Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel
Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed...
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| Autor*in: |
Nagarajaiah, Shobha [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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© The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Enthalten in: Applied physics. A, Materials science & processing - Springer Berlin Heidelberg, 1981, 129(2023), 6 vom: Juni |
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| Übergeordnetes Werk: |
volume:129 ; year:2023 ; number:6 ; month:06 |
| Links: |
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| DOI / URN: |
10.1007/s00339-023-06731-w |
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| 520 | |a Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. | ||
| 650 | 4 | |a ZnO nanoparticles | |
| 650 | 4 | |a Solution combustion | |
| 650 | 4 | |a Anticancer activity | |
| 650 | 4 | |a Antioxidant | |
| 650 | 4 | |a Clonogenic assay | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Biocompatibility | |
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| 700 | 1 | |a Manjappa, Praveen |4 aut | |
| 700 | 1 | |a Nagabhushana, Bhangi Mutta |4 aut | |
| 700 | 1 | |a Gadewar, Manoj |4 aut | |
| 700 | 1 | |a Rao, Srilatha |4 aut | |
| 700 | 1 | |a Krishna, Prashanth Gopala |0 (orcid)0000-0001-6691-4030 |4 aut | |
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10.1007/s00339-023-06731-w doi (DE-627)OLC2143654413 (DE-He213)s00339-023-06731-w-p DE-627 ger DE-627 rakwb eng 530 620 VZ 530 VZ Nagarajaiah, Shobha verfasserin aut Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. ZnO nanoparticles Solution combustion Anticancer activity Antioxidant Clonogenic assay Apoptosis Biocompatibility Nanda, N. aut Manjappa, Praveen aut Nagabhushana, Bhangi Mutta aut Gadewar, Manoj aut Rao, Srilatha aut Krishna, Prashanth Gopala (orcid)0000-0001-6691-4030 aut Enthalten in Applied physics. A, Materials science & processing Springer Berlin Heidelberg, 1981 129(2023), 6 vom: Juni (DE-627)129861340 (DE-600)283365-7 (DE-576)015171930 0947-8396 nnns volume:129 year:2023 number:6 month:06 https://doi.org/10.1007/s00339-023-06731-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_2018 GBV_ILN_4277 AR 129 2023 6 06 |
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10.1007/s00339-023-06731-w doi (DE-627)OLC2143654413 (DE-He213)s00339-023-06731-w-p DE-627 ger DE-627 rakwb eng 530 620 VZ 530 VZ Nagarajaiah, Shobha verfasserin aut Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. ZnO nanoparticles Solution combustion Anticancer activity Antioxidant Clonogenic assay Apoptosis Biocompatibility Nanda, N. aut Manjappa, Praveen aut Nagabhushana, Bhangi Mutta aut Gadewar, Manoj aut Rao, Srilatha aut Krishna, Prashanth Gopala (orcid)0000-0001-6691-4030 aut Enthalten in Applied physics. A, Materials science & processing Springer Berlin Heidelberg, 1981 129(2023), 6 vom: Juni (DE-627)129861340 (DE-600)283365-7 (DE-576)015171930 0947-8396 nnns volume:129 year:2023 number:6 month:06 https://doi.org/10.1007/s00339-023-06731-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_2018 GBV_ILN_4277 AR 129 2023 6 06 |
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10.1007/s00339-023-06731-w doi (DE-627)OLC2143654413 (DE-He213)s00339-023-06731-w-p DE-627 ger DE-627 rakwb eng 530 620 VZ 530 VZ Nagarajaiah, Shobha verfasserin aut Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. ZnO nanoparticles Solution combustion Anticancer activity Antioxidant Clonogenic assay Apoptosis Biocompatibility Nanda, N. aut Manjappa, Praveen aut Nagabhushana, Bhangi Mutta aut Gadewar, Manoj aut Rao, Srilatha aut Krishna, Prashanth Gopala (orcid)0000-0001-6691-4030 aut Enthalten in Applied physics. A, Materials science & processing Springer Berlin Heidelberg, 1981 129(2023), 6 vom: Juni (DE-627)129861340 (DE-600)283365-7 (DE-576)015171930 0947-8396 nnns volume:129 year:2023 number:6 month:06 https://doi.org/10.1007/s00339-023-06731-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_2018 GBV_ILN_4277 AR 129 2023 6 06 |
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10.1007/s00339-023-06731-w doi (DE-627)OLC2143654413 (DE-He213)s00339-023-06731-w-p DE-627 ger DE-627 rakwb eng 530 620 VZ 530 VZ Nagarajaiah, Shobha verfasserin aut Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. ZnO nanoparticles Solution combustion Anticancer activity Antioxidant Clonogenic assay Apoptosis Biocompatibility Nanda, N. aut Manjappa, Praveen aut Nagabhushana, Bhangi Mutta aut Gadewar, Manoj aut Rao, Srilatha aut Krishna, Prashanth Gopala (orcid)0000-0001-6691-4030 aut Enthalten in Applied physics. A, Materials science & processing Springer Berlin Heidelberg, 1981 129(2023), 6 vom: Juni (DE-627)129861340 (DE-600)283365-7 (DE-576)015171930 0947-8396 nnns volume:129 year:2023 number:6 month:06 https://doi.org/10.1007/s00339-023-06731-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_2018 GBV_ILN_4277 AR 129 2023 6 06 |
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10.1007/s00339-023-06731-w doi (DE-627)OLC2143654413 (DE-He213)s00339-023-06731-w-p DE-627 ger DE-627 rakwb eng 530 620 VZ 530 VZ Nagarajaiah, Shobha verfasserin aut Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. ZnO nanoparticles Solution combustion Anticancer activity Antioxidant Clonogenic assay Apoptosis Biocompatibility Nanda, N. aut Manjappa, Praveen aut Nagabhushana, Bhangi Mutta aut Gadewar, Manoj aut Rao, Srilatha aut Krishna, Prashanth Gopala (orcid)0000-0001-6691-4030 aut Enthalten in Applied physics. A, Materials science & processing Springer Berlin Heidelberg, 1981 129(2023), 6 vom: Juni (DE-627)129861340 (DE-600)283365-7 (DE-576)015171930 0947-8396 nnns volume:129 year:2023 number:6 month:06 https://doi.org/10.1007/s00339-023-06731-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-PHY GBV_ILN_2018 GBV_ILN_4277 AR 129 2023 6 06 |
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Evaluation of apoptosis in human breast cancer cell (MDA-MB-231) induced by ZnO nanoparticles synthesized using Piper betle leaf extract as bio-fuel |
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Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Abstract In this investigation, zinc oxide nanoparticles (ZnO NPs) were produced by solution combustion-assisted technique utilising aqueous leaf extract of Piper betle (betel leaf) (PB). Phase formation and the particle size of ZnO-PB-NPs were ascertained by using X-ray diffraction. It was observed that the ZnO-PB-NPs crystallize in the hexagonal phase with an average crystallite size of 24 nm. The morphology, shape, and size of the NPs were studied by Scanning Electron Microscope and Transmission Electron Microscope (TEM). The elemental composition was analysed using energy-dispersive advanced X-ray spectroscopy. Further, Fourier-Transform Infrared (FTIR) spectroscopy confirmed the formation of ZnO bonding. Anticancer activity of ZnO-PB-NPs was evaluated in the MDA-MB-231, human breast cancer cells by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assay. The study findings demonstrated that the ZnO-PB-NPs were able to induce significant cytotoxicity in human breast cancer cells in a dose-dependent manner. ZnO-PB-NPs treatment impaired the Clonogenic potential cells of breast cancer. Additionally, the biocompatibility with blood components of ZnO-PB-NPs was evaluated by blood hemolysis assay. It was observed that, ZnO NPs inhibited breast cancer cell growth and increased the induction of early apoptosis cell population. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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