Improved mass accuracy for tandem mass spectrometry
Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perfor...
Ausführliche Beschreibung
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| Autor*in: |
Kaiser, Nathan K. [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2005 |
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| Schlagwörter: |
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| Anmerkung: |
© American Society for Mass Spectrometry 2004 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of the American Society for Mass Spectrometry - Springer-Verlag, 1990, 16(2005), 4 vom: 01. Apr., Seite 463-470 |
|---|---|
| Übergeordnetes Werk: |
volume:16 ; year:2005 ; number:4 ; day:01 ; month:04 ; pages:463-470 |
| Links: |
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| DOI / URN: |
10.1016/j.jasms.2004.12.005 |
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| 520 | |a Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. | ||
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10.1016/j.jasms.2004.12.005 doi (DE-627)OLC209766279X (DE-He213)j.jasms.2004.12.005-p DE-627 ger DE-627 rakwb eng 530 VZ 11 ssgn Kaiser, Nathan K. verfasserin aut Improved mass accuracy for tandem mass spectrometry 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © American Society for Mass Spectrometry 2004 Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. Mass Accuracy Electron Capture Dissociation Electron Transfer Dissociation Space Charge Effect Fourier Transform Mass Spectrometry Anderson, Gordon A. aut Bruce, James E. aut Enthalten in Journal of the American Society for Mass Spectrometry Springer-Verlag, 1990 16(2005), 4 vom: 01. Apr., Seite 463-470 (DE-627)130977357 (DE-600)1073671-2 (DE-576)277732093 1044-0305 nnns volume:16 year:2005 number:4 day:01 month:04 pages:463-470 https://doi.org/10.1016/j.jasms.2004.12.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE GBV_ILN_40 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4307 GBV_ILN_4313 AR 16 2005 4 01 04 463-470 |
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10.1016/j.jasms.2004.12.005 doi (DE-627)OLC209766279X (DE-He213)j.jasms.2004.12.005-p DE-627 ger DE-627 rakwb eng 530 VZ 11 ssgn Kaiser, Nathan K. verfasserin aut Improved mass accuracy for tandem mass spectrometry 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © American Society for Mass Spectrometry 2004 Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. Mass Accuracy Electron Capture Dissociation Electron Transfer Dissociation Space Charge Effect Fourier Transform Mass Spectrometry Anderson, Gordon A. aut Bruce, James E. aut Enthalten in Journal of the American Society for Mass Spectrometry Springer-Verlag, 1990 16(2005), 4 vom: 01. Apr., Seite 463-470 (DE-627)130977357 (DE-600)1073671-2 (DE-576)277732093 1044-0305 nnns volume:16 year:2005 number:4 day:01 month:04 pages:463-470 https://doi.org/10.1016/j.jasms.2004.12.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE GBV_ILN_40 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4307 GBV_ILN_4313 AR 16 2005 4 01 04 463-470 |
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10.1016/j.jasms.2004.12.005 doi (DE-627)OLC209766279X (DE-He213)j.jasms.2004.12.005-p DE-627 ger DE-627 rakwb eng 530 VZ 11 ssgn Kaiser, Nathan K. verfasserin aut Improved mass accuracy for tandem mass spectrometry 2005 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © American Society for Mass Spectrometry 2004 Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. Mass Accuracy Electron Capture Dissociation Electron Transfer Dissociation Space Charge Effect Fourier Transform Mass Spectrometry Anderson, Gordon A. aut Bruce, James E. aut Enthalten in Journal of the American Society for Mass Spectrometry Springer-Verlag, 1990 16(2005), 4 vom: 01. Apr., Seite 463-470 (DE-627)130977357 (DE-600)1073671-2 (DE-576)277732093 1044-0305 nnns volume:16 year:2005 number:4 day:01 month:04 pages:463-470 https://doi.org/10.1016/j.jasms.2004.12.005 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE GBV_ILN_40 GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4307 GBV_ILN_4313 AR 16 2005 4 01 04 463-470 |
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Improved mass accuracy for tandem mass spectrometry |
| abstract |
Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. © American Society for Mass Spectrometry 2004 |
| abstractGer |
Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. © American Society for Mass Spectrometry 2004 |
| abstract_unstemmed |
Abstract With the emergence of top-down proteomics, the ability to achieve high mass measurement accuracy on tandem MS/MS data will be beneficial for protein identification and characterization. (FT-ICR) Fourier transform ion cyclotron resonance mass spectrometers are the ideal instruments to perform these experiments with their ability to provide high resolution and mass accuracy. A major limitation to mass measurement accuracy in FT-ICR instruments arises from the occurrence of space charge effects. These space charge effects shift the cyclotron frequency of the ions, which compromises the mass measurement accuracy. While several methods have been developed that correct these space charge effects, they have limitations when applied to MS/MS experiments. It has already been shown that additional information inherent in electrospray spectra can be used for improved mass measurement accuracy with the use of a computer algorithm called DeCAL (deconvolution of Coulombic affected linearity). This paper highlights a new application of the strategy for improved mass accuracy in tandem mass analysis. The results show a significant improvement in mass measurement accuracy on complex electron capture dissociation spectra of proteins. We also demonstrate how the improvement in mass accuracy can increase the confidence in protein identification from the fragment masses of proteins acquired in MS/MS experiments. © American Society for Mass Spectrometry 2004 |
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| container_issue |
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| title_short |
Improved mass accuracy for tandem mass spectrometry |
| url |
https://doi.org/10.1016/j.jasms.2004.12.005 |
| remote_bool |
false |
| author2 |
Anderson, Gordon A. Bruce, James E. |
| author2Str |
Anderson, Gordon A. Bruce, James E. |
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| doi_str |
10.1016/j.jasms.2004.12.005 |
| up_date |
2024-07-03T14:10:36.390Z |
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7.4005127 |