Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice
Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the c...
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Artikel |
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Englisch |
| Erschienen: |
2021 |
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© The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Environment, development and sustainability - Springer Netherlands, 1999, 23(2021), 10 vom: 24. Feb., Seite 14958-14981 |
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| Übergeordnetes Werk: |
volume:23 ; year:2021 ; number:10 ; day:24 ; month:02 ; pages:14958-14981 |
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| DOI / URN: |
10.1007/s10668-021-01281-8 |
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| 520 | |a Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation. | ||
| 650 | 4 | |a Essential oil | |
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| 700 | 1 | |a de Lima Silva, Maria Gabriely |4 aut | |
| 700 | 1 | |a Alcântara, Isabel Sousa |4 aut | |
| 700 | 1 | |a Filho, Jaime Ribeiro |4 aut | |
| 700 | 1 | |a Tintino, Cícera Datiane de Morais Oliveira |4 aut | |
| 700 | 1 | |a Magalhães, Francisco Ernani Alves |4 aut | |
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| 700 | 1 | |a de Lima, Sidney Gonçalo |4 aut | |
| 700 | 1 | |a Coutinho, Henrique Douglas Melo |4 aut | |
| 700 | 1 | |a Capasso, Raffaele |4 aut | |
| 700 | 1 | |a de Menezes, Irwin Rose Alencar |4 aut | |
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10.1007/s10668-021-01281-8 doi (DE-627)OLC2127367944 (DE-He213)s10668-021-01281-8-p DE-627 ger DE-627 rakwb eng 333.7 VZ 74.60$jRaumordnung$jStädtebau: Allgemeines bkl 74.60$jRaumordnung$jStädtebau: Allgemeines bkl 83.46$jEntwicklungsökonomie bkl de Oliveira, Maria Rayane Correia verfasserin aut Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice 2021 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation. Essential oil Anti-inflammatory activity Antinociceptive activity de Lima Silva, Maria Gabriely aut Alcântara, Isabel Sousa aut Filho, Jaime Ribeiro aut Tintino, Cícera Datiane de Morais Oliveira aut Magalhães, Francisco Ernani Alves aut Martins, Anita Oliveira Brito Pereira Bezerra aut Pessoa, Renata Torres aut Duarte, Antonia Eliene aut da Costa, José Galberto Martins aut de Lima, Sidney Gonçalo aut Coutinho, Henrique Douglas Melo aut Capasso, Raffaele aut de Menezes, Irwin Rose Alencar aut Enthalten in Environment, development and sustainability Springer Netherlands, 1999 23(2021), 10 vom: 24. Feb., Seite 14958-14981 (DE-627)247370592 (DE-600)1438730-X (DE-576)27365103X 1387-585X nnns volume:23 year:2021 number:10 day:24 month:02 pages:14958-14981 https://doi.org/10.1007/s10668-021-01281-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-GGO SSG-OLC-WIW SSG-OLC-FOR 74.60$jRaumordnung$jStädtebau: Allgemeines VZ 106413708 (DE-625)106413708 74.60$jRaumordnung$jStädtebau: Allgemeines VZ 106413708 (DE-625)106413708 83.46$jEntwicklungsökonomie VZ 106414925 (DE-625)106414925 AR 23 2021 10 24 02 14958-14981 |
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Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice |
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Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation. © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 |
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Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation. © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 |
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Abstract This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation. © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 |
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The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. 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