Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation

Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-ver...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nissen, C. [verfasserIn] Gratwohl, A. Tichelli, A. Speck, B.

Format:	Artikel
Sprache:	Englisch

Erschienen:	1988

Anmerkung:	© Birkhäuser Verlag 1988

Übergeordnetes Werk:	Enthalten in: Experientia - Birkhäuser-Verlag, 1945, 44(1988), 2 vom: 01. Feb., Seite 167-169
Übergeordnetes Werk:	volume:44 ; year:1988 ; number:2 ; day:01 ; month:02 ; pages:167-169

Links:	Volltext

DOI / URN:	10.1007/BF01952204

Katalog-ID:	OLC2080737155

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520			\|a Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML.
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allfields	10.1007/BF01952204 doi (DE-627)OLC2080737155 (DE-He213)BF01952204-p DE-627 ger DE-627 rakwb eng 500 610 VZ Nissen, C. verfasserin aut Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation 1988 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1988 Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. Gratwohl, A. aut Tichelli, A. aut Speck, B. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 44(1988), 2 vom: 01. Feb., Seite 167-169 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:44 year:1988 number:2 day:01 month:02 pages:167-169 https://doi.org/10.1007/BF01952204 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 44 1988 2 01 02 167-169
spelling	10.1007/BF01952204 doi (DE-627)OLC2080737155 (DE-He213)BF01952204-p DE-627 ger DE-627 rakwb eng 500 610 VZ Nissen, C. verfasserin aut Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation 1988 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1988 Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. Gratwohl, A. aut Tichelli, A. aut Speck, B. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 44(1988), 2 vom: 01. Feb., Seite 167-169 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:44 year:1988 number:2 day:01 month:02 pages:167-169 https://doi.org/10.1007/BF01952204 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 44 1988 2 01 02 167-169
allfields_unstemmed	10.1007/BF01952204 doi (DE-627)OLC2080737155 (DE-He213)BF01952204-p DE-627 ger DE-627 rakwb eng 500 610 VZ Nissen, C. verfasserin aut Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation 1988 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1988 Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. Gratwohl, A. aut Tichelli, A. aut Speck, B. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 44(1988), 2 vom: 01. Feb., Seite 167-169 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:44 year:1988 number:2 day:01 month:02 pages:167-169 https://doi.org/10.1007/BF01952204 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 44 1988 2 01 02 167-169
allfieldsGer	10.1007/BF01952204 doi (DE-627)OLC2080737155 (DE-He213)BF01952204-p DE-627 ger DE-627 rakwb eng 500 610 VZ Nissen, C. verfasserin aut Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation 1988 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1988 Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. Gratwohl, A. aut Tichelli, A. aut Speck, B. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 44(1988), 2 vom: 01. Feb., Seite 167-169 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:44 year:1988 number:2 day:01 month:02 pages:167-169 https://doi.org/10.1007/BF01952204 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 44 1988 2 01 02 167-169
allfieldsSound	10.1007/BF01952204 doi (DE-627)OLC2080737155 (DE-He213)BF01952204-p DE-627 ger DE-627 rakwb eng 500 610 VZ Nissen, C. verfasserin aut Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation 1988 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Birkhäuser Verlag 1988 Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. Gratwohl, A. aut Tichelli, A. aut Speck, B. aut Enthalten in Experientia Birkhäuser-Verlag, 1945 44(1988), 2 vom: 01. Feb., Seite 167-169 (DE-627)129070955 (DE-600)1972-0 (DE-576)014402912 0014-4754 nnns volume:44 year:1988 number:2 day:01 month:02 pages:167-169 https://doi.org/10.1007/BF01952204 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_105 GBV_ILN_171 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_2004 GBV_ILN_2006 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2221 GBV_ILN_2360 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4319 GBV_ILN_4323 AR 44 1988 2 01 02 167-169
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author	Nissen, C.
spellingShingle	Nissen, C. ddc 500 Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
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topic_title	500 610 VZ Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
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title	Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
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title_full	Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
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title_sort	abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for graft-versus-host disease after bone marrow transplantation
title_auth	Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
abstract	Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. © Birkhäuser Verlag 1988
abstractGer	Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. © Birkhäuser Verlag 1988
abstract_unstemmed	Summary Peripheral blood cultures of hemopoietic precursor cells from 30 patients with chronic myelogenous leukemia showed different growth patterns before bone marrow transplantation. A strong increase of free and clustered macrophages was seen in 11/30. Of these 11 patients, 10 developed Graft-versus-Host Disease (GvHD). Of 19 patients without the macrophage pattern, 4 developed GvHD (p=0.004). Of 14 patients with GvHD, 10 had shown the macrophage pattern before bone marrow transplantation, compared to 1/19 without GvHD (p=0.004). We postulate that excess macrophages in the bone marrow recipient trigger GvHD by enhancing presentation of recipient antigens to donor T-lymphocytes, and that their presence is predictive of GvHD in CML. © Birkhäuser Verlag 1988
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title_short	Abundant macrophage growth in culture from patients with chronic myelogenous leukemia: a risk factor for Graft-versus-Host Disease after bone marrow transplantation
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