 3.2, but the 95% confidence is very broad for these data. The estimated limit at low doses is 3.4 in the present experiments with a confidence interval that extends from less than 2 to large values.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplastic Transformation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transformation Frequency</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Relative Biological Effectiveness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Target Chromosome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">High Relative Biological Effectiveness</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jacobsen, C.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Panzer, W.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Walsh, L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Roos, H.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmid, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Radiation and environmental biophysics</subfield><subfield code="d">Springer-Verlag, 1974</subfield><subfield code="g">42(2003), 3 vom: Okt., Seite 175-182</subfield><subfield code="w">(DE-627)129308528</subfield><subfield code="w">(DE-600)124987-3</subfield><subfield code="w">(DE-576)014507870</subfield><subfield code="x">0301-634X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:42</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:3</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:175-182</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://doi.org/10.1007/s00411-003-0210-y</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2018</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4082</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4277</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">42</subfield><subfield code="j">2003</subfield><subfield code="e">3</subfield><subfield code="c">10</subfield><subfield code="h">175-182</subfield></datafield></record></collection>
|
| score |
7.3998213 |