Determination of dependence of binding parameters on receptor occupancy
Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rescigno, Aldo [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1982 |
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| Schlagwörter: |
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| Anmerkung: |
© Society for Mathematical Biology 1982 |
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| Übergeordnetes Werk: |
Enthalten in: Bulletin of mathematical biology - Kluwer Academic Publishers, 1973, 44(1982), 4 vom: Juli, Seite 477-489 |
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| Übergeordnetes Werk: |
volume:44 ; year:1982 ; number:4 ; month:07 ; pages:477-489 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF02459404 |
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| Katalog-ID: |
OLC2087060789 |
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| 520 | |a Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. | ||
| 650 | 4 | |a Receptor Occupancy | |
| 650 | 4 | |a Equilibrium Measurement | |
| 650 | 4 | |a Binding Parameter | |
| 650 | 4 | |a Dissociation Rate Constant | |
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| 700 | 1 | |a Goren, H. Joseph |4 aut | |
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10.1007/BF02459404 doi (DE-627)OLC2087060789 (DE-He213)BF02459404-p DE-627 ger DE-627 rakwb eng 570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Rescigno, Aldo verfasserin aut Determination of dependence of binding parameters on receptor occupancy 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Society for Mathematical Biology 1982 Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel Beck, James S. aut Goren, H. Joseph aut Enthalten in Bulletin of mathematical biology Kluwer Academic Publishers, 1973 44(1982), 4 vom: Juli, Seite 477-489 (DE-627)129391719 (DE-600)184905-0 (DE-576)014776863 0092-8240 nnns volume:44 year:1982 number:4 month:07 pages:477-489 https://doi.org/10.1007/BF02459404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_24 GBV_ILN_40 GBV_ILN_65 GBV_ILN_70 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4219 GBV_ILN_4310 GBV_ILN_4323 42.00 VZ AR 44 1982 4 07 477-489 |
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10.1007/BF02459404 doi (DE-627)OLC2087060789 (DE-He213)BF02459404-p DE-627 ger DE-627 rakwb eng 570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Rescigno, Aldo verfasserin aut Determination of dependence of binding parameters on receptor occupancy 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Society for Mathematical Biology 1982 Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel Beck, James S. aut Goren, H. Joseph aut Enthalten in Bulletin of mathematical biology Kluwer Academic Publishers, 1973 44(1982), 4 vom: Juli, Seite 477-489 (DE-627)129391719 (DE-600)184905-0 (DE-576)014776863 0092-8240 nnns volume:44 year:1982 number:4 month:07 pages:477-489 https://doi.org/10.1007/BF02459404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_24 GBV_ILN_40 GBV_ILN_65 GBV_ILN_70 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4219 GBV_ILN_4310 GBV_ILN_4323 42.00 VZ AR 44 1982 4 07 477-489 |
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10.1007/BF02459404 doi (DE-627)OLC2087060789 (DE-He213)BF02459404-p DE-627 ger DE-627 rakwb eng 570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Rescigno, Aldo verfasserin aut Determination of dependence of binding parameters on receptor occupancy 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Society for Mathematical Biology 1982 Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel Beck, James S. aut Goren, H. Joseph aut Enthalten in Bulletin of mathematical biology Kluwer Academic Publishers, 1973 44(1982), 4 vom: Juli, Seite 477-489 (DE-627)129391719 (DE-600)184905-0 (DE-576)014776863 0092-8240 nnns volume:44 year:1982 number:4 month:07 pages:477-489 https://doi.org/10.1007/BF02459404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_24 GBV_ILN_40 GBV_ILN_65 GBV_ILN_70 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4219 GBV_ILN_4310 GBV_ILN_4323 42.00 VZ AR 44 1982 4 07 477-489 |
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10.1007/BF02459404 doi (DE-627)OLC2087060789 (DE-He213)BF02459404-p DE-627 ger DE-627 rakwb eng 570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Rescigno, Aldo verfasserin aut Determination of dependence of binding parameters on receptor occupancy 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Society for Mathematical Biology 1982 Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel Beck, James S. aut Goren, H. Joseph aut Enthalten in Bulletin of mathematical biology Kluwer Academic Publishers, 1973 44(1982), 4 vom: Juli, Seite 477-489 (DE-627)129391719 (DE-600)184905-0 (DE-576)014776863 0092-8240 nnns volume:44 year:1982 number:4 month:07 pages:477-489 https://doi.org/10.1007/BF02459404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_24 GBV_ILN_40 GBV_ILN_65 GBV_ILN_70 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4219 GBV_ILN_4310 GBV_ILN_4323 42.00 VZ AR 44 1982 4 07 477-489 |
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10.1007/BF02459404 doi (DE-627)OLC2087060789 (DE-He213)BF02459404-p DE-627 ger DE-627 rakwb eng 570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Rescigno, Aldo verfasserin aut Determination of dependence of binding parameters on receptor occupancy 1982 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Society for Mathematical Biology 1982 Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel Beck, James S. aut Goren, H. Joseph aut Enthalten in Bulletin of mathematical biology Kluwer Academic Publishers, 1973 44(1982), 4 vom: Juli, Seite 477-489 (DE-627)129391719 (DE-600)184905-0 (DE-576)014776863 0092-8240 nnns volume:44 year:1982 number:4 month:07 pages:477-489 https://doi.org/10.1007/BF02459404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-MAT SSG-OPC-MAT GBV_ILN_11 GBV_ILN_21 GBV_ILN_24 GBV_ILN_40 GBV_ILN_65 GBV_ILN_70 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2021 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4219 GBV_ILN_4310 GBV_ILN_4323 42.00 VZ AR 44 1982 4 07 477-489 |
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570 510 VZ 12 ssgn BIODIV DE-30 fid 42.00 bkl Determination of dependence of binding parameters on receptor occupancy Receptor Occupancy Equilibrium Measurement Binding Parameter Dissociation Rate Constant Straight Line Parallel |
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Determination of dependence of binding parameters on receptor occupancy |
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Determination of dependence of binding parameters on receptor occupancy |
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determination of dependence of binding parameters on receptor occupancy |
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Determination of dependence of binding parameters on receptor occupancy |
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Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. © Society for Mathematical Biology 1982 |
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Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. © Society for Mathematical Biology 1982 |
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Abstract Measurements of the binding of ligand to receptors that are macromolecules, either free or components of biomembranes, often show deviation from what is expected of a simple reaction described by an association and a dissociation rate constant. A more versatile model and more discriminating experiments are required for a satisfactory explanation. This paper is based on a general model of the binding reaction in which the rate constants and equilibrium constant are dependent upon occupancy of receptors. The analysis of the model leads to three kinds of experiments: (1) equilibrium measurements which permit quantitative determination of a dissociation equilibrium parameter as a function of receptor occupancy; (2) measurements prior to equilibrium which yield the same information; and (3) measurements prior to equilibrium which reveal quantitatively the dependence of both association and dissociation rate parameters separately, on occupancy. © Society for Mathematical Biology 1982 |
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