DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands
Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes sho...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zeng, Pengfei [verfasserIn] |
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| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer International Publishing Switzerland 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Transition metal chemistry - Springer International Publishing, 1975, 40(2015), 8 vom: 09. Sept., Seite 779-787 |
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| Übergeordnetes Werk: |
volume:40 ; year:2015 ; number:8 ; day:09 ; month:09 ; pages:779-787 |
| Links: |
|---|
| DOI / URN: |
10.1007/s11243-015-9939-9 |
|---|
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OLC2084053471 |
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| 520 | |a Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. | ||
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| 700 | 1 | |a Lu, Jiazheng |4 aut | |
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10.1007/s11243-015-9939-9 doi (DE-627)OLC2084053471 (DE-He213)s11243-015-9939-9-p DE-627 ger DE-627 rakwb eng 660 VZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer International Publishing Switzerland 2015 Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Schiff Base Acac Free Ligand Schiff Base Ligand Intrinsic Binding Constant He, Limin aut Ye, Zhenfeng aut Yang, Ning aut Song, Yulan aut Lu, Jiazheng aut Enthalten in Transition metal chemistry Springer International Publishing, 1975 40(2015), 8 vom: 09. Sept., Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 day:09 month:09 pages:779-787 https://doi.org/10.1007/s11243-015-9939-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 09 09 779-787 |
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10.1007/s11243-015-9939-9 doi (DE-627)OLC2084053471 (DE-He213)s11243-015-9939-9-p DE-627 ger DE-627 rakwb eng 660 VZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer International Publishing Switzerland 2015 Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Schiff Base Acac Free Ligand Schiff Base Ligand Intrinsic Binding Constant He, Limin aut Ye, Zhenfeng aut Yang, Ning aut Song, Yulan aut Lu, Jiazheng aut Enthalten in Transition metal chemistry Springer International Publishing, 1975 40(2015), 8 vom: 09. Sept., Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 day:09 month:09 pages:779-787 https://doi.org/10.1007/s11243-015-9939-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 09 09 779-787 |
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10.1007/s11243-015-9939-9 doi (DE-627)OLC2084053471 (DE-He213)s11243-015-9939-9-p DE-627 ger DE-627 rakwb eng 660 VZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer International Publishing Switzerland 2015 Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Schiff Base Acac Free Ligand Schiff Base Ligand Intrinsic Binding Constant He, Limin aut Ye, Zhenfeng aut Yang, Ning aut Song, Yulan aut Lu, Jiazheng aut Enthalten in Transition metal chemistry Springer International Publishing, 1975 40(2015), 8 vom: 09. Sept., Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 day:09 month:09 pages:779-787 https://doi.org/10.1007/s11243-015-9939-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 09 09 779-787 |
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10.1007/s11243-015-9939-9 doi (DE-627)OLC2084053471 (DE-He213)s11243-015-9939-9-p DE-627 ger DE-627 rakwb eng 660 VZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer International Publishing Switzerland 2015 Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Schiff Base Acac Free Ligand Schiff Base Ligand Intrinsic Binding Constant He, Limin aut Ye, Zhenfeng aut Yang, Ning aut Song, Yulan aut Lu, Jiazheng aut Enthalten in Transition metal chemistry Springer International Publishing, 1975 40(2015), 8 vom: 09. Sept., Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 day:09 month:09 pages:779-787 https://doi.org/10.1007/s11243-015-9939-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 09 09 779-787 |
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10.1007/s11243-015-9939-9 doi (DE-627)OLC2084053471 (DE-He213)s11243-015-9939-9-p DE-627 ger DE-627 rakwb eng 660 VZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer International Publishing Switzerland 2015 Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Schiff Base Acac Free Ligand Schiff Base Ligand Intrinsic Binding Constant He, Limin aut Ye, Zhenfeng aut Yang, Ning aut Song, Yulan aut Lu, Jiazheng aut Enthalten in Transition metal chemistry Springer International Publishing, 1975 40(2015), 8 vom: 09. Sept., Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 day:09 month:09 pages:779-787 https://doi.org/10.1007/s11243-015-9939-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 09 09 779-787 |
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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
| abstract |
Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. © Springer International Publishing Switzerland 2015 |
| abstractGer |
Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. © Springer International Publishing Switzerland 2015 |
| abstract_unstemmed |
Abstract Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. © Springer International Publishing Switzerland 2015 |
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| container_issue |
8 |
| title_short |
DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
| url |
https://doi.org/10.1007/s11243-015-9939-9 |
| remote_bool |
false |
| author2 |
He, Limin Ye, Zhenfeng Yang, Ning Song, Yulan Lu, Jiazheng |
| author2Str |
He, Limin Ye, Zhenfeng Yang, Ning Song, Yulan Lu, Jiazheng |
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129605417 |
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| doi_str |
10.1007/s11243-015-9939-9 |
| up_date |
2024-07-04T01:21:10.955Z |
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1803609514696507392 |
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7.4005365 |