Experimental and thermodynamic study of solubility, partition and solvation of climbazole
Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Blokhina, Svetlana [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Akadémiai Kiadó, Budapest, Hungary 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of thermal analysis and calorimetry - Springer International Publishing, 1998, 147(2022), 21 vom: 28. Juni, Seite 11977-11989 |
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| Übergeordnetes Werk: |
volume:147 ; year:2022 ; number:21 ; day:28 ; month:06 ; pages:11977-11989 |
| Links: |
|---|
| DOI / URN: |
10.1007/s10973-022-11426-0 |
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OLC2079635948 |
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| 520 | |a Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. | ||
| 650 | 4 | |a Climbazole | |
| 650 | 4 | |a Solubility | |
| 650 | 4 | |a Molar heat capacity | |
| 650 | 4 | |a Partition coefficient | |
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| 700 | 1 | |a Ol’khovich, Marina |0 (orcid)0000-0003-2680-240X |4 aut | |
| 700 | 1 | |a Perlovich, German |0 (orcid)0000-0002-6267-5244 |4 aut | |
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10.1007/s10973-022-11426-0 doi (DE-627)OLC2079635948 (DE-He213)s10973-022-11426-0-p DE-627 ger DE-627 rakwb eng 660 VZ Blokhina, Svetlana verfasserin (orcid)0000-0003-3492-6808 aut Experimental and thermodynamic study of solubility, partition and solvation of climbazole 2022 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Akadémiai Kiadó, Budapest, Hungary 2022 Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. Climbazole Solubility Molar heat capacity Partition coefficient Solvation Thermodynamic properties Sharapova, Angelica (orcid)0000-0003-3883-3190 aut Ol’khovich, Marina (orcid)0000-0003-2680-240X aut Perlovich, German (orcid)0000-0002-6267-5244 aut Enthalten in Journal of thermal analysis and calorimetry Springer International Publishing, 1998 147(2022), 21 vom: 28. Juni, Seite 11977-11989 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:147 year:2022 number:21 day:28 month:06 pages:11977-11989 https://doi.org/10.1007/s10973-022-11426-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 147 2022 21 28 06 11977-11989 |
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10.1007/s10973-022-11426-0 doi (DE-627)OLC2079635948 (DE-He213)s10973-022-11426-0-p DE-627 ger DE-627 rakwb eng 660 VZ Blokhina, Svetlana verfasserin (orcid)0000-0003-3492-6808 aut Experimental and thermodynamic study of solubility, partition and solvation of climbazole 2022 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Akadémiai Kiadó, Budapest, Hungary 2022 Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. Climbazole Solubility Molar heat capacity Partition coefficient Solvation Thermodynamic properties Sharapova, Angelica (orcid)0000-0003-3883-3190 aut Ol’khovich, Marina (orcid)0000-0003-2680-240X aut Perlovich, German (orcid)0000-0002-6267-5244 aut Enthalten in Journal of thermal analysis and calorimetry Springer International Publishing, 1998 147(2022), 21 vom: 28. Juni, Seite 11977-11989 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:147 year:2022 number:21 day:28 month:06 pages:11977-11989 https://doi.org/10.1007/s10973-022-11426-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 147 2022 21 28 06 11977-11989 |
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10.1007/s10973-022-11426-0 doi (DE-627)OLC2079635948 (DE-He213)s10973-022-11426-0-p DE-627 ger DE-627 rakwb eng 660 VZ Blokhina, Svetlana verfasserin (orcid)0000-0003-3492-6808 aut Experimental and thermodynamic study of solubility, partition and solvation of climbazole 2022 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Akadémiai Kiadó, Budapest, Hungary 2022 Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. Climbazole Solubility Molar heat capacity Partition coefficient Solvation Thermodynamic properties Sharapova, Angelica (orcid)0000-0003-3883-3190 aut Ol’khovich, Marina (orcid)0000-0003-2680-240X aut Perlovich, German (orcid)0000-0002-6267-5244 aut Enthalten in Journal of thermal analysis and calorimetry Springer International Publishing, 1998 147(2022), 21 vom: 28. Juni, Seite 11977-11989 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:147 year:2022 number:21 day:28 month:06 pages:11977-11989 https://doi.org/10.1007/s10973-022-11426-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 147 2022 21 28 06 11977-11989 |
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10.1007/s10973-022-11426-0 doi (DE-627)OLC2079635948 (DE-He213)s10973-022-11426-0-p DE-627 ger DE-627 rakwb eng 660 VZ Blokhina, Svetlana verfasserin (orcid)0000-0003-3492-6808 aut Experimental and thermodynamic study of solubility, partition and solvation of climbazole 2022 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Akadémiai Kiadó, Budapest, Hungary 2022 Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. Climbazole Solubility Molar heat capacity Partition coefficient Solvation Thermodynamic properties Sharapova, Angelica (orcid)0000-0003-3883-3190 aut Ol’khovich, Marina (orcid)0000-0003-2680-240X aut Perlovich, German (orcid)0000-0002-6267-5244 aut Enthalten in Journal of thermal analysis and calorimetry Springer International Publishing, 1998 147(2022), 21 vom: 28. Juni, Seite 11977-11989 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:147 year:2022 number:21 day:28 month:06 pages:11977-11989 https://doi.org/10.1007/s10973-022-11426-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 147 2022 21 28 06 11977-11989 |
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10.1007/s10973-022-11426-0 doi (DE-627)OLC2079635948 (DE-He213)s10973-022-11426-0-p DE-627 ger DE-627 rakwb eng 660 VZ Blokhina, Svetlana verfasserin (orcid)0000-0003-3492-6808 aut Experimental and thermodynamic study of solubility, partition and solvation of climbazole 2022 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Akadémiai Kiadó, Budapest, Hungary 2022 Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. Climbazole Solubility Molar heat capacity Partition coefficient Solvation Thermodynamic properties Sharapova, Angelica (orcid)0000-0003-3883-3190 aut Ol’khovich, Marina (orcid)0000-0003-2680-240X aut Perlovich, German (orcid)0000-0002-6267-5244 aut Enthalten in Journal of thermal analysis and calorimetry Springer International Publishing, 1998 147(2022), 21 vom: 28. Juni, Seite 11977-11989 (DE-627)244148767 (DE-600)1429493-X (DE-576)066397693 1388-6150 nnns volume:147 year:2022 number:21 day:28 month:06 pages:11977-11989 https://doi.org/10.1007/s10973-022-11426-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 AR 147 2022 21 28 06 11977-11989 |
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| title_sort |
experimental and thermodynamic study of solubility, partition and solvation of climbazole |
| title_auth |
Experimental and thermodynamic study of solubility, partition and solvation of climbazole |
| abstract |
Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. © Akadémiai Kiadó, Budapest, Hungary 2022 |
| abstractGer |
Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. © Akadémiai Kiadó, Budapest, Hungary 2022 |
| abstract_unstemmed |
Abstract The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement. © Akadémiai Kiadó, Budapest, Hungary 2022 |
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| title_short |
Experimental and thermodynamic study of solubility, partition and solvation of climbazole |
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https://doi.org/10.1007/s10973-022-11426-0 |
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| author2 |
Sharapova, Angelica Ol’khovich, Marina Perlovich, German |
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Sharapova, Angelica Ol’khovich, Marina Perlovich, German |
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| doi_str |
10.1007/s10973-022-11426-0 |
| up_date |
2024-07-04T01:37:04.578Z |
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