Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study
Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made...
Ausführliche Beschreibung
Autor*in: |
Dhaibar, Hemangini A. [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
3-Beta hydroxysteroid dehydrogenase (3-β HSD) |
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Anmerkung: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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Übergeordnetes Werk: |
Enthalten in: Environmental science and pollution research - Springer Berlin Heidelberg, 1994, 28(2020), 9 vom: 27. Okt., Seite 11077-11089 |
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Übergeordnetes Werk: |
volume:28 ; year:2020 ; number:9 ; day:27 ; month:10 ; pages:11077-11089 |
Links: |
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DOI / URN: |
10.1007/s11356-020-11278-x |
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Katalog-ID: |
OLC2123727288 |
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520 | |a Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. | ||
650 | 4 | |a Hexachlorobenzene (HCB) | |
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10.1007/s11356-020-11278-x doi (DE-627)OLC2123727288 (DE-He213)s11356-020-11278-x-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Dhaibar, Hemangini A. verfasserin aut Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study 2020 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity Patadia, Hemant aut Mansuri, Tabassum aut Shah, Ritu aut Khatri, Laxmichand aut Makwana, Hiral aut Master, Samip aut Robin, Pushpa (orcid)0000-0002-9071-9005 aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 28(2020), 9 vom: 27. Okt., Seite 11077-11089 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 https://doi.org/10.1007/s11356-020-11278-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 28 2020 9 27 10 11077-11089 |
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10.1007/s11356-020-11278-x doi (DE-627)OLC2123727288 (DE-He213)s11356-020-11278-x-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Dhaibar, Hemangini A. verfasserin aut Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study 2020 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity Patadia, Hemant aut Mansuri, Tabassum aut Shah, Ritu aut Khatri, Laxmichand aut Makwana, Hiral aut Master, Samip aut Robin, Pushpa (orcid)0000-0002-9071-9005 aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 28(2020), 9 vom: 27. Okt., Seite 11077-11089 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 https://doi.org/10.1007/s11356-020-11278-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 28 2020 9 27 10 11077-11089 |
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10.1007/s11356-020-11278-x doi (DE-627)OLC2123727288 (DE-He213)s11356-020-11278-x-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Dhaibar, Hemangini A. verfasserin aut Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study 2020 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity Patadia, Hemant aut Mansuri, Tabassum aut Shah, Ritu aut Khatri, Laxmichand aut Makwana, Hiral aut Master, Samip aut Robin, Pushpa (orcid)0000-0002-9071-9005 aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 28(2020), 9 vom: 27. Okt., Seite 11077-11089 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 https://doi.org/10.1007/s11356-020-11278-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 28 2020 9 27 10 11077-11089 |
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10.1007/s11356-020-11278-x doi (DE-627)OLC2123727288 (DE-He213)s11356-020-11278-x-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Dhaibar, Hemangini A. verfasserin aut Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study 2020 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity Patadia, Hemant aut Mansuri, Tabassum aut Shah, Ritu aut Khatri, Laxmichand aut Makwana, Hiral aut Master, Samip aut Robin, Pushpa (orcid)0000-0002-9071-9005 aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 28(2020), 9 vom: 27. Okt., Seite 11077-11089 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 https://doi.org/10.1007/s11356-020-11278-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 28 2020 9 27 10 11077-11089 |
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10.1007/s11356-020-11278-x doi (DE-627)OLC2123727288 (DE-He213)s11356-020-11278-x-p DE-627 ger DE-627 rakwb eng 570 360 333.7 VZ 690 333.7 540 VZ BIODIV DE-30 fid Dhaibar, Hemangini A. verfasserin aut Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study 2020 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2020 Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity Patadia, Hemant aut Mansuri, Tabassum aut Shah, Ritu aut Khatri, Laxmichand aut Makwana, Hiral aut Master, Samip aut Robin, Pushpa (orcid)0000-0002-9071-9005 aut Enthalten in Environmental science and pollution research Springer Berlin Heidelberg, 1994 28(2020), 9 vom: 27. Okt., Seite 11077-11089 (DE-627)171335805 (DE-600)1178791-0 (DE-576)038875101 0944-1344 nnns volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 https://doi.org/10.1007/s11356-020-11278-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_252 GBV_ILN_267 GBV_ILN_2018 GBV_ILN_4277 AR 28 2020 9 27 10 11077-11089 |
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Enthalten in Environmental science and pollution research 28(2020), 9 vom: 27. Okt., Seite 11077-11089 volume:28 year:2020 number:9 day:27 month:10 pages:11077-11089 |
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Hexachlorobenzene (HCB) Thyroid Hypothyroidism 3-Beta hydroxysteroid dehydrogenase (3-β HSD) 17-Beta hydroxysteroid dehydrogenase (17-β HSD) Estrous cyclicity |
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hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study |
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Hexachlorobenzene, a pollutant in hypothyroidism and reproductive aberrations: a perceptive transgenerational study |
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Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
abstract_unstemmed |
Abstract Hexachlorobenzene (HCB), a widespread environmental pollutant, contributes to endocrine disruption resulting in hypothyroidism. We investigated the effect of chronic exposure of HCB to explore the functional interconnection between hypothyroidism and infertility. All observations were made through the F1 and F2 generations. Thyroidectomy was also performed to evaluate the contribution of the thyroid gland in affecting ovarian dysfunction and reproductive aberrations. We confirmed that the preconception exposure of HCB leads to hypothyroidism which was reflected by an increase in the body weight, alteration in the thyroid hormones, and alteration of the lipid profile. Hypothyroid female rats exhibited a poor reproductive profile with altered steroidogenic pathways, altered estrus cyclicity, reduced litter size, and stunted growth. The external supplementation of thyroxine in thyroidectomized animals rescues the reproductive aberrations confirming the protective role of the thyroid gland in reproductive biology. All results highlight the jeopardizing functional connection of the thyroid and ovary due to HCB, leading to serious consequences on upcoming generations. © Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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