Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse
Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Le Floc’h, Audrey [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Basel 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Cellular and molecular life sciences - Cham (ZG) : Springer International Publishing AG, 1997, 72(2014), 3 vom: 30. Okt., Seite 537-556 |
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| Übergeordnetes Werk: |
volume:72 ; year:2014 ; number:3 ; day:30 ; month:10 ; pages:537-556 |
| Links: |
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| DOI / URN: |
10.1007/s00018-014-1760-7 |
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| Katalog-ID: |
SPR000170224 |
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| 100 | 1 | |a Le Floc’h, Audrey |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
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| 520 | |a Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. | ||
| 650 | 4 | |a Cytoskeleton |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Actin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunological synapse |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Cytotoxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Signal transduction |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Huse, Morgan |4 aut | |
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2014 |
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10.1007/s00018-014-1760-7 doi (DE-627)SPR000170224 (SPR)s00018-014-1760-7-e DE-627 ger DE-627 rakwb eng Le Floc’h, Audrey verfasserin aut Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Basel 2014 Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. Cytoskeleton (dpeaa)DE-He213 Actin (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Immunological synapse (dpeaa)DE-He213 T cell receptor (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Huse, Morgan aut Enthalten in Cellular and molecular life sciences Cham (ZG) : Springer International Publishing AG, 1997 72(2014), 3 vom: 30. Okt., Seite 537-556 (DE-627)253390524 (DE-600)1458497-9 1420-9071 nnns volume:72 year:2014 number:3 day:30 month:10 pages:537-556 https://dx.doi.org/10.1007/s00018-014-1760-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 72 2014 3 30 10 537-556 |
| spelling |
10.1007/s00018-014-1760-7 doi (DE-627)SPR000170224 (SPR)s00018-014-1760-7-e DE-627 ger DE-627 rakwb eng Le Floc’h, Audrey verfasserin aut Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Basel 2014 Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. Cytoskeleton (dpeaa)DE-He213 Actin (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Immunological synapse (dpeaa)DE-He213 T cell receptor (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Huse, Morgan aut Enthalten in Cellular and molecular life sciences Cham (ZG) : Springer International Publishing AG, 1997 72(2014), 3 vom: 30. Okt., Seite 537-556 (DE-627)253390524 (DE-600)1458497-9 1420-9071 nnns volume:72 year:2014 number:3 day:30 month:10 pages:537-556 https://dx.doi.org/10.1007/s00018-014-1760-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 72 2014 3 30 10 537-556 |
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Enthalten in Cellular and molecular life sciences 72(2014), 3 vom: 30. Okt., Seite 537-556 volume:72 year:2014 number:3 day:30 month:10 pages:537-556 |
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Le Floc’h, Audrey @@aut@@ Huse, Morgan @@aut@@ |
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Le Floc’h, Audrey |
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Le Floc’h, Audrey misc Cytoskeleton misc Actin misc T cells misc Immunological synapse misc T cell receptor misc Cytotoxicity misc Signal transduction Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
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Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse Cytoskeleton (dpeaa)DE-He213 Actin (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Immunological synapse (dpeaa)DE-He213 T cell receptor (dpeaa)DE-He213 Cytotoxicity (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 |
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Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
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molecular mechanisms and functional implications of polarized actin remodeling at the t cell immunological synapse |
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Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
| abstract |
Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. © Springer Basel 2014 |
| abstractGer |
Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. © Springer Basel 2014 |
| abstract_unstemmed |
Abstract Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. © Springer Basel 2014 |
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Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
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https://dx.doi.org/10.1007/s00018-014-1760-7 |
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10.1007/s00018-014-1760-7 |
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2024-07-03T14:24:14.826Z |
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|
| score |
7.400319 |