Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubi...
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Gespeichert in:
| Autor*in: |
Ol’khovich, Marina [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Korean Institute of Chemical Engineers 2023 |
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| Übergeordnetes Werk: |
Enthalten in: The Korean journal of chemical engineering - Springer US, 1984, 40(2023), 6 vom: 17. Mai, Seite 1474-1485 |
|---|---|
| Übergeordnetes Werk: |
volume:40 ; year:2023 ; number:6 ; day:17 ; month:05 ; pages:1474-1485 |
| Links: |
|---|
| DOI / URN: |
10.1007/s11814-023-1429-8 |
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OLC214386860X |
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| 520 | |a Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. | ||
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| 700 | 1 | |a Sharapova, Angelica |4 aut | |
| 700 | 1 | |a Blokhina, Svetlana |4 aut | |
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10.1007/s11814-023-1429-8 doi (DE-627)OLC214386860X (DE-He213)s11814-023-1429-8-p DE-627 ger DE-627 rakwb eng 660 VZ 58.00 bkl Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin Solubility Solvation Activity Coefficients Partition Thermodynamics Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Springer US, 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)129165409 (DE-600)50398-8 (DE-576)099445263 0256-1115 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE 58.00 VZ AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)OLC214386860X (DE-He213)s11814-023-1429-8-p DE-627 ger DE-627 rakwb eng 660 VZ 58.00 bkl Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin Solubility Solvation Activity Coefficients Partition Thermodynamics Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Springer US, 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)129165409 (DE-600)50398-8 (DE-576)099445263 0256-1115 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE 58.00 VZ AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)OLC214386860X (DE-He213)s11814-023-1429-8-p DE-627 ger DE-627 rakwb eng 660 VZ 58.00 bkl Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin Solubility Solvation Activity Coefficients Partition Thermodynamics Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Springer US, 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)129165409 (DE-600)50398-8 (DE-576)099445263 0256-1115 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE 58.00 VZ AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)OLC214386860X (DE-He213)s11814-023-1429-8-p DE-627 ger DE-627 rakwb eng 660 VZ 58.00 bkl Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin Solubility Solvation Activity Coefficients Partition Thermodynamics Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Springer US, 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)129165409 (DE-600)50398-8 (DE-576)099445263 0256-1115 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE 58.00 VZ AR 40 2023 6 17 05 1474-1485 |
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10.1007/s11814-023-1429-8 doi (DE-627)OLC214386860X (DE-He213)s11814-023-1429-8-p DE-627 ger DE-627 rakwb eng 660 VZ 58.00 bkl Ol’khovich, Marina verfasserin aut Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes 2023 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier © The Korean Institute of Chemical Engineers 2023 Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. Griseofulvin Solubility Solvation Activity Coefficients Partition Thermodynamics Sharapova, Angelica aut Blokhina, Svetlana aut Enthalten in The Korean journal of chemical engineering Springer US, 1984 40(2023), 6 vom: 17. Mai, Seite 1474-1485 (DE-627)129165409 (DE-600)50398-8 (DE-576)099445263 0256-1115 nnns volume:40 year:2023 number:6 day:17 month:05 pages:1474-1485 https://doi.org/10.1007/s11814-023-1429-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE 58.00 VZ AR 40 2023 6 17 05 1474-1485 |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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Ol’khovich, Marina |
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The Korean journal of chemical engineering |
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The Korean journal of chemical engineering |
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2023 |
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1474 |
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Ol’khovich, Marina Sharapova, Angelica Blokhina, Svetlana |
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Ol’khovich, Marina |
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10.1007/s11814-023-1429-8 |
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660 |
| title_sort |
griseofulvin: thermodynamic insight to solubility, solvation and partition processes |
| title_auth |
Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
| abstract |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
| abstractGer |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
| abstract_unstemmed |
Abstract The solubility of griseofulvin in buffer solutions (pH 2.0 and 7.4), 1-octanol and hexane was measured in the temperature range 293.15–313.15 K by the shake flask method. It was found that griseofulvin is poorly soluble in aqueous buffer solutions (x≤8.63·$ 10^{−7} $), while the best solubility is observed in 1-octanol (x≤6.56·$ 10^{−4} $). The solubility evaluation in different solvents with the help of Hansen solubility parameters showed the consistency with the experimental data. The solubility was revealed to significantly depend on the dispersion interactions and polar bonds. The dissolution and solvation thermodynamic functions of the drug were calculated. The Gibbs energy and enthalpy of drug dissolution in aqueous and organic solvents are positive, which characterizes the dissolution process as hindered and endothermic. The van’t Hoff and Apelblat equations gave good correlations when used for modeling the experimental solubility results. Based on the data on the solubility and thermophysical parameters of the compound, the temperature dependences of the activity coefficients were determined and the excess thermodynamic functions of dissolution were calculated. Positive deviation from ideality was observed in all the solvent-solute systems studied. The partition coefficients of the drug in the 1-octanol/buffer pH 7.4 system were obtained and the transfer thermodynamic functions were derived. It was established that the drug distribution from the aqueous solution to the octanol phase was thermodynamically favorable and endothermic. © The Korean Institute of Chemical Engineers 2023 |
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Griseofulvin: Thermodynamic insight to solubility, solvation and partition processes |
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https://doi.org/10.1007/s11814-023-1429-8 |
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Sharapova, Angelica Blokhina, Svetlana |
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