Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release

Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sirois, P. [verfasserIn] Cadieux, A. Rola-Pleszczynski, M. Bégin, R.

Format:	Artikel
Sprache:	Englisch

Erschienen:	1982

Schlagwörter:	Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage

Anmerkung:	© Birkhäuser Verlag 1982

Übergeordnetes Werk:	Enthalten in: Experientia - Birkhäuser-Verlag, 1945, 38(1982), 9 vom: 01. Sept., Seite 1125-1127
Übergeordnetes Werk:	volume:38 ; year:1982 ; number:9 ; day:01 ; month:09 ; pages:1125-1127

Links:	Volltext

DOI / URN:	10.1007/BF01955404

Katalog-ID:	OLC2080710060

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520			\|a Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants.
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allfields	10.1007/BF01955404 doi (DE-627)OLC2080710060 (DE-He213)BF01955404-p DE-627 ger DE-627 rakwb eng 500 610 VZ Sirois, P. verfasserin aut Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1982 Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage Cadieux, A. aut Rola-Pleszczynski, M. aut Bégin, R. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 38(1982), 9 vom: 01. Sept., Seite 1125-1127 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127 https://doi.org/10.1007/BF01955404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 38 1982 9 01 09 1125-1127
spelling	10.1007/BF01955404 doi (DE-627)OLC2080710060 (DE-He213)BF01955404-p DE-627 ger DE-627 rakwb eng 500 610 VZ Sirois, P. verfasserin aut Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1982 Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage Cadieux, A. aut Rola-Pleszczynski, M. aut Bégin, R. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 38(1982), 9 vom: 01. Sept., Seite 1125-1127 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127 https://doi.org/10.1007/BF01955404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 38 1982 9 01 09 1125-1127
allfields_unstemmed	10.1007/BF01955404 doi (DE-627)OLC2080710060 (DE-He213)BF01955404-p DE-627 ger DE-627 rakwb eng 500 610 VZ Sirois, P. verfasserin aut Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1982 Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage Cadieux, A. aut Rola-Pleszczynski, M. aut Bégin, R. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 38(1982), 9 vom: 01. Sept., Seite 1125-1127 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127 https://doi.org/10.1007/BF01955404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 38 1982 9 01 09 1125-1127
allfieldsGer	10.1007/BF01955404 doi (DE-627)OLC2080710060 (DE-He213)BF01955404-p DE-627 ger DE-627 rakwb eng 500 610 VZ Sirois, P. verfasserin aut Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1982 Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage Cadieux, A. aut Rola-Pleszczynski, M. aut Bégin, R. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 38(1982), 9 vom: 01. Sept., Seite 1125-1127 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127 https://doi.org/10.1007/BF01955404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 38 1982 9 01 09 1125-1127
allfieldsSound	10.1007/BF01955404 doi (DE-627)OLC2080710060 (DE-He213)BF01955404-p DE-627 ger DE-627 rakwb eng 500 610 VZ Sirois, P. verfasserin aut Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1982 Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage Cadieux, A. aut Rola-Pleszczynski, M. aut Bégin, R. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 38(1982), 9 vom: 01. Sept., Seite 1125-1127 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127 https://doi.org/10.1007/BF01955404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 38 1982 9 01 09 1125-1127
language	English
source	Enthalten in Experientia 38(1982), 9 vom: 01. Sept., Seite 1125-1127 volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127
sourceStr	Enthalten in Experientia 38(1982), 9 vom: 01. Sept., Seite 1125-1127 volume:38 year:1982 number:9 day:01 month:09 pages:1125-1127
format_phy_str_mv	Article
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topic_facet	Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage
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author	Sirois, P.
spellingShingle	Sirois, P. ddc 500 misc Prostaglandin misc Indomethacin misc Defense Mechanism misc Inflammatory Reaction misc Alveolar Macrophage Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release
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topic_title	500 610 VZ Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release Prostaglandin Indomethacin Defense Mechanism Inflammatory Reaction Alveolar Macrophage
topic	ddc 500 misc Prostaglandin misc Indomethacin misc Defense Mechanism misc Inflammatory Reaction misc Alveolar Macrophage
topic_unstemmed	ddc 500 misc Prostaglandin misc Indomethacin misc Defense Mechanism misc Inflammatory Reaction misc Alveolar Macrophage
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title	Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release
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title_full	Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release
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title_sort	perifused alveolar macrophages. a technique to study the effects of toxicants on prostaglandin release
title_auth	Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release
abstract	Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. © Birkhäuser Verlag 1982
abstractGer	Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. © Birkhäuser Verlag 1982
abstract_unstemmed	Summary A technique was developed for perfusing free airway cells (FAC) obtained by guinea-pig bronchoalveolar lavage. 10×$ 10^{6} $ FAC (mostly macrophages) were placed on the filter of a Nuclepore chamber perfused with Tyrode's solution or with Eagle's Minimal Essential Medium (MEM); the effluent was collected at intervals and the release of prostaglandin $ E_{2} $ by the perifused cells was used as an index of the inflammatory reaction to toxicants. Zymosan, asbestos fibers and soluble toxic agents stimulated the synthesis of prostaglandins while indomethacin abolished it. Our technique of FAC perifusion allows the sequential study of biochemical events involved in macrophage defense mechanisms as well as providing a simple test for the evaluation of various toxicants. © Birkhäuser Verlag 1982
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title_short	Perifused alveolar macrophages. A technique to study the effects of toxicants on prostaglandin release
url	https://doi.org/10.1007/BF01955404
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author2	Cadieux, A. Rola-Pleszczynski, M. Bégin, R.
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