Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A

Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino...
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Gespeichert in:

Autor*in:	Bacher, A. [verfasserIn] Gilch, B. Rappold, H. Lingens, F.

Format:	Artikel

Erschienen:	1973

Anmerkung:	© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

Übergeordnetes Werk:	Enthalten in: Zeitschrift für Naturforschung. C, Biosciences - Verlag der Zeitschrift für Naturforschung, 1973, 28(1973), 9-10 vom: 01. Okt., Seite 614-617
Übergeordnetes Werk:	volume:28 ; year:1973 ; number:9-10 ; day:01 ; month:10 ; pages:614-617

Links:	Volltext

DOI / URN:	10.1515/znc-1973-9-1022

Katalog-ID:	OLC2139474686

Internformat


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024	7		\|a 10.1515/znc-1973-9-1022 \|2 doi
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100	1		\|a Bacher, A. \|e verfasserin \|4 aut
245	1	0	\|a Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
264		1	\|c 1973
336			\|a Text \|b txt \|2 rdacontent
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500			\|a © 1946 – 2014: Verlag der Zeitschrift für Naturforschung
520			\|a Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis.
700	1		\|a Gilch, B. \|4 aut
700	1		\|a Rappold, H. \|4 aut
700	1		\|a Lingens, F. \|4 aut
773	0	8	\|i Enthalten in \|t Zeitschrift für Naturforschung. C, Biosciences \|d Verlag der Zeitschrift für Naturforschung, 1973 \|g 28(1973), 9-10 vom: 01. Okt., Seite 614-617 \|w (DE-627)129307394 \|w (DE-600)124636-7 \|w (DE-576)014504936 \|x 0939-5075 \|7 nnns
773	1	8	\|g volume:28 \|g year:1973 \|g number:9-10 \|g day:01 \|g month:10 \|g pages:614-617
856	4	1	\|u https://doi.org/10.1515/znc-1973-9-1022 \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_OLC
912			\|a FID-BIODIV
912			\|a SSG-OLC-PHY
912			\|a SSG-OLC-CHE
912			\|a SSG-OLC-FOR
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_21
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_30
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_55
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_74
912			\|a GBV_ILN_105
912			\|a GBV_ILN_120
912			\|a GBV_ILN_121
912			\|a GBV_ILN_130
912			\|a GBV_ILN_154
912			\|a GBV_ILN_252
912			\|a GBV_ILN_254
912			\|a GBV_ILN_259
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2018
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2185
912			\|a GBV_ILN_2221
912			\|a GBV_ILN_2237
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4027
912			\|a GBV_ILN_4028
912			\|a GBV_ILN_4029
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4082
912			\|a GBV_ILN_4103
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4116
912			\|a GBV_ILN_4155
912			\|a GBV_ILN_4219
912			\|a GBV_ILN_4266
912			\|a GBV_ILN_4277
912			\|a GBV_ILN_4302
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4310
912			\|a GBV_ILN_4314
912			\|a GBV_ILN_4315
912			\|a GBV_ILN_4316
912			\|a GBV_ILN_4317
912			\|a GBV_ILN_4319
912			\|a GBV_ILN_4321
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 28 \|j 1973 \|e 9-10 \|b 01 \|c 10 \|h 614-617

Indexfelder

author_variant	a b ab b g bg h r hr f l fl
matchkey_str	article:09395075:1973----::nmardeooyteio4mnbnotiauatfeoatreoeerqiigaioez
hierarchy_sort_str	1973
publishDate	1973
allfields	10.1515/znc-1973-9-1022 doi (DE-627)OLC2139474686 (DE-B1597)znc-1973-9-1022-p DE-627 ger DE-627 rakwb 500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Bacher, A. verfasserin aut Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A 1973 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © 1946 – 2014: Verlag der Zeitschrift für Naturforschung Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. Gilch, B. aut Rappold, H. aut Lingens, F. aut Enthalten in Zeitschrift für Naturforschung. C, Biosciences Verlag der Zeitschrift für Naturforschung, 1973 28(1973), 9-10 vom: 01. Okt., Seite 614-617 (DE-627)129307394 (DE-600)124636-7 (DE-576)014504936 0939-5075 nnns volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617 https://doi.org/10.1515/znc-1973-9-1022 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_254 GBV_ILN_259 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2185 GBV_ILN_2221 GBV_ILN_2237 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4155 GBV_ILN_4219 GBV_ILN_4266 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4316 GBV_ILN_4317 GBV_ILN_4319 GBV_ILN_4321 GBV_ILN_4323 GBV_ILN_4700 AR 28 1973 9-10 01 10 614-617
spelling	10.1515/znc-1973-9-1022 doi (DE-627)OLC2139474686 (DE-B1597)znc-1973-9-1022-p DE-627 ger DE-627 rakwb 500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Bacher, A. verfasserin aut Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A 1973 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © 1946 – 2014: Verlag der Zeitschrift für Naturforschung Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. Gilch, B. aut Rappold, H. aut Lingens, F. aut Enthalten in Zeitschrift für Naturforschung. C, Biosciences Verlag der Zeitschrift für Naturforschung, 1973 28(1973), 9-10 vom: 01. Okt., Seite 614-617 (DE-627)129307394 (DE-600)124636-7 (DE-576)014504936 0939-5075 nnns volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617 https://doi.org/10.1515/znc-1973-9-1022 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_254 GBV_ILN_259 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2185 GBV_ILN_2221 GBV_ILN_2237 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4155 GBV_ILN_4219 GBV_ILN_4266 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4316 GBV_ILN_4317 GBV_ILN_4319 GBV_ILN_4321 GBV_ILN_4323 GBV_ILN_4700 AR 28 1973 9-10 01 10 614-617
allfields_unstemmed	10.1515/znc-1973-9-1022 doi (DE-627)OLC2139474686 (DE-B1597)znc-1973-9-1022-p DE-627 ger DE-627 rakwb 500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Bacher, A. verfasserin aut Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A 1973 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © 1946 – 2014: Verlag der Zeitschrift für Naturforschung Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. Gilch, B. aut Rappold, H. aut Lingens, F. aut Enthalten in Zeitschrift für Naturforschung. C, Biosciences Verlag der Zeitschrift für Naturforschung, 1973 28(1973), 9-10 vom: 01. Okt., Seite 614-617 (DE-627)129307394 (DE-600)124636-7 (DE-576)014504936 0939-5075 nnns volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617 https://doi.org/10.1515/znc-1973-9-1022 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_254 GBV_ILN_259 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2185 GBV_ILN_2221 GBV_ILN_2237 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4155 GBV_ILN_4219 GBV_ILN_4266 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4316 GBV_ILN_4317 GBV_ILN_4319 GBV_ILN_4321 GBV_ILN_4323 GBV_ILN_4700 AR 28 1973 9-10 01 10 614-617
allfieldsGer	10.1515/znc-1973-9-1022 doi (DE-627)OLC2139474686 (DE-B1597)znc-1973-9-1022-p DE-627 ger DE-627 rakwb 500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Bacher, A. verfasserin aut Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A 1973 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © 1946 – 2014: Verlag der Zeitschrift für Naturforschung Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. Gilch, B. aut Rappold, H. aut Lingens, F. aut Enthalten in Zeitschrift für Naturforschung. C, Biosciences Verlag der Zeitschrift für Naturforschung, 1973 28(1973), 9-10 vom: 01. Okt., Seite 614-617 (DE-627)129307394 (DE-600)124636-7 (DE-576)014504936 0939-5075 nnns volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617 https://doi.org/10.1515/znc-1973-9-1022 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_254 GBV_ILN_259 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2185 GBV_ILN_2221 GBV_ILN_2237 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4155 GBV_ILN_4219 GBV_ILN_4266 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4316 GBV_ILN_4317 GBV_ILN_4319 GBV_ILN_4321 GBV_ILN_4323 GBV_ILN_4700 AR 28 1973 9-10 01 10 614-617
allfieldsSound	10.1515/znc-1973-9-1022 doi (DE-627)OLC2139474686 (DE-B1597)znc-1973-9-1022-p DE-627 ger DE-627 rakwb 500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Bacher, A. verfasserin aut Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A 1973 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © 1946 – 2014: Verlag der Zeitschrift für Naturforschung Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. Gilch, B. aut Rappold, H. aut Lingens, F. aut Enthalten in Zeitschrift für Naturforschung. C, Biosciences Verlag der Zeitschrift für Naturforschung, 1973 28(1973), 9-10 vom: 01. Okt., Seite 614-617 (DE-627)129307394 (DE-600)124636-7 (DE-576)014504936 0939-5075 nnns volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617 https://doi.org/10.1515/znc-1973-9-1022 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_105 GBV_ILN_120 GBV_ILN_121 GBV_ILN_130 GBV_ILN_154 GBV_ILN_252 GBV_ILN_254 GBV_ILN_259 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2185 GBV_ILN_2221 GBV_ILN_2237 GBV_ILN_4012 GBV_ILN_4027 GBV_ILN_4028 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4082 GBV_ILN_4103 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4155 GBV_ILN_4219 GBV_ILN_4266 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4316 GBV_ILN_4317 GBV_ILN_4319 GBV_ILN_4321 GBV_ILN_4323 GBV_ILN_4700 AR 28 1973 9-10 01 10 614-617
source	Enthalten in Zeitschrift für Naturforschung. C, Biosciences 28(1973), 9-10 vom: 01. Okt., Seite 614-617 volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617
sourceStr	Enthalten in Zeitschrift für Naturforschung. C, Biosciences 28(1973), 9-10 vom: 01. Okt., Seite 614-617 volume:28 year:1973 number:9-10 day:01 month:10 pages:614-617
format_phy_str_mv	Article
institution	findex.gbv.de
dewey-raw	500
isfreeaccess_bool	false
container_title	Zeitschrift für Naturforschung. C, Biosciences
authorswithroles_txt_mv	Bacher, A. @@aut@@ Gilch, B. @@aut@@ Rappold, H. @@aut@@ Lingens, F. @@aut@@
publishDateDaySort_date	1973-10-01T00:00:00Z
hierarchy_top_id	129307394
dewey-sort	3500
id	OLC2139474686
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author	Bacher, A.
spellingShingle	Bacher, A. ddc 500 ddc 570 ssgn 12 fid BIODIV Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
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topic_title	500 VZ 570 VZ 12 ssgn BIODIV DE-30 fid Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
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title	Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
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title_full	Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
author_sort	Bacher, A.
journal	Zeitschrift für Naturforschung. C, Biosciences
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author_browse	Bacher, A. Gilch, B. Rappold, H. Lingens, F.
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title_sort	unimpaired de novo synthesis of 4-aminobenzoate in a mutant of aerobacter aerogenes requiring 4-aminobenzoate for growth; structure of compound a
title_auth	Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
abstract	Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. © 1946 – 2014: Verlag der Zeitschrift für Naturforschung
abstractGer	Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. © 1946 – 2014: Verlag der Zeitschrift für Naturforschung
abstract_unstemmed	Abstract The mutant strain Aerobacter aerogenes 62-1 AC, $ pab^{-} $, accumulates a labile substance, designated Compound A which supports the growth of other $ pab^{- } $mutants. Previous studies seemed to indicate that Compound A might be an intermediate in the conversion of chorismate to 4-amino-benzoate (Altendorf, Bacher, and Lingens, Z. Naturforsch. 24 b, 1602 [1969]). The present experi ments show that Compound A is 4 -(D-glucosylamino)-benzoic acid. This substance which is clearly not an intermediate in the biosynthesis of 4-aminobenzoate is formed by reaction of 4-aminobenzoate produced de novo by the mutant with exogenous glucose. Mutant 62-1 AC has the unimpaired capacity to synthesize 4-aminobenzoate as shown by direct enzyme studies. Mutant 62-1 AC re quires approximately 200 times more 4jaminobenzoate for growth than other pab" mutants of A. aerogenes with defective 4-aminobenzoate synthetase. The genetic defect of mutant 62-1 AC seems to be located in a metabolic system concerned with the utilization of 4-aminobenzoate rather than its synthesis. © 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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title_short	Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A
url	https://doi.org/10.1515/znc-1973-9-1022
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up_date	2024-07-03T20:12:38.281Z
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Unimpaired de novo Synthesis of 4-Aminobenzoate in a Mutant of Aerobacter aerogenes Requiring 4-Aminobenzoate for Growth; Structure of Compound A

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