Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold
Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, a...
Ausführliche Beschreibung
Autor*in: |
Prakash, Chander [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Anmerkung: |
© ASM International 2021. corrected publication 2021 |
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Übergeordnetes Werk: |
Enthalten in: Journal of materials engineering and performance - Springer US, 1992, 30(2021), 7 vom: 04. März, Seite 4946-4956 |
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Übergeordnetes Werk: |
volume:30 ; year:2021 ; number:7 ; day:04 ; month:03 ; pages:4946-4956 |
Links: |
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DOI / URN: |
10.1007/s11665-021-05566-x |
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Katalog-ID: |
OLC2079585347 |
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520 | |a Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. | ||
650 | 4 | |a 3D printing | |
650 | 4 | |a hydroxyapatite | |
650 | 4 | |a in vitro bioactivity | |
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700 | 1 | |a Narayan, Roger |4 aut | |
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10.1007/s11665-021-05566-x doi (DE-627)OLC2079585347 (DE-He213)s11665-021-05566-x-p DE-627 ger DE-627 rakwb eng 620 660 670 VZ Prakash, Chander verfasserin aut Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © ASM International 2021. corrected publication 2021 Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. 3D printing hydroxyapatite in vitro bioactivity mechanical properties polylactic acid scaffolds Weibull distribution Singh, Gurminder aut Singh, Sunpreet (orcid)0000-0001-9592-4828 aut Linda, W. L. aut Zheng, H. Y. aut Ramakrishna, Seeram aut Narayan, Roger aut Enthalten in Journal of materials engineering and performance Springer US, 1992 30(2021), 7 vom: 04. März, Seite 4946-4956 (DE-627)131147366 (DE-600)1129075-4 (DE-576)033027250 1059-9495 nnns volume:30 year:2021 number:7 day:04 month:03 pages:4946-4956 https://doi.org/10.1007/s11665-021-05566-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 AR 30 2021 7 04 03 4946-4956 |
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10.1007/s11665-021-05566-x doi (DE-627)OLC2079585347 (DE-He213)s11665-021-05566-x-p DE-627 ger DE-627 rakwb eng 620 660 670 VZ Prakash, Chander verfasserin aut Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © ASM International 2021. corrected publication 2021 Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. 3D printing hydroxyapatite in vitro bioactivity mechanical properties polylactic acid scaffolds Weibull distribution Singh, Gurminder aut Singh, Sunpreet (orcid)0000-0001-9592-4828 aut Linda, W. L. aut Zheng, H. Y. aut Ramakrishna, Seeram aut Narayan, Roger aut Enthalten in Journal of materials engineering and performance Springer US, 1992 30(2021), 7 vom: 04. März, Seite 4946-4956 (DE-627)131147366 (DE-600)1129075-4 (DE-576)033027250 1059-9495 nnns volume:30 year:2021 number:7 day:04 month:03 pages:4946-4956 https://doi.org/10.1007/s11665-021-05566-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 AR 30 2021 7 04 03 4946-4956 |
allfields_unstemmed |
10.1007/s11665-021-05566-x doi (DE-627)OLC2079585347 (DE-He213)s11665-021-05566-x-p DE-627 ger DE-627 rakwb eng 620 660 670 VZ Prakash, Chander verfasserin aut Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © ASM International 2021. corrected publication 2021 Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. 3D printing hydroxyapatite in vitro bioactivity mechanical properties polylactic acid scaffolds Weibull distribution Singh, Gurminder aut Singh, Sunpreet (orcid)0000-0001-9592-4828 aut Linda, W. L. aut Zheng, H. Y. aut Ramakrishna, Seeram aut Narayan, Roger aut Enthalten in Journal of materials engineering and performance Springer US, 1992 30(2021), 7 vom: 04. März, Seite 4946-4956 (DE-627)131147366 (DE-600)1129075-4 (DE-576)033027250 1059-9495 nnns volume:30 year:2021 number:7 day:04 month:03 pages:4946-4956 https://doi.org/10.1007/s11665-021-05566-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 AR 30 2021 7 04 03 4946-4956 |
allfieldsGer |
10.1007/s11665-021-05566-x doi (DE-627)OLC2079585347 (DE-He213)s11665-021-05566-x-p DE-627 ger DE-627 rakwb eng 620 660 670 VZ Prakash, Chander verfasserin aut Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © ASM International 2021. corrected publication 2021 Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. 3D printing hydroxyapatite in vitro bioactivity mechanical properties polylactic acid scaffolds Weibull distribution Singh, Gurminder aut Singh, Sunpreet (orcid)0000-0001-9592-4828 aut Linda, W. L. aut Zheng, H. Y. aut Ramakrishna, Seeram aut Narayan, Roger aut Enthalten in Journal of materials engineering and performance Springer US, 1992 30(2021), 7 vom: 04. März, Seite 4946-4956 (DE-627)131147366 (DE-600)1129075-4 (DE-576)033027250 1059-9495 nnns volume:30 year:2021 number:7 day:04 month:03 pages:4946-4956 https://doi.org/10.1007/s11665-021-05566-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 AR 30 2021 7 04 03 4946-4956 |
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10.1007/s11665-021-05566-x doi (DE-627)OLC2079585347 (DE-He213)s11665-021-05566-x-p DE-627 ger DE-627 rakwb eng 620 660 670 VZ Prakash, Chander verfasserin aut Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © ASM International 2021. corrected publication 2021 Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. 3D printing hydroxyapatite in vitro bioactivity mechanical properties polylactic acid scaffolds Weibull distribution Singh, Gurminder aut Singh, Sunpreet (orcid)0000-0001-9592-4828 aut Linda, W. L. aut Zheng, H. Y. aut Ramakrishna, Seeram aut Narayan, Roger aut Enthalten in Journal of materials engineering and performance Springer US, 1992 30(2021), 7 vom: 04. März, Seite 4946-4956 (DE-627)131147366 (DE-600)1129075-4 (DE-576)033027250 1059-9495 nnns volume:30 year:2021 number:7 day:04 month:03 pages:4946-4956 https://doi.org/10.1007/s11665-021-05566-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 AR 30 2021 7 04 03 4946-4956 |
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Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold |
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Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold |
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Prakash, Chander |
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Prakash, Chander Singh, Gurminder Singh, Sunpreet Linda, W. L. Zheng, H. Y. Ramakrishna, Seeram Narayan, Roger |
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mechanical reliability and in vitro bioactivity of 3d-printed porous polylactic acid-hydroxyapatite scaffold |
title_auth |
Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold |
abstract |
Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. © ASM International 2021. corrected publication 2021 |
abstractGer |
Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. © ASM International 2021. corrected publication 2021 |
abstract_unstemmed |
Abstract The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications. © ASM International 2021. corrected publication 2021 |
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title_short |
Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold |
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https://doi.org/10.1007/s11665-021-05566-x |
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Singh, Gurminder Singh, Sunpreet Linda, W. L. Zheng, H. Y. Ramakrishna, Seeram Narayan, Roger |
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