Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives
Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Ther...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kunze-Szikszay, Nils [verfasserIn] |
|---|
| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021. corrected publication 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Applied microbiology and biotechnology - Springer Berlin Heidelberg, 1984, 105(2021), 16-17 vom: Aug., Seite 6245-6255 |
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| Übergeordnetes Werk: |
volume:105 ; year:2021 ; number:16-17 ; month:08 ; pages:6245-6255 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00253-021-11469-7 |
|---|
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OLC2077318619 |
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| 520 | |a Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. | ||
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| 650 | 4 | |a Volatile organic compounds | |
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10.1007/s00253-021-11469-7 doi (DE-627)OLC2077318619 (DE-He213)s00253-021-11469-7-p DE-627 ger DE-627 rakwb eng 570 VZ 12 ssgn BIODIV DE-30 fid Kunze-Szikszay, Nils verfasserin (orcid)0000-0001-9260-6939 aut Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2021. corrected publication 2021 Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. Bacteria Volatile organic compounds Spectrometry Breath analyses Diagnostics Mass spectrometry Ion mobility spectrometry Euler, Maximilian aut Perl, Thorsten (orcid)0000-0002-9379-5716 aut Enthalten in Applied microbiology and biotechnology Springer Berlin Heidelberg, 1984 105(2021), 16-17 vom: Aug., Seite 6245-6255 (DE-627)129942634 (DE-600)392453-1 (DE-576)015507750 0175-7598 nnns volume:105 year:2021 number:16-17 month:08 pages:6245-6255 https://doi.org/10.1007/s00253-021-11469-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 105 2021 16-17 08 6245-6255 |
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10.1007/s00253-021-11469-7 doi (DE-627)OLC2077318619 (DE-He213)s00253-021-11469-7-p DE-627 ger DE-627 rakwb eng 570 VZ 12 ssgn BIODIV DE-30 fid Kunze-Szikszay, Nils verfasserin (orcid)0000-0001-9260-6939 aut Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2021. corrected publication 2021 Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. Bacteria Volatile organic compounds Spectrometry Breath analyses Diagnostics Mass spectrometry Ion mobility spectrometry Euler, Maximilian aut Perl, Thorsten (orcid)0000-0002-9379-5716 aut Enthalten in Applied microbiology and biotechnology Springer Berlin Heidelberg, 1984 105(2021), 16-17 vom: Aug., Seite 6245-6255 (DE-627)129942634 (DE-600)392453-1 (DE-576)015507750 0175-7598 nnns volume:105 year:2021 number:16-17 month:08 pages:6245-6255 https://doi.org/10.1007/s00253-021-11469-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 105 2021 16-17 08 6245-6255 |
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10.1007/s00253-021-11469-7 doi (DE-627)OLC2077318619 (DE-He213)s00253-021-11469-7-p DE-627 ger DE-627 rakwb eng 570 VZ 12 ssgn BIODIV DE-30 fid Kunze-Szikszay, Nils verfasserin (orcid)0000-0001-9260-6939 aut Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s) 2021. corrected publication 2021 Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. Bacteria Volatile organic compounds Spectrometry Breath analyses Diagnostics Mass spectrometry Ion mobility spectrometry Euler, Maximilian aut Perl, Thorsten (orcid)0000-0002-9379-5716 aut Enthalten in Applied microbiology and biotechnology Springer Berlin Heidelberg, 1984 105(2021), 16-17 vom: Aug., Seite 6245-6255 (DE-627)129942634 (DE-600)392453-1 (DE-576)015507750 0175-7598 nnns volume:105 year:2021 number:16-17 month:08 pages:6245-6255 https://doi.org/10.1007/s00253-021-11469-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 105 2021 16-17 08 6245-6255 |
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Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives |
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Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives |
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Kunze-Szikszay, Nils |
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identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives |
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Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives |
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Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. © The Author(s) 2021. corrected publication 2021 |
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Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. © The Author(s) 2021. corrected publication 2021 |
| abstract_unstemmed |
Abstract Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future. © The Author(s) 2021. corrected publication 2021 |
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Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives |
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