Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system
Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bertho, Jean-Marc [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag 2010 |
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| Übergeordnetes Werk: |
Enthalten in: Radiation and environmental biophysics - Springer-Verlag, 1974, 49(2010), 2 vom: 16. Feb., Seite 239-248 |
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| Übergeordnetes Werk: |
volume:49 ; year:2010 ; number:2 ; day:16 ; month:02 ; pages:239-248 |
| Links: |
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| DOI / URN: |
10.1007/s00411-010-0267-3 |
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| Katalog-ID: |
OLC2075418616 |
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| 520 | |a Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. | ||
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10.1007/s00411-010-0267-3 doi (DE-627)OLC2075418616 (DE-He213)s00411-010-0267-3-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2010 Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity Chernobyl Accident Hematopoietic System 137Cs Concentration 137Cs Content Louiba, Sonia aut Faure, Marie-Cécile aut Tourlonias, Elie aut Stefani, Johanna aut Siffert, Baptiste aut Paquet, François aut Dublineau, Isabelle aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_21 GBV_ILN_22 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4277 AR 49 2010 2 16 02 239-248 |
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10.1007/s00411-010-0267-3 doi (DE-627)OLC2075418616 (DE-He213)s00411-010-0267-3-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2010 Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity Chernobyl Accident Hematopoietic System 137Cs Concentration 137Cs Content Louiba, Sonia aut Faure, Marie-Cécile aut Tourlonias, Elie aut Stefani, Johanna aut Siffert, Baptiste aut Paquet, François aut Dublineau, Isabelle aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_21 GBV_ILN_22 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4277 AR 49 2010 2 16 02 239-248 |
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10.1007/s00411-010-0267-3 doi (DE-627)OLC2075418616 (DE-He213)s00411-010-0267-3-p DE-627 ger DE-627 rakwb eng 570 530 VZ 12 ssgn BIODIV DE-30 fid Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag 2010 Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity Chernobyl Accident Hematopoietic System 137Cs Concentration 137Cs Content Louiba, Sonia aut Faure, Marie-Cécile aut Tourlonias, Elie aut Stefani, Johanna aut Siffert, Baptiste aut Paquet, François aut Dublineau, Isabelle aut Enthalten in Radiation and environmental biophysics Springer-Verlag, 1974 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)129308528 (DE-600)124987-3 (DE-576)014507870 0301-634X nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OPC-GGO GBV_ILN_21 GBV_ILN_22 GBV_ILN_70 GBV_ILN_2018 GBV_ILN_4012 GBV_ILN_4082 GBV_ILN_4277 AR 49 2010 2 16 02 239-248 |
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Enthalten in Radiation and environmental biophysics 49(2010), 2 vom: 16. Feb., Seite 239-248 volume:49 year:2010 number:2 day:16 month:02 pages:239-248 |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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biodistribution of 137cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. © Springer-Verlag 2010 |
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Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. © Springer-Verlag 2010 |
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Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. © Springer-Verlag 2010 |
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